CAS: 14328-63-3; H-Chg-Ome.Hcl

相似化合物

14328-64-4 210629-78-0 127042-68-6

上下游产品

CAS号15028-39-4 (S)-(+)-2-苯基甘氨酸甲酯 | CAS号848777-29-7 Cyclohexaneacet...

(S)-(+)-2-苯甘氨酸甲酯 盐酸盐置于盐酸,氢气体系中,用 甲醇,水 用作溶剂,20.0 °C,101.33 Kpa 条件下,反应 24.0H,以97%的收率获得l-环己基甘氨酸甲酯盐酸盐
参考文献:铑/石墨催化的碳环和杂环芳族化合物的加氢
标题:铑/石墨催化的碳环和杂环芳族化合物的加氢
摘要:石墨上的铑(rh / Gr,C 24 Rh)是通过无水三氯化铑与石墨钾(c 8 K,3当量)反应制得的,并用作在室温下氢化碳环和杂环芳族化合物的非均相催化剂.氢气压力为1大气压.在多种衍生物中检查了取代对苯环的影响,包括具有烷基,羟基,烷氧基,芳氧基,羧基,氨基,硝基,酰基,氯代或官能化烷基的那些衍生物.芳族醛和酮的羰基官能团还原发生在苄基co键完全或部分断裂的情况下;这种裂解也发生在苄醇和酯的氢化中. 芳香族化合物-石墨-非均相催化-加氢-铑
Doi:10.1055/s-0029-1216852

专利信息

专利号:US-8591878-B2
优先权日:2008-02-25
标 题:Therapeutic compounds
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; HARPER STEVEN; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME; ANGELETTI P IST RICHERCHE BIO
摘要:A class of macrocyclic compounds of formula (I), wherein R 1 , R 3 , R 4 , R a , R b , A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

专利号:US-8309540-B2
优先权日:2006-10-24
标 题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; VACCA JOSEPH P; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T
权利人:LIVERTON NIGEL J; VACCA JOSEPH P; MCCAULEY JOHN A; ROMANO JOSEPH J; RUDD MICHAEL T; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. (I)