CAS: 4117-31-1; (S)-Ethyl 2-Amino-3-Hydroxypropanoate

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26348-61-8 51537-21-4 60022-62-0

上下游产品

L-serin orthoformic acid triethyl ester ethanol L-serine ethyl ester hydr°Chloride2-Methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid ethyl ester (S)-2-(4-Chloro-phenyl)-oxazolidine-4-carboxylic acid ethyl ester (S)-2-(4-Nitro-phenyl)-oxazolidine-4-carboxylic acid ethyl ester (S)-2-Phenyl-oxazolidine-4-carboxylic acid ethyl ester

📜L-丝氨酸乙酯盐酸盐置于amberlyst A21 Resin体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.0H,以56%的收率获得产物丝氨酸乙酯
参考文献:使用连续流动系统的氨基酸酯与环己酮的立体保留 N-芳基化
标题:使用连续流动系统的氨基酸酯与环己酮的立体保留 N-芳基化
摘要:由于α-立体中心的敏感性,具有最小外消旋化的手性氨基酸酯的n-芳基化是具有挑战性的转化.开发了一种通用的合成方法,以在连续流动条件下使用环己酮作为芳基来源制备n-芳基化氨基酸酯.设计的流动系统由盘管反应器和含有 Pd(Oh) 2 /c 催化剂的填充床反应器组成,有效地提供了所需的n-芳基化氨基酸,而没有显着的外消旋化,仅伴随少量易于去除的共聚反应.-产品(即,H 2O 和烷烃).该方法的效率和稳健性允许以非常高的产率和对映体纯度连续合成所需的产物,同时具有高时空产率(74.1 G L-1 H-1)和周转频率(5.9 H-1)至少持续3天.
DOI:10.1002/chem.202101439

专利信息

专利号:US-9643915-B2
优先权日:2013-03-15
标题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:US-5801247-A
优先权日:1997-01-23
标题 :Process for the enantioselective synthesis of hydroxypyrrolidines from amino acids and products thereof
发明人：DALTON DAVID R; HUANG YIFANG
权利人:UNIV TEMPLE
摘要:The present invention relates to processes for the enantioselective synthesis of hydroxypyrrolidines from amino acids. An amino methyl ester is used as the starting material. The ester is reacted with a benziminoethyl ether to produce an oxazoline or thiazoline. Specifically, L-serine methyl ester is used to produce 4-(carbomethoxy)-2-phenyl-.increment. 2 -oxazoline, and cysteine is used to produce the corresponding thiazoline. The oxazoline (or thiazoline) can be reduced to an aldehyde by treatment with a slight excess of DIBAL-H. The oxazoline is quenched with alcohol and reacted with (carbomethoxymethylene)triphenylphosphorane, to produce (S)-(+)-methyl (E)- and (S)-(-)-methyl (Z)-3-(4,5-dihydro-2-phenyl-4-oxazolyl)-2-propenoate. The double bond is hydroxylated to yield the diol esters. The resulting diol is then treated with aqueous acid to hydrolyze the oxazoline and recyclize to produce 3,4-dihydroxy-5-hydroxymethylpyrrolidone benzoate. This is treated with an excess of borane in tetrahydrofuran to yield (2-hydroxymethyl) 3,4-dihydroxypyrrolidine. The intermediate compounds are useful both in the present process and as final products themselves. The total yield of the mixture of isomers, as well as their ratio, can be varied.

专利号:US-2023183175-A1
优先权日:2020-03-16
标 题:Method for preparing intermediate for use in synthesis of florfenicol and compounds prepared thereby
发明人：LI WENSEN; ZHANG WENQI
权利人:HEADING NANJING PHARMTECHNOLOGIES CO LTD
摘要:The present invention provides a method for preparing an intermediate of florfenicol, comprising: reacting p-methylthiobenzaldehyde with isocyanoacetate under catalysis of a chiral catalyst. In the reaction, the chiral product is oxidized to form a methylsulfone-substituted product which is subsequently deformylized to obtain the intermediate. In the method of the present invention, the chiral center of the intermediate is directly generated in the first step of reaction, and the yield of the first step reaches 75%-80%, which is significantly higher than the conventional chiral resolution methods (about 40% yield), and the product has high chiral purity. The method of the present invention does not use anhydrous copper sulfate that pollutes the environment, which reduces the environmental pressure. The compound of p-methylthiobenzaldehyde and the compound of isocyanoacetate are used to react to form a chiral intermediate, which has higher material availability and efficiency than linear synthesis methods.

专利号:US-4876323-A
优先权日:1984-02-27
标题:α-substituted acrylic acid esters, their polymers and method of synthesizing same
发明人：ENGEL JAMES F; BYERLEY THOMAS J; CHRISTIE HOWARD W
权利人:MIDWEST RESEARCH INST
摘要:α-Substituted acrylic acid esters, their polymers and adhesives therefrom, and methods of synthesizing these compounds. The compounds of the invention are useful as intermediates in the synthesis of isocyanato esters and can be polymerized to form an effective, non-toxic adhesive. The method of the invention encompasses utilizing the adhesive composition in biomedical applications, such as joining live animal tissue. Other adhesive applications are contemplated for living tissue and inanimate objects. The compounds are also used as monomers which can be polymerized, used in conjunction with other monomers as adhesive compositions, cross-linking agents, dye acceptor additives to vinylic polymers and useful chemical intermediates. The method of the invention encompasses synthesizing the aforementioned monomers and intermediates. Methyl α-(ethoxycarbonamido)acrylate is synthesized from either DL-serine or methyl pyruvate. For use as an intermediate, silyl substitution of the compound is accomplished by reacting the ester with trimethylchlorosilane. This α-substituted silated ester is used as an intermediate in the preparation of methyl α-isocyanatoacrylate, which can be polymerized with N-vinyl-2-pyrrolidone to produce a desirable adhesive. Analagous procedures, starting with L-ethyl serine and L-benzyl serine, respectively, are followed to arrive at the corresponding ethyl and benzyl esters.

专利号:US-2009149657-A1
优先权日:2005-11-09
标 题:Process for the synthesis of intermediates of chloramphenicol or its analogues