专利号:US-6924385-B2 优先权日:2002-11-18 标 题:Method for synthesis of aliphatic isocyanates from aromatic isocyanates 发明人:LETTMANN CHRISTIAN; KOHLSTRUK STEPHAN; STOCHNIOL GUIDO; SPYROU EMMANOUIL 权利人:DEGUSSA 摘要:The invention relates to a method for synthesis of aliphatic isocyanates from aromatic isocyanates in substantially 3 stages. In particular, the invention relates to a method for synthesis of bis{4-isocyanatocyclohexyl}methane (H 12 MDI) from bis{4-isocyanatophenyl}methane (MDI). More especially, the invention relates to a method for synthesis of H 12 MDI with a trans-trans isomer content of <30%, preferably of <20%, particularly preferably of 5 to 15%.
专利号:US-2003162992-A1 优先权日:2001-12-14 标 题 :Preparation of intermediates useful in the synthesis of antiviral nucleosides 发明人:WATANABE KYOICHI A; DU JINFA 摘要:The present invention is an efficient process for the manufacture of α-acyloxyacetaldehyde, a key intermediate in the synthesis of 1,3-oxathiolane and 1,3-dioxolane nucleosides.
专利号:US-6472534-B2 优先权日:1999-10-21 标 题:Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors 发明人:BORER BENNETT C; ZOOK SCOTT E; BUSSE JULIETTE K 权利人:AGOURON PHARMA 摘要:Methods for the preparation of chemical intermediates in the synthesis of HIV-protease inhibitors related to and including nelfinavir mesylate are disclosed. The method of this invention comprises converting tetrohydran derivatives into oxazolines to provide key reaction intermediates for the preparation of nelfinavir. Also disclosed is a method for the preparation of a chiral amino alcohol from an epoxy-tetrahydrofuran.
专利号:US-6495710-B2 优先权日:2000-01-14 标题:Synthesis and use of dimethyl 1,5-naphthalenedicarboxlyates and intermediates therefrom 发明人:MACEK JOHN A; ROSEN BRUCE I; HOLZHAUER JUERGEN K; BRAMLET JOHN S; LILLWITZ LARRY D; SCHNEIDER DAVID J; LANG LAWRENCE L; PASCHKE EDWARD E; WEIS JOHN M; VISWANATH YENAMANDRA; SAKELLARIDES STEFANOS L 权利人:BP CORP NORTH AMERICA INC 摘要:The synthesis of dimethyl-1,5-naphthalenedicarboxylate and polymers and articles formed therefrom is disclosed, as well as applications for dimethyl-1,5-naphthalenedicarboxylate, its corresponding acid 1,5-NDA, and various synthesis intermediates.
专利号:US-6512086-B2 优先权日:2000-07-25 标 题 :Process for preparation of organosilicon compositions 发明人:GRECO ALBERTO; AUSILIO ANTONIO; POZZI ENRICO 权利人:MAPEI SPA 摘要:Process for the preparation of fluid organosilicon compounds usable in adhesive, coating and sealant formulations is described. The process includes the synthesis of organosilicon prepolymer compositions starting from unsaturated polyurethanes obtained in turn from unsaturated monoalcohol polyethers and diisocyanates with a controlled NCO/OH ratio, to which chlorosilanes are added in the presence of methyl or ethyl orthoformates. These organosilicon compositions are able to cross-link through silicon-alkoxy end groups of the type:
专利号:US-8759469-B2 优先权日:2007-07-25 标题 :Synthesis of urethanes and polyurethanes catalysed by carbenes 发明人:MIGNANI GERARD; DESTARAC MATHIAS; TATON DANIEL; GNANOU YVES; BACEIREDO ANTOINE; KATO TSUYOSHI; BONNETTE FABIEN; SIVASANKARAPILLAI GOPAKUMAR 权利人:MIGNANI GERARD; DESTARAC MATHIAS; TATON DANIEL; GNANOU YVES; BACEIREDO ANTOINE; KATO TSUYOSHI; BONNETTE FABIEN; SIVASANKARAPILLAI GOPAKUMAR; Vencorex Frence; CENTRE NAT RECH SCIENT 摘要:The present invention relates to a process for preparing a compound comprising at least a urethane group —HN—C(â•?O)—O, said process comprising a step (E) in which a compound (I) comprising at least an isocyanate functional group —Nâ•?Câ•?O is reacted with an organic compound (II) carrying at least a hydroxyl group —OH, said reaction being carried out in a presence of a carbene (III) used as a catalyst.
摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 774. 摘要:Barsegyan, Y. A.; Vil’, V. A.; Tomkinson, N. C. O.; Terent’ev, A. O., Science of Synthesis Knowledge Updates, (2022) 1, 239.