CAS: 5398-77-6; 4-(Methylsulfonyl)Benzaldehyde

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CAS号3446-89-7 甲硫基苯甲醛 | CAS号20277-69-4 甲烷亚磺酸钠 | CAS号459-57-4 对氟苯甲醛 | CAS号104-88-1 对氯苯甲醛 | CAS号22821-77-8 4-甲砜基苯甲醇 | CAS号100515-19-3 1-(1,1-dimethox... | CAS号3446-90-0 4-甲硫基苄醇 | CAS号7722-84-1 过氧化氢 | CAS号3185-99-7 对甲砜基甲苯 | CAS号73231-34-2 氟苯尼考 | CAS号5345-30-2 (2E)-3-[4-(甲基磺酰... | CAS号53606-06-7 4-甲基磺酰苄溴 | CAS号10297-73-1 4-甲砜基苯乙酮 | CAS号3570-98-7 2,2-dichloro-N-... | CAS号3576-68-9 2-[(2,2-dichlor... | CAS号3571-08-2 2-chloro-N-(2-h... | CAS号15318-45-3 甲砜霉素 | CAS号125872-64-2 3-(4-methylsulf... | CAS号22821-77-8 4-甲砜基苯甲醇

4-甲基茴香硫醚置于air体系中,用61%的收率获得产物对甲砜基苯甲醛
参考文献:一种对甲砜基苯甲醛的制备方法
标题:一种对甲砜基苯甲醛的制备方法
摘要:本发明公开一种对甲砜基苯甲醛的制备方法.本发明的对甲砜基苯甲醛的制备方法是:首先如式所示在惰性气体保护下,在溶剂中化合物2与甲硫醇钠在催化剂作用下反应,再将得到的产物与水混合,在催化剂作用下进行氧化反应,产物经水中析晶过滤,得到目标产物对甲砜基苯甲醛.本发明的方法步骤简短,原材料价格低廉;利用固定床反应器的高效热质传递特性,使本发明显著区别于现有釜式合成工艺;本发明的催化剂高催化活性使对甲硫基甲苯转化完全,催化剂可重复回收套用,生产过程绿色环保,可减少三废排放,更适合于工业化生产.

专利信息

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-2023183175-A1
优先权日:2020-03-16
标 题:Method for preparing intermediate for use in synthesis of florfenicol and compounds prepared thereby
发明人：LI WENSEN; ZHANG WENQI
权利人:HEADING NANJING PHARMTECHNOLOGIES CO LTD
摘要:The present invention provides a method for preparing an intermediate of florfenicol, comprising: reacting p-methylthiobenzaldehyde with isocyanoacetate under catalysis of a chiral catalyst. In the reaction, the chiral product is oxidized to form a methylsulfone-substituted product which is subsequently deformylized to obtain the intermediate. In the method of the present invention, the chiral center of the intermediate is directly generated in the first step of reaction, and the yield of the first step reaches 75%-80%, which is significantly higher than the conventional chiral resolution methods (about 40% yield), and the product has high chiral purity. The method of the present invention does not use anhydrous copper sulfate that pollutes the environment, which reduces the environmental pressure. The compound of p-methylthiobenzaldehyde and the compound of isocyanoacetate are used to react to form a chiral intermediate, which has higher material availability and efficiency than linear synthesis methods.

专利号:US-7220884-B2
优先权日:2004-02-10
标 题 :Hydroaminomethylation of olefins
发明人：BRIGGS JOHN R; WHITEKER GREGORY T; KLOSIN JERZY
权利人:DOW GLOBAL TECHNOLOGIES INC
摘要:The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.

专利号:US-2009149657-A1
优先权日:2005-11-09
标 题:Process for the synthesis of intermediates of chloramphenicol or its analogues

专利号:US-5352832-A
优先权日:1992-12-18
标题 :Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
发明人：WU GUANG-ZHONG; TORMOS WANDA I
权利人:SCHERING CORP
摘要:The present invention comprises a process for the asymmetric synthesis of florfenicol, thiamphenicol or chloramphenicol, from a derivative of trans-cinnamic acid, comprising the steps: n (a) converting the acid to an acid chloride using a chlorinating agent, and reducing the acid chloride to a trans allylic alcohol with a reducing agent; n (b) asymmetrically epoxidizing the allylic alcohol of step (a), by reacting with t-butylhydroperoxide in the presence of a chiral epoxidation catalyst prepared from titanium (IV) isopropoxide and L-diisopropyltartaric acid, to form a chiral epoxide; n (c) regioselectively opening the epoxide of step (b) by sequentially treating with sodium hydride, zinc chloride and dichloroacetonitrile to form an oxazoline; n (d) stereoselective inversion/isomerization of the oxazoline of step (c) by sequentially treating with: (i) a lower alkylsulfonyl chloride and a tertiary amine base; (ii) sulfuric acid and water; (iii) an alkali metal hydroxide; to form an oxazoline; n (e) optionally treating the oxazoline of step (d) with a fluorinating agent, for preparing florfenicol, then hydrolyzing with acid. n In an alternative embodiment, the present invention comprises a process for isomerizing of the S,S-isomer of florfenicol to the R,S-isomer (I) by sequentially treating with: (i) a lower alkylsulfonyl chloride and a tertiary amine base; (ii) sulfuric acid and water; (iii) an alkali metal hydroxide. n The present invention further comprises a process for regioselectively opening an epoxide to form a threo-oxazoline.