CAS: 944401-55-2; 4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyrimidin-2-Amine

英文名称4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Pyrimidin-2-Amine
中文名称2-氨基-4-甲基嘧啶-5-硼酸频哪酯
IUPAC名称4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine
其它别名2-氨基-4-甲基嘧啶-5-硼酸频哪酯; 4-甲基-5-(4,4,5,5-四甲基-1,3,2-二氧杂环戊硼烷-2-基)嘧啶-2-胺; 4-Methyl-2-Aminopyrimidine-5-Boronic Acid Pinacol Ester
CAS编号944401-55-2
MFCD编号:MFCD18072554
分子式:C11H18BN3O2
分子量:235.09
产品CID: 1994910
产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物

相似结构搜索
InChIKey: SYJMHOBGFXCKRG-UHFFFAOYSA-N
InChI=1S/C11H18BN3O2/c1-7-8(6-14-9(13)15-7)12-16-10(2,3)11(4,5)17-12/h6H,1-5H3,(H2,13,14,15)…
计算化学: 氢键受体数5.0氢键供体数1.0可旋转键数1.0

相似化合物

2377611-40-8 1370001-96-9 1430233-43-4

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明H303+H313+H333

上下游产品

CAS号17321-93-6 2-氨基-4-甲基-5-溴嘧啶 | CAS号73183-34-3 双戊酰二硼 | CAS号108-52-1 2-氨基-4-甲基嘧啶

合成工艺路线路线简述

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Solvents: 1,4-Dioxane; 20 Min,Rt1.2 Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu...; Rt -> 115 °C; 18 H,115 °C
标题:Preparation Of Tricyclic N-Heteroaryl Compounds As Pi3K Inhibitors For Treatment Of Cancer
参考文献:World Intellectual Property Organization]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Solvents: 1,4-Dioxane; 20 Min,Rt1.2 Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu...; 18 H,Rt -> 115 °C
标题:Preparation Of Purine Derivatives With Pi3K Inhibitory Activity And Methods Of Use Thereof
参考文献:World Intellectual Property Organization]

17321-93-6 + 73183-34-3 = 944401-55-2 + 108-52-1
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 16 H,115 °C
标题:Mechanistic Target Of Rapamycin Signaling Pathway Inhibitors,Therapeutic Applications,And Preparation
参考文献:World Intellectual Property Organization]

17321-93-6 + 73183-34-3 = 944401-55-2 + 108-52-1
反应条件:1.1 Reagents: Potassium Acetate Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu... Solvents: 1,4-Dioxane; 18 H,115 °C
标题:Identification Of Nvp-Bkm120 As A Potent,Selective,Orally Bioavailable Class I Pi3 Kinase Inhibitor For Treating Cancer
作者:Burger,Matthew T.; Pecchi,Sabina; Wagman,Allan; Ni,Zhi-Jie; Knapp,Mark; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2011 卷标:2(10) 页码:774-779]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Solvents: 1,4-Dioxane; 20 Min,Rt1.2 Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu...; 18 H,Rt -> 115 °C
标题:Discovery Of Clinical Development Candidate Gdc-0084,A Brain Penetrant Inhibitor Of Pi3K And Mtor
作者:Heffron,Timothy P.; Ndubaku,Chudi O.; Salphati,Laurent; Alicke,Bruno; Cheong,Jonathan; Et Al
参考文献:Acs Medicinal Chemistry Letters 日期:2016 卷标:7(4) 页码:351-356]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; 20 Min,Rt; 18 H,Rt -> 115 °C
标题:Preparation Of Dioxino- And Oxazin-[2,3-D]Pyrimidine Pi3K Inhibitors For Treatment Of Cancer And Other Pi3K-Mediated Disorders
参考文献:World Intellectual Property Organization]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; Overnight,85 °C
标题:Deazapurines,Thienopyrimidines And Furopyrimidines As Phosphoinositide 3-Kinase Inhibitors With A Zinc Binding Moiety And Their Preparation And Use In The Treatment Of Diseases
参考文献:United States]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Catalysts: [1,1′-Bis(Diphenylphosphino)Ferrocene]Dichloropalladium Solvents: 1,4-Dioxane; Overnight,85 °C
标题:Treatment Of Cancers Having K-Ras Mutations Using Pi3 Kinase And Hdac Inhibitors And Preparation Of Bifunctional Thienopyrimidine Compounds That Inhibit Both Enzymes
参考文献:World Intellectual Property Organization]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Catalysts: Palladium Chloride,1,1-Bis(Diphenylphosphino)Ferrocene Solvents: Dimethylformamide; 15 Min,50 °C; 50 °C -> Rt1.2 Reagents: Potassium Acetate; 16 H,95 °C
标题:Preparation Of Pyrimidine Derivatives As Inhibitors Of Phosphatidylinositol 3-Kinase
参考文献:United States]

17321-93-6 + 73183-34-3 = 944401-55-2
反应条件:1.1 Reagents: Potassium Acetate Solvents: 1,4-Dioxane; 15 Min,Rt1.2 Catalysts: Dichloro[1,1′-Bis(Diphenylphosphino)Ferrocene]Palladium(Ii) Dichloromethane Addu...; 18 H,115 °C; 115 °C -> Rt
标题:Pyrimidine Derivatives Used As Pi-3 Kinase Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
参考文献:World Intellectual Property Organization

2-氨基-4-甲基嘧啶置于1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 N-溴代丁二酰亚胺(Nbs),Potassium Acetate体系中,用 1,4-二氧六环,氯仿作为反应溶剂,化学反应 36.0H,反应生成 2-氨基-4-甲基嘧啶-5-硼酸频哪酯
参考文献: Purine Pi3K Inhibitor Compounds And Methods Of Use[fr] Composés Inhibiteurs De La Pi3K De Type Purine Et Procédés D'Utilisation
标题: Purine Pi3K Inhibitor Compounds And Methods Of Use[fr] Composés Inhibiteurs De La Pi3K De Type Purine Et Procédés D'Utilisation
摘要:公式i的嘌呤化合物,包括立体异构体,几何异构体,互变异构体,溶剂化合物,代谢物和其药用可接受盐,可用于抑制脂质激酶,包括p110 Alpha和pi3K的其他同工酶,并用于治疗由脂质激酶介导的癌症等疾病.揭示了使用公式i的化合物在哺乳动物细胞中进行体外,体内和体内诊断,预防或治疗这类疾病或相关病理状况的方法.