CAS: 433-53-4; Methyl Difluoroacetate

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CAS号67-56-1 甲醇 | CAS号2925-22-6 2,2-difluoroace... | CAS号425-88-7 1,1,2,2-四氟乙基甲醚 | CAS号116-54-1 二氯乙酸甲酯 | CAS号107-31-3 甲酸甲酯 | CAS号3832-48-2 溴二氟乙酰氯 | CAS号104-53-0 3-苯丙醛 | CAS号109872-87-9 methyl 2,2-difl... | CAS号381-73-7 二氟乙酸 | CAS号359-13-7 2,2-二氟乙醇 | CAS号129660-32-8 difluoroacetald... | CAS号41739-23-5 2,4 -戊二酮,1,1二氟 | CAS号352-24-9 二氟乙酰乙酸乙酯 | CAS号62679-61-2 4,4-二氟-1-苯基-1,3-丁二酮 | CAS号705-09-9 2-二氟甲基-1H-苯并咪唑 | CAS号1261289-79-5 4,4-Difluoro-3-... | CAS号41739-24-6 1,1-difluoro-5,...

二氯乙酸甲酯置于氢氟酸,三乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以98 %的收率获得产物二氟乙酸甲酯
参考文献:一种氟代乙酸酯的合成方法
标题:一种氟代乙酸酯的合成方法
摘要:本发明公开了一种氟代乙酸酯的合成方法,属于有机合成技术领域,将氯代乙酸酯与溶剂s1加入至反应釜中,并将反应釜加热至反应温度;将催化剂,溶剂s2加入到无水氟化氢中,控制温度,获得氟代溶剂;氟代溶剂加入至反应釜中,通过控制氟代溶剂的加入速度限定反应温度,获得反应液,过滤,滤液经减压精馏获得氟代乙酸酯.本发明反应过程为均相反应,氟代效率较氟化钾方式的固液反应有明显提高,且温度明显降低,同时反应周期大大缩短,氟元素利用率高,氟源过量比小于20%,催化剂的回收率可达97%及以上,方法简单,合成效率高,三废产生少,更加适合工业化生产.

专利信息

专利号:US-11370736-B2
优先权日:2019-04-01
标 题:Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
发明人：DUB PAVEL A; BATRICE RAMI J; GORDON JOHN C
权利人:TRIAD NAT SECURITY LLC
摘要:This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

专利号:US-9695208-B2
优先权日:2010-06-09
标 题:Sialic acid (A-(2-6))-D-aminopyranose derivatives, synthesis methods and uses thereof
发明人：YE XINSHAN; YANG FAN; ZHENG XIUJING
权利人:YE XINSHAN; YANG FAN; ZHENG XIUJING; UNIV BEIJING
摘要:N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.

专利号:US-12145139-B2
优先权日:2016-02-09
标题 :Manganese based complexes and uses thereof for homogeneous catalysis
发明人：MILSTEIN DAVID; NERUSH ALEX; VOGT MATTHIAS; MUKHERJEE ARUP; ESPINOSA-JALAPA NOEL ANGEL; CHAKRABORTY SUBRATA
权利人:YEDA RES & DEV; NERUSH ARKADI
摘要:The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

专利号:US-8735005-B2
优先权日:2010-04-02
标题 :Fluorinated cyclic carbonates and compositions thereof
发明人：HOLSTEIN WILLIAM L; CHEN XUDONG
权利人:HOLSTEIN WILLIAM L; CHEN XUDONG; DU PONT
摘要:Novel fluorinated cyclic carbonate compounds are described. These compounds may be useful as non-aqueous electrolyte solvents, specialty solvents, and starting materials and intermediates for synthesis of dyes, agricultural chemicals, and pharmaceuticals.

专利号:RU-2125995-C1
优先权日:1993-10-19
标题:Method of synthesis of asymmetrically substituted triazines

专利号:CN-107382742-A
优先权日:2017-07-30
标题:A new method for the synthesis of aromatic trifluoromethyl-containing intermediate 5-chloro-2-fluoro-4-(trifluoromethyl)aniline hydrochloride