CAS: 133053-19-7; 3-(1-(3-(Dimethylamino)Propyl)-5-Methoxy-1H-Indol-3-yl)-4-(1H-Indol-3-yl)-1H-Pyrrole-2,5-Dione

该化合物是复杂的有机化合物,其特点是多环结构,包括不露和火花糖.该化合物具有二甲基氨基化合物的特征,有助于其潜在的生物活动,特别是在药理学方面.甲基氨基化合物的存在表明,它可能表现出亲脂性,影响其溶性与生物系统中的渗透性和渗透性.功能组的复杂安排表明它可能与各种生物目标发生相互作用,使其对药用化学感兴趣.此外,其结构复杂性可能导致独特的电子特性,这与新型治疗剂的开发有关.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

3-(1H-indol-3-yl)-4-5-methoxy-1-[3-(methanesulfonyloxy)propyl]-1H-indol-3-ylpyrrol-2,5-dione dimethyl amine 3-indolylacetamide 3-[1-(3-hydroxypropyl)-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)pyrroI-2,5-dione

合成工艺路线路线简述

    📜3-吲哚乙酰胺置于potassium Tert-Butylate,三乙胺体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 32.39H,反应生成3-[1-[3-(二甲基氨基)丙基]-5-甲氧基-1H-吲哚-3-基]-4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮
    参考文献:Wo2008/117935
    标题:Wo2008/117935

    海关参考信息

    专利信息


    专利号:US-2005192265-A1
    优先权日:2003-03-20
    标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
    发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-6906056-B2
    优先权日:1998-06-22
    标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
    权利人:LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-2004106598-A1
    优先权日:1998-06-22
    标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting Beta-amyloid peptide release and/or its synthesis by use of such compounds

    专利号:US-2005192269-A1
    优先权日:1998-06-22
    标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

    专利号:US-6569851-B1
    优先权日:1998-06-22
    标 题 :Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

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    主要参考文献


    1: Dai B, Zhang J, Liu M, Lu J, Zhang Y, Xu Y, Miao J, Yin Y. The role of Ca(2+) mediated signaling pathways on the effect of taurine against Streptococcus uberis infection. Vet Microbiol. 2016 Aug 30;192:26-33. doi: 10.1016/j.vetmic.2016.06.008. doi: 10.1111/bph.13570. Chinese. doi: 10.1007/s00726-015-2154-3. doi: 10.1016/j.bbrc.2015.09.028. doi: 10.1016/j.yjmcc.2015.07.014.
    7: Wei X, Zhang B, Cheng L, Chi M, Deng L, Pan H, Yao X, Wang G. Hydrogen sulfide induces neuroprotection against experimental stroke in rats by down-regulation of AQP4 via activating PKC. Brain Res. 2015 Oct 5;1622:292-9. doi: 10.1016/j.brainres.2015.07.001. pii: ftv045. doi: 10.1093/femspd/ftv045.
    9: Xu H, Czerwinski P, Xia N, Förstermann U, Li H. Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells. Pharmacology. 2015;96(1-2):1-10. doi: 10.1159/000430823. Chinese. doi: 10.1371/journal.pone.0122179.

    合成参考文献


    参考文献:10.3858/emm.2011.43.9.060
    摘要:Cho SC, Rhim JH, Choi HR, Son YH, Lee SJ, Song K, Park SC. Protective effect of 4,4'-diaminodiphenylsulfone against paraquat-induced mouse lung injury. Experimental & Molecular Medicine. 2011 Jul 18;43(9):525–37. doi: 10.3858/emm.2011.43.9.060.
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