CAS: 611-64-3; 9-Methylacridine

上下游产品

9-methyl-9,10-dihydroacridine N,N-diphenylacetamide (E)-3-Ureido-but-2-enoic acid ethyl ester 3-acridin-9-yl-1,1,1-trichloro-propan-2-ol 9,9‐dimethyl‐10H‐acridine 9-(3-nitro-2-phenyl-propyl)-acridine (E)-9-(4-aminostyryl)acridine N'-acridin-9-ylmethylene-N,N-diethyl-p-phenylenediamineN'-acridin-9-ylmethylene-N,N-diethyl-p-phenylenediamine

📜亚氨基芪 950.0 °C,1.2 Pa 条件下,反应 0.5H,以60%的收率获得产物9-甲基吖啶
参考文献:苯并[b,F] Azepin-5-Yl自由基的热环收缩:吡咯并[3,2,1-Jk]咔唑的新途径.
标题:苯并[b,F] Azepin-5-Yl自由基的热环收缩:吡咯并[3,2,1-Jk]咔唑的新途径.
摘要:N-烯丙基-或n-苄基二苯并[b,F]氮杂在750至950摄氏度的温度下进行快速真空热解(fvp),得到吡咯并[3,2,1-Jk]咔唑为主要产物.环收缩的机理涉及二苯并ze庚因-1-基自由基的形成,随后是环过环的攻击和环化的2-(吲哚-1-基)苯基的自由基的形成.通过两种不同方法独立反应生成2-(吲哚-1-基)苯基自由基可支持该机理,并且使用1-(2-硝基苯基)吲哚作为自由基反应生成剂可优化合成吡咯并[3,2,1-Jk]咔唑(从吲哚分两步获得的总收率为54%).第一取代的吡咯并[3,2,1-Jk]咔唑已经通过fvp方法合成,并且还通过母体化合物与亲电试剂的反应合成,产生了一系列的4-取代的吡咯并咔唑.
DOI:10.1021/jo800637U

专利信息

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-5110923-A
优先权日:1990-07-18
标题 :Method for preparing 5-chlorocarbonyl-5h-dibenz(b,f)azepine
发明人：PALITSCH PETER; CZERNOTZKY KLAUS; RICHTER ERHARD; KREHER BERNDT; KLUMP WILIFRIED; MUELLER RAINER
权利人:DRESDEN ARZNEIMITTEL
摘要:The invention is directed to a process for the synthesis of 5-chlorocarbonyl-5H-dibenz[b,f]azepine, which is the precursor for the industrial scale synthesis of 5-carbamoyl-5H-dibenz[b,f]azepine. The latter substance is used as pharmaceutical compound. In the process phosgene is passed into a suspension of iminostilbene in an inert solvent at 20° C.-60° C. until the iminostilbene reacted to form an almost equimolar mixture of 5-chlorocarbonyl-5H-dibenz[b,f]azepine and iminostilbene hydrochloride, and then iminostilbene is released from the iminostilbene hydrochloride by the addition of an aqueous base. The iminostilbene so released is also made available for a complete phosgenation while an acidic reaction environment is maintained. After the iminostilbene reacted completely, the reaction mixture is heated slowly to 20° C.-90° C. with stirring and is detoxified by the hydrochloric acid that is formed.

专利号:JP-H02502916-A
优先权日:1987-12-31
标 题:Synthesis of 1,2-dioxetanes and their intermediates

专利号:US-2014350261-A1
优先权日:2011-11-08
标 题 :Method for catalytic asymmetric synthesis of optically active isoxazoline compound, and optically active isoxazoline compound

专利号:TW-201028384-A
优先权日:2008-12-15
标 题 :Stereoselective synthesis of piperidine derivatives

专利号:WO-2013069731-A1
优先权日:2011-11-08
标题 :Method for catalytic asymmetric synthesis of optically active isoxazoline compound, and optically active isoxazoline compound