CAS: 85199-06-0; 2,5-Dimethylphenylboronic Acid

该化合物是一种含有分子式C8H11BO2的碳酸衍生物,它是有机合成的多用途中间体,特别是在铃木-宫浦交叉反应中,能够形成用于制药和材料科学应用的碳-碳债券.在2和5个位置上存在甲基组,会增强消毒和电子特性,提高组合反应的选择性.这种复合体在标准条件下表现出良好的稳定性,并显示出与一系列催化剂和子质的兼容性.其高纯度和一贯性能使得它成为研究和工业应用的可靠选择,需要确切的芳香系统功能化.

英文名称2,5-Dimethylphenylboronic Acid
中文名称2,5-二甲基苯硼酸
IUPAC名称(2,5-dimethylphenyl)boronic acid
其它别名2,5-二甲苯基硼酸
CAS编号85199-06-0
MFCD编号:MFCD01863525
EINECS号:677-065-2
分子式:C8H11BO2
分子量:149.98
产品CID: 1846828
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: OOMZKLJLVGQZGV-UHFFFAOYSA-N
InChI=1S/C8H11BO2/c1-6-3-4-7(2)8(5-6)9(10)11/h3-5,10-11H,1-2H3…
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn,Xi
安全声明37/39-26-36/37
危险类别码36/37/38-22
WGK Germany3

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

合成目标产物 2,5-Dimethylphenylboronic Acid 主要起始原料 Trimethyl Borate And 2,5-Dimethylbromobenzene And Water
553-94-6 = 85199-06-0
反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Hexane; -70 °C; 30 Min,-70 °C; 90 Min,-70 °C -> Rt; Rt -> -70 °C1.2 Reagents: Tributyl Borate; 45 Min,-70 °C; 2 H,Rt1.3 Solvents: Water; Rt
标题:Synthesis And Characterization Of Highly Soluble Phenyl-Substituted Poly(P-Phenylenevinylenes)
作者:Johansson,D. Mikael; Srdanov,Gordana; Yu,Gang; Theander,Mathias; Inganaes,Olle; Et Al
参考文献:Macromolecules 日期:2000 卷标:33(7) 页码:2525-2529]

553-94-6 = 85199-06-0
反应条件:1.1 Reagents: Butyllithium Solvents: Diethyl Ether,Water; Rt -> -78 °C; -78 °C; -78 °C -> Rt; 1 H,Rt; Rt -> -78 °C1.2 Reagents: Triethyl Borate; -78 °C; 12 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water
标题:Synthesis And Characterization Of Organic Light-Emitting Copolymers Containing Naphthalene
作者:Kim,Jung-Sik; Heo,Jun; Kang,Pengtao; Kim,Jin Hak; Jung,Sung Ouk; Et Al
参考文献:Macromolecular Research 日期:2009 卷标:17(2) 页码:91-98]

553-94-6 = 85199-06-0
反应条件:1.1 Reagents: Magnesium Solvents: Tetrahydrofuran; 4 H,Reflux; Reflux -> -78 °C1.2 Reagents: Trimethyl Borate Solvents: Tetrahydrofuran; -78 °C; 24 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; 24 H,Rt
标题:New Phenyl-Substituted Ppv Derivatives For Polymer Light-Emitting Diodes-Synthesis,Characterization And Structure-Property Relationship Study
作者:Chen,Zhi-Kuan; Lee,Nancy Hoi Sim; Huang,Wei; Xu,Yi-She; Cao,Yong
参考文献:Macromolecules 日期:2003 卷标:36(4) 页码:1009-1020]

553-94-6 = 85199-06-0
反应条件:1.1 Reagents: Magnesium Solvents: Diethyl Ether; Rt; Heated; 30 Min,Reflux; Reflux -> -70 °C1.2 Reagents: Trimethyl Borate; 30 Min,-70 °C; 5 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water1.4 Reagents: Sodium Hydroxide Solvents: Water; Basified1.5 Reagents: Hydrochloric Acid Solvents: Water; Acidified
标题:Synthesis And Optoelectronic Properties Of Alternating Benzofuran/terfluorene Copolymer With Stable Blue Emission
作者:Zhang,Haichang; Guo,Erqian; Fang,Yujie; Ren,Peihua; Yang,Wenjun
参考文献:Journal Of Polymer Science 日期:2009 卷标:47(20) 页码:5488-5497]

553-94-6 = 85199-06-0
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran1.2 Reagents: Triisopropyl Borate1.3 Reagents: Hydrochloric Acid Solvents: Water
标题:Directed Electrophilic Cyclizations: Efficient Methodology For The Synthesis Of Fused Polycyclic Aromatics
作者:Goldfinger,Marc B.; Crawford,Khushrav B.; Swager,Timothy M.
参考文献:Journal Of The American Chemical Society 日期:1997 卷标:119(20) 页码:4578-4593]

34202-99-8 = 85199-06-0
反应条件:1.1 Reagents: Water,Diborane Catalysts: Tetrahydrofuran Solvents: Water
标题:Reactions Of Organothallium Compounds With Diborane
作者:Pickles,Geoffrey M.; Spencer,Terence; Thorpe,F. Gordon; Ayala,Alicia D.; Podesta,Julio C.
参考文献:Journal Of The Chemical Society 日期:1982 卷标:(12) 页码:2949-51

海关参考信息

2902300000-甲苯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:CN-102731370-B
优先权日:2012-07-13
标题:Preparation method of ionic liquid and method for catalyzing synthesis of biphenyl compounds using ionic liquid palladium carbon

专利号:CN-104692985-B
优先权日:2013-12-06
标题 :Palladium-catalyzed synthesis of Î±-aryl, heteroaryl or alkenyl-Î±,Î±-difluoroallyl structures

专利号:CN-104692985-A
优先权日:2013-12-06
标题 :Method for palladium-catalyzed synthesis of Î±-aryl, heteroaryl or alkenyl-Î±,Î±-difluoroallyl structures

专利号:CN-108558677-A
优先权日:2018-04-13
标题 :A kind of highly convoluted cross-conjugated organic compound and its synthesis method

专利号:CN-102643152-A
优先权日:2012-05-14
标题:A green synthesis method of nano-palladium catalyzed biphenyl compounds