CAS: 38771-21-0; 4-Bromo-1-Butyne

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CAS号927-74-2 3-丁炔-1-醇 | CAS号23418-85-1 对甲苯磺酸3-丁炔酯 | CAS号10575-06-1 but-3-ynylsulfa... | CAS号51049-14-0 6,8-二甲氧基-4-甲基喹啉水合物 | CAS号5162-44-7 4-溴-1-丁烯 | CAS号19596-07-7 4-氰基-1-丁炔 | CAS号92144-00-8 1-iodo-2-methyl... | CAS号942518-21-0 N-芴甲氧羰基-L-炔丙基丙氨酸 | CAS号43001-25-8 4-碘-1-丁炔

3-丁炔-1-醇置于phosphorus Tribromide体系中,用27%的收率获得产物4-溴-1-丁炔
参考文献: Hybrid Necroptosis Inhibitors[fr] Inhibiteurs Hybrides De La Nécroptose
标题: Hybrid Necroptosis Inhibitors[fr] Inhibiteurs Hybrides De La Nécroptose
摘要:本发明涉及杂环化合物(例如,由式(i)描述的化合物)及其药学上可接受的盐.该发明还涉及包括这些化合物的药物组合物,以及它们在治疗可能出现大量坏死相关凋亡的疾病中的用途.本文描述的杂环化合物还可以实现对rip1和/或rip3的改进活性和选择性.

专利信息

专利号:US-6603070-B2
优先权日:2000-07-21
标题 :Convergent synthesis of multiporphyrin light-harvesting rods
发明人：LINDSEY JONATHAN S; LOEWE ROBERT S
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention provides a convergent method for the synthesis of light harvesting rods. The rods are oligomers of the formula A 1 (A b+1 ) b , wherein b is at least 1, A 1 through A b+1 are covalently coupled rod segments, and each rod segment A 1 through A 1+b comprises a compound of the formula X 1 (X m+1 ) m wherein m is at least 1 and X 1 through X m+1 are covalently coupled porphyrinic macrocycles. Light harvesting arrays and solar cells containing such light harvesting rods are also described, along with intermediates useful in such methods and rods produced by such methods.

专利号:US-9879043-B1
优先权日:2013-06-06
标 题:Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase
发明人：THORSON JON; HUBER TYLER; ZHANG JIANJUN; Singh Shanteri
权利人:UNIV KENTUCKY RES FOUND
摘要:The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: n nwhere X is S or Se, and R 1 is an alkyl group.

专利号:WO-2024186075-A1
优先权日:2023-03-03
标题 :Synthesis method of antibody-drug conjugates using proximity effect-based site-selective antibody labeling
发明人：LEE HYUN SOO; KIM SOOIN; KWEON YONGSEOK
权利人:UNIV SOGANG RES & BUSINESS DEVELOPMENT FOUND; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIV
摘要:The present invention relates to a method for the synthesis of an antibody-drug conjugate using proximity effect-based site-selective antibody labeling. Provided according to the present invention may be a method for the synthesis of an antibody-drug conjugate by site-selectively introducing a drug into an antibody using a pyridinium oxime derivative (labeling mediator protein) introduced into a binding protein containing a non-standard amino acid.

专利号:US-10047065-B2
优先权日:2014-12-17
标 题 :Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of gold(I) complexes
发明人：LETINOIS ULLA; NETSCHER THOMAS
权利人:DSM IP ASSETS BV
摘要:The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.

专利号:WO-2023092715-A1
优先权日:2021-11-23
标 题:Alanine aggregation-induced emission fluorescent probe, and synthesis method therefor and use thereof
发明人：ZHANG PENGFEI; CHEN GUANGRUI; Xiang Chunbai; LUO YUAN; CAI LINTAO
权利人:SHENZHEN INST ADV TECH
摘要:Provided are an alanine aggregation-induced emission fluorescent probe (TPAPy-D-Ala) having a structure as represented by formula (I), and a synthesis method therefor and the use thereof. The synthesis method for TPAPy-D-Ala comprises: firstly, synthesizing a first compound (TPAPy) as represented by formula (II); synthesizing a second compound (TPAPy-Butyne) as represented by formula (III) on the basis of the first compound; and finally, obtaining the TPAPy-D-Ala as represented by formula (I) on the basis of the second compound. A strategy for directly labeling a target with a fluorophore-D-amino acid is provided, wherein an amino acid is directly coupled with a fluorescent molecule, and participation in the metabolism of the target can be realized via the amino acid. Compared with bio-orthogonal labeling, this strategy can shun two-step operation and a complex catalyst required for a reaction, and achieve one-step direct labeling of a target.

专利号:US-9115172-B2
优先权日:2007-01-11
标 题 :Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
发明人：D SOUZA CHRISTOPHER A; MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of 18 F- or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may then be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the bifunctional chelating agent bound to 18 F- or 19 F-metal complex may be conjugated to the molecule to be labeled at a reduced temperature, e.g. room temperature.