CAS: 109434-24-4; Fmoc-His(Trt)-Opfp
该化合物是氨酸丁酯的一种受保护衍生物,常用于丙酸合成和研究中.Fmoc(9-氟基甲基乙基碳基)组是氨基功能的保护组,允许有选择地作出反应,而不会干扰侧链.三丁基组为异丁胺的蛋白侧链提供了额外的保护,加强了合成过程中的稳定性.五氟苯酯系是一个反应组,有助于将该化合物与其他氨基酸或丙胺结合,使其在固相合成中具有价值.该化合物的特点是在标准条件下相对较高的稳定性,但在特定条件下可以放松保护,以产生活性丁胺残留物.该化合物的独特结构允许将异丁酯引入peptide,同时保持对生物活动和功能至关重要的侧链的完整性.该化合物在生物化学合成领域具有重要的意义.该复合化学合成领域.
- 英文名称Fmoc-His(Trt)-Opfp
- 中文名称N-Fmoc-N'-三苯甲基-L-组氨酸五氟苯基酯
- IUPAC名称perfluorophenyl Na-(((9H-fluoren-9-yl)methoxy)carbonyl)-Nt-trityl-L-histidinate
- 其它别名Fmoc-His(Trt)-Opfp; Fmoc-His(1-Trt)-Opfp; (2,3,4,5,6-Pentafluorophenyl) (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-3-(1-Tritylimidazol-4-yl)Propanoate; N; A-Fmoc-N(Im)-Trityl-L-Histidine Pentafluorophenyl Ester; (S)-Perfluorophenyl 2-((((9H-Fluor
- CAS编号109434-24-4
- MFCD编号:MFCD00065653
- 分子式:C46H32F5N3O4分子量:785.77
- 产品CID: 131478
- 产品分类有机原料→生命科学→氨基酸及其衍生物→组氨酸及其衍生物
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133367-33-6 109425-51-6 135610-90-1物理性质
MSDS等安全信息
合成工艺路线路线简述
专利信息
专利号:US-5262331-A
优先权日:1989-08-28
标 题 :Method for monitoring in peptide synthesis
发明人：SALISBURY STEPHEN; TREMEER JOHN; OWEN DAVID; DAVIES JOHN
权利人:SALISBURY STEPHEN; TREMEER JOHN; OWEN DAVID; DAVIES JOHN
摘要:A method for monitoring the reaction between an activated carboxylic acid derivative and an amine, such as the formation of a peptide bond in peptide synthesis, whereby an inert anionic dye component and an inert cationic component are included in the reaction system, in small relative amounts compared to the carboxylic acid derivative. The distribution of the dye component to the cationic component, when separated from the amine component, is monitored and at a given maximum value indicates a substantially quantitative reaction.
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主要参考文献
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.合成参考文献
参考文献:10.1007/bf02442600|10.1007/s10989-005-3968-8|10.1023/b:lips.0000049132.01206.4c
摘要:Tantry SJ, Suresh Babu VV. 9-Fluorenylmethyl chloroformate (Fmoc-Cl) as a useful reagent for the synthesis of pentafluorophenyl, 2,4,5-trichlorophenyl, pentachlorophenyl, p-nitrophenyl, o-nitrophenyl and succinimidyl esters of Nα-urethane protected amino acids. International Journal of Peptide Research and Therapeutics. 2003 Sep;10(5-6):655–62. doi: 10.1023/b:lips.0000049132.01206.4c.
参考文献:10.1007/0-306-46862-x_350
摘要:Jackson PL, Villain M, Galin FS, Krishna NR, Blalock JE. Differences in encephalitogenicity in MBP peptide 68-88 due to histidine racemization. 2002. In: Peptides Frontiers of Peptide Science. : Kluwer Academic Publishers; 2002.
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