CAS: 1316214-52-4; 2-(Diphenylamino)-N-(7-(Hydroxyamino)-7-Oxoheptyl)Pyrimidine-5-Carboxamide

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CAS号1316216-07-5 7-({2-[(1-Methy... | CAS号89793-12-4 2-氯嘧啶-5-羧酸乙酯 | CAS号864172-93-0 5-Pyrimidinecar... | CAS号95928-49-7 2-羟基嘧啶-5-羧酸乙酯 | CAS号1316216-05-3 2-(二苯基氨基)嘧啶-5-羧酸乙酯 | CAS号1316216-06-4 2-(diphenylamin...

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-11666569-B2
优先权日:2013-10-24
标题 :Treatment of polycystic diseases with an HDAC6 inhibitor
发明人：GRADILONE SERGIO A; LARUSSO NICHOLAS F
权利人:MAYO FOUND MEDICAL EDUCATION & RES; NAT INSTITUTES OF HEALTH NIH U S DEPT OF HEALTH AND HUMAN SERVICES DHHS U S GOVERNMENT
摘要:An HDAC6-specific inhibitor (i.e., a compound of Formula I or II) is shown to reduce the pathogenesis associated with polycystic disease. Administration of an HDAC6-specific inhibitor attenuated many of the symptoms characteristic of polycystic liver disease including cyst formation, cyst growth and cholangiocyte proliferation. Treatment with a HDAC6-specific inhibitor also increased the amount of bile duct acetylated tubulin and β-catenin phosphorylation and/or acetylation while reducing bile duct β-catenin synthesis. These results demonstrate that HDAC6 is overexpressed in cystic cholangiocytes and that its pharmacological inhibition reduces cholangiocyte proliferation and cyst growth.

专利号:US-10144714-B2
优先权日:2015-06-08
标 题 :Methods of making protein deacetylase inhibitors
发明人：SEYEDI FARZANEH; VAN DUZER JOHN H
权利人:ACETYLON PHARMACEUTICALS INC
摘要:The present invention relates to methods and intermediates useful for the synthesis of protein deacetylase inhibitors.

专利号:US-11059815-B2
优先权日:2018-07-23
标 题:Synthesis of small molecule histone deacetylase 6 degraders, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; Yang Ka; WU HAO; ZHANG ZHONGRUI
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Histone deacetylase (“HDACâ€?)-selective inhibitors covalently bonded to a linker covalently bonded to an E3 ubiquitin ligase ligand, and salts thereof; pharmaceutical compositions containing them; methods of using the composition to inhibit neoplastic cell growth in mammals, including humans.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.