CAS: 42474-44-2; 2,3,5-Trithiahexane

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CAS号624-92-0 二甲基二硫醚 | CAS号38634-59-2 (Methylthio)met... | CAS号85544-38-3 methylsulfanyl-... | CAS号5188-07-8 甲硫醇钠 | CAS号42474-27-1 2,3,5-trithiahe... | CAS号74-93-1 甲硫醇 | CAS号2229-07-4 methyl | CAS号34557-54-5 methane | CAS号74-86-2 乙炔 | CAS号80641-42-5 (methyldithio)m...

2,3,5-Trithiahexane 5-Oxide置于triethyloxonium Fluoroborate,Sodium Hydrogensulfite体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 2,3,5-三硫杂己烷
参考文献:Chemistry Of Alkyl Thiosulfinate Esters. Vii. Mechanistic Studies And Synthetic Applications
标题:Chemistry Of Alkyl Thiosulfinate Esters. Vii. Mechanistic Studies And Synthetic Applications
摘要:
DOI:10.1021/ja00819A034

专利信息

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.