CAS: 752253-39-7; (S)-4-(2-Chloro-4-Methoxy-5-Methylphenyl)-N-(2-Cyclopropyl-1-(3-Fluoro-4-Methylphenyl)Ethyl)-5-Methyl-N-(Prop-2-Yn-1-yl)Thiazol-2-Amine
该化合物是一个复杂的有机化合物,其特点是多功能结构,具有多功能性,具有一种复杂的有机化合物,它是一个五人组成的含有硫磺和氮的环形化合物,有助于其生物活动. 各种分组的存在,包括一个氯类,甲氧氧基化合物组和多种甲基组,表明其与生物目标相互作用的潜在性和能力.环丙基和氟醚组可能增强它的药用特性,可能影响其结合性和选择性.这种化合物有可能因其治疗潜力,特别是在医药化学或药物开发等领域,其复杂的结构可能影响其再生性和生物性,因此决定其重要的合成化合物的稳定性.
- 英文名称(S)-4-(2-Chloro-4-Methoxy-5-Methylphenyl)-N-(2-Cyclopropyl-1-(3-Fluoro-4-Methylphenyl)Ethyl)-5-Methyl-N-(Prop-2-Yn-1-yl)Thiazol-2-Amine
- 中文名称(S)-4-(2-氯-4-甲氧基-5-甲基苯基)-N-(2-环丙基-1-(3-氟-4-甲基苯基)乙基)-5-甲基-N-(丙酸-2-炔-1-基)噻唑-2-胺
- IUPAC名称(S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine
- 其它别名4-(2-Chloro-4-Methoxy-5-Methyl-Phenyl)-N-[(1S)-2-Cyclopropyl-1-(3-Fluoro-4-Methyl-Phenyl)Ethyl]-5-Methyl-N-Prop-2-Ynyl-1,3-Thiazol-2-Amine ; 4-(2-Chloro-4-Methoxy-5-Methylphenyl)-N-[(1S)-2-Cyclopropyl-1-(3-Fluoro-4-Methylphenyl)Ethyl]-5-Methyl-N-Prop-2-Yn
- CAS编号752253-39-7
- MFCD编号:MFCD07772351
- FDA UNII编号:MFT24BX55I
- 分子式:C27H28ClFN2OS分子量:483.05
- 产品CID: 1744072
- 同类组份化合物CAS752253-39-7 (HCl)752253-39-7 (free base)
- 产品分类Inhibitors/Agonists → GPCR/G Protein → CRF Receptor
- 相似结构搜索
- InChIKey: IEAKXXNRGSLYTQ-DEOSSOPVSA-N
- IEAKXXNRGSLYTQ-DEOSSOPVSA-N
- 计算化学: 氢键受体数5.0氢键供体数*可旋转键数8.0
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901292000-乙炔
2902600000-乙苯
2903919090-氯苯
2905110000-甲醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-114423755-A
优先权日:2019-09-13
标 题:Process for the synthesis of valbenazines
专利号:MX-2022015551-A
优先权日:2018-12-07
标题 :SYNTHESIS METHODS FOR THE PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-M ETHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5 -METHYL-N-PROP-2-INYL-1,3-THIAZOLE-2-AMINE.
专利号:CN-115087647-A
优先权日:2018-12-07
标 题:For the preparation of 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl) ) ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine synthesis method
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Philbert J, Beeské S, Belzung C, Griebel G. The CRF₁ receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: comparison with paroxetine and d-cycloserine. Behav Brain Res. 2015 Feb 15;279:41-6. doi: 10.1016/j.bbr.2014.11.006. Epub 2014 Nov 12. doi: 10.1016/j.bbr.2014.02.024. Epub 2014 Feb 22. doi: 10.1007/s00213-013-3315-2. Epub 2013 Nov 2. doi: 10.1007/s00213-013-3020-1. Epub 2013 Feb 14. doi: 10.1016/j.pbb.2012.05.013. Epub 2012 May 31. doi: 10.1210/me.2011-1202. Epub 2012 Feb 2. doi: 10.1007/s00213-011-2366-5. Epub 2011 Jun 4. doi: 10.1038/mp.2011.48. Epub 2011 May 3.
10: Knapp DJ, Whitman BA, Wills TA, Angel RA, Overstreet DH, Criswell HE, Ming Z, Breese GR. Cytokine involvement in stress may depend on corticotrophin releasing factor to sensitize ethanol withdrawal anxiety. Brain Behav Immun. 2011 Jun;25 Suppl
1:S146-54. doi: 10.1016/j.bbi.2011.02.018. Epub 2011 Mar 4.
合成参考文献
摘要:Kleemann A., Kutscher B., Reichert D., Bossart M., Pharmaceutical Substances, Thieme [Online], Stuttgart, (2026).
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