CAS: 50529-33-4; 2-Chloro-1-Fluoro-4-Isocyanatobenzene

上下游产品

3-chloro-4-fluorophenylamine bis(trichloromethyl) carbonate phosgene 3-(3-chloro-4-fluoro-phenyl)-6-methyl-[1,3]oxazine-2,4-dione 1,1-Dibutyl-3-(3-chloro-4-fluoro-phenyl)-urea

📜3-氯-4-氟苯胺置于硫酸体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,反应生成 异氰酸-3-氯-4-氟苯酯
参考文献:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
标题:Organosilicon Synthesis Of Isocyanates: I. Synthesis Of Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series
摘要:A Convenient Synthesis Of Known And Unknown Isocyanates Of The Furan,Thiophene,And Mono-And Polyfluorophenyl Series,Involving Silylation Of Starting Amines With Hexamethyldisilazane Or Chlorotrimethylsilane,Followed By Phosgenation Of The Resulting N-Silyl-Substituted Amines. An Unusual High-Temperature Rearrangement Of 3-(Methoxycarbonyl)-4,5-Dimethylthiophene-2-Yl Isocyanate Into Its 5-Ethyl Isomer. Ortho-Fluorine Substituent In Anilines Decreases The Yield Of Isocyanates,Whereas 2,3,5,6-Tetrafluorophenyl Isocyanate Exists For Only A Short Time As A 5% Toluene Solution.
DOI:10.1134/s1070363206010208

专利信息

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-4644010-A
优先权日:1982-09-28
标题:Certain β-oxo-α-carbamoylpyrrolepropionitriles
发明人：WALKER GORDON N
权利人:CIBA GEIGY CORP
摘要:1-Unsubstituted β-oxo-α-(phenylcarbamoyl)-β-pyrrolylpropionitriles, e.g. those of the formula ##STR1## wherein R 1 and R 2 =H or alkyl, and R 3 and R 4 =H, alkyl, alkoxy, OH, halogen or CF 3 , are analgesic, and antiarthritic agents. Their synthesis, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds are included.