CAS: 51-45-6; 2-(1H-Imidazol-4-yl)Ethan-1-Amine

相似化合物

56-92-8 195053-92-0 98870-64-5

上下游产品

4-(2-chloroethyl)-1H-imidazole 4-cyanomethylimidazole mon°Cloridrato di 2-(2-tiono-4-imidazolin-4-il)etilamina D,L-histidine[2-(1H-Imidazol-4-yl)-ethyl]-dimethyl-amine pyridine4,5,6,7-tetrahydro-1H-imidazo4,5-cpyridine 5,6,7,8-tetrahydro-5-oxoimidazo[1,5-c]pyrimidine (3)H-imidazol-4-yl)-ethylamino]-ethyl}-phenol4-{2-[2-(1(3)H-imidazol-4-yl)-ethylamino]-ethyl}-phenol

4(5)-腈甲基咪唑置于氨,氢气体系中,用 甲醇 作为反应溶剂,80.0 °C,4.0 Mpa 条件下,反应 24.0H,以69%的收率获得产物组胺
参考文献:稳定且可重复使用的镍基纳米颗粒,用于将腈类普遍和选择性氢化成胺
标题:稳定且可重复使用的镍基纳米颗粒,用于将腈类普遍和选择性氢化成胺
摘要:二氧化硅负载的超小 Ni 纳米颗粒允许在温和条件下将各种腈类普遍和选择性地氢化为伯胺.通过煅烧由 Ni(Ii) 反应生成的模板材料)硝酸盐和胶体二氧化硅在空气下,随后在分子氢存在下还原,制备最佳催化剂.制备的负载型纳米颗粒稳定,使用方便,易于回收利用.最佳催化剂材料的适用性通过对超过 110 种不同的脂肪族和芳香族腈(包括功能化和工业相关底物)进行氢化来证明.具有挑战性的杂环腈,特别是氰基吡啶,以非常好的收率提供了相应的伯胺.所得胺可作为制备众多生命科学产品和聚合物的重要前体和中间体.
DOI:10.1039/d2Sc02961H

专利信息

专利号:US-5919969-A
优先权日:1996-06-05
标 题 :Synthesis of yellow couplers
发明人：CRAWLEY MICHAEL W
权利人:EASTMAN KODAK CO
摘要:The invention provides a method of synthesis of a image-dye forming coupler of formula (I) wherein X is a substituent linked to the coupler by an atom of oxygen, sulfur or nitrogen R1 is an alkyl or aryl group, R2 is a hydrogen atom or an alkyl group; R3 to R7 are the same or different and selected from a hydrogen atom and substituent groups; which method comprises the reaction of a compound of formula (II) wherein R and R1 are the same or different and are as defined above for R1 and X is as defined above with a compound of formula (III) wherein R2 to R7 are as defined above, in the presence of an inert organic solvent.

专利号:WO-2025136243-A1
优先权日:2023-12-20
标题:Mechanochemical synthesis of histamine h1-receptor antagonists
发明人：AYDONAT SIMAY; OZEL MERTCAN; YIGITBASI JOANNA MARIANNA; BAYTEKIN BILGE; COLACINO EVELINA
权利人:IHSAN DOGRAMACI BILKENT UNIV; CENTRE NAT RECH SCIENT
摘要:The present invention relates to mechanochemical synthesis of histamine antagonists which are benzhydryl ethers and unsymmetrically disubstitutes piperazines and salts thereof. Said antihistamine active pharmaceutical ingredients can be diphenhydramine hydrochloride, cyclizine hydrochloride and diphenylpyraline hydrochloride. These antihistamines are used in the treatment of allergies, hives, hay fever (allergic rhinitis), conjunctivitis, reactions to insect bites and sings, nausea, motion sickness, insomnia.

专利号:US-6620942-B2
优先权日:1998-12-23
标题 :Synthesis of histamine dihydrochloride
发明人：YEH WEN-LUNG; ANTCZAK CASIMIR; MCGOLRICK JEFFRY DAVID; ROTH MICHAEL JOSEPH; WRONA MARK
权利人:MAXIM PHARMACEUTICALS
摘要:The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L -histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.

专利号:US-6803468-B2
优先权日:2000-08-29
标 题 :Process for the synthesis of n-(5-methylnicontinoyl)-4 hydroxypiperidine, a key intermediate of rupatadine
发明人：KUMAR YATENDRA; PRASAD MOHAN; SINGH SHAILENDRA KUMAR
权利人:RANBAXY LAB LTD
摘要:The present invention relates to an improved and industrially advantageous process for the preparation of N-(5-methylnicotinoyl)-4-hydroxypiperidine of Formula I, as shown in the accompanied drawings. This compound is a key intermediate for the synthesis of rupatadine, a potent dual antagonist of histamine and platelet-activating factor (PAF).

专利号:US-6909010-B2
优先权日:2001-04-11
标题:Facile synthesis of symmetric esters of alkylenebisphosphonic acids
发明人：HERLINGER ALBERT W; STEPINSKI DOMINIQUE C
权利人:UNIV LOYOLA CHICAGO
摘要:A facile synthesis of symmetric esters of C 1 -C 10 alkylenebisphopsphonic acids is disclosed in which a C 1 -C 10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazole and a base in an aprotic solvent to form a first reaction mixture. The first reaction mixture is maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(chloro ester phosphonate) that is reacted under basic conditions with an excess of a hydroxylated compound to form a second reaction mixture that is itself maintained for a time period sufficient to form a C 1 -C 10 alkylenebis(ester phosphonate) partial ester, homoleptic tetraester or mixed tetraester. The material so formed can be recovered or used as is.

专利号:US-6642376-B2
优先权日:2001-04-30
标 题 :Rational synthesis of heteroleptic lanthanide sandwich coordination complexes
发明人：LINDSEY JONATHAN S; GROSS THORALF
权利人:UNIV NORTH CAROLINA STATE
摘要:A half-sandwich coordination complex, useful for the synthesis of triple-decker sandwich coordination compounds, is produced by reacting a precursor complex of the formula XM(R 1 ) 2 wherein X is a halogen, M is a metal, and R 1 is an amide, with a free base porphyrinic macrocycle to produce said half-sandwich complex. The half-sandwich coordination complex can be used to make a triple-decker sandwich coordination compound by reacting a half-sandwich coordination complex as described above with a double-decker sandwich coordination compound.