CAS: 61-57-4; Niridazole

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CAS号28118-54-9 2-甲氧基咪唑啉 | CAS号3034-48-8 2-溴-5-硝基噻唑 | CAS号37422-15-4 2-(2-methylsulf...

📜2-(2-甲基硫烷基-4,5-二氢-咪唑-1-基)-5-硝基-噻唑置于双氧水,溶剂黄146体系中,化学反应生成 尼立达唑
参考文献:Kutter; Machleidt; Reuter,Arzneimittel-Forschung/drug Research,1972,Vol. 22,# 6,P. 1045-1054
标题:Kutter; Machleidt; Reuter,Arzneimittel-Forschung/drug Research,1972,Vol. 22,# 6,P. 1045-1054

专利信息

专利号:US-5847150-A
优先权日:1996-04-24
标题 :Solid phase and combinatorial synthesis of substituted 2-methylene-2, 3-dihydrothiazoles and of arrays of substituted 2-methylene-2, 3-dihydrothiazoles
发明人：DORWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted 2-methylenethiazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 2-methylenethiazoles are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide under acidic conditions yields differently substituted, support-bound 2-methylene-2,3-dihydrothiazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 2-methylenethiazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-9422232-B2
优先权日:2009-07-09
标题:Reductive release probes containing a chemoselectively cleavable α-azidoether linker and methods of use thereof
发明人：FRANZINI RAPHAEL M; KOOL ERIC TODD
权利人:FRANZINI RAPHAEL M; KOOL ERIC TODD; UNIV LELAND STANFORD JUNIOR
摘要:Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

专利号:EP-1575990-B1
优先权日:2002-09-08
标题:Solid phase bound PNA-dimers and their synthesis
发明人：CASALE RALPH A; COULL JAMES M; DEY SUBHAKAR; KOWALCZYK BRUCE A; GAN KEVIN Z
权利人:APPLERA CORP
摘要:This invention pertains to the field of PNA dimer and PNA oligomer synthesis.

专利号:EP-1575990-A4
优先权日:2002-09-08
标 题:METHODS, COMPOSITIONS AND BANKS RELATING TO THE SYNTHESIS OF DIMER AND OLIGOMER OF ANP

专利号:WO-2013112215-A1
优先权日:2012-01-24
标题:Synthesis, dye functionalization and bioimaging of polymeric nanocapsules
发明人：BALASUBRAMANIAN RAMJEE; OSGOOD CHRISTOPHER; MAHADEVAN KALPANA; PATTHIPATI VANKATA SURESH; HAN SANGBUM; SWANSON JAMES
权利人:OLD DOMINION RES FOUNDATION; BALASUBRAMANIAN RAMJEE; OSGOOD CHRISTOPHER; MAHADEVAN KALPANA; PATTHIPATI VANKATA SURESH; HAN SANGBUM; SWANSON JAMES
摘要:The present invention relates to functionalized polymeric nanocapsules, methods of making thereof and use thereof in. bio-imaging systems. I n particular, the functionalized nanocapsules of the invention may be formed by thiol -en e photopolymerization of resorcinarene derviatives, wherein the resulting nanocapsule products are further functionalized. with moieities having properties, such as, water solubility and/or fluorescence.

专利号:WO-9740030-A1
优先权日:1996-04-24
标 题:Solid phase and combinatorial synthesis of substituted 2-methylene-2,3-dihydrothiazoles and of arrays of substituted 2-methylene-2,3-dihydrothiazoles