CAS: 118452-02-1; 2-Aminothiazole-4-Carboxamide

相似化合物

98027-21-5 89363-94-0 827588-55-6

上下游产品

CAS号5398-36-7 2-氨基噻唑-4-甲酸乙酯 | CAS号118452-04-3 2-氨基噻唑-4-甲酸甲酯

📜2-氨基噻唑-4-甲酸甲酯置于氨体系中,化学反应 12.0H,以47%的收率获得2-氨基-噻唑-4-甲酰胺
参考文献:Sanghvi,Yogesh S.; Larson,Steven B.; Robins,Roland K.,Journal Of Heterocyclic Chemistry,1988,Vol. 25,P. 623-633
标题:Sanghvi,Yogesh S.; Larson,Steven B.; Robins,Roland K.,Journal Of Heterocyclic Chemistry,1988,Vol. 25,P. 623-633

专利信息

专利号:WO-2014016766-A1
优先权日:2012-07-25
标 题:Guanidine derivatives as trpc modulators
发明人：LINGAM V S PRASADA RAO; THOMAS ABRAHAM; DAHALE DNYANESHWAR HARISHCHANDRA; RATHI VIJAY EKNATH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:GLENMARK PHARMACEUTICALS SA
摘要:The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I)).