CAS: 352439-36-2; Azide-Peg8-Alcohol

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Tetraethylene glycol 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl methanesulfonate 3,6,9,12,15,18,21,24-°Ctaoxaheptacos-26-yn-1-amine N-(2,4-dinitrophenyl)-3,6,9,12,15,18,21,24-°Ctaoxaheptacos-26-yn-1-amine (S)-2-(3-((S)-1-carboxy-5-(4-(25-(2,4-dinitrophenylamino)-2,5,8,11,14,17,20,23-°Ctaoxapentacosyl)-1H-1,2,3-triazol-1-yl)pentyl)ureido)pentanedioic acid

📜羟基-八聚乙二醇-对甲苯磺酸酯置于sodium Azide体系中,用 乙腈 作为反应溶剂,化学反应 22.0H,以90%的收率获得产物o-(2-叠氮乙基)七聚乙二醇
参考文献:一种超分子化合物纳米载体及其制备方法和应用
标题:一种超分子化合物纳米载体及其制备方法和应用
摘要:本发明公开了一种超分子化合物纳米载体及其制备方法和应用,涉及高分子化学与生物检测工程技术领域.本发明的超分子化合物纳米载体以阴离子诱导作用驱动自组装产生的二维纳米片超分子结构体系,超分子化合物纳米载体呈现由高度定向的一维纳米棒构建而成的单层纳米片超分子结构,疏水苝基部分作为构建高度定向的一维纳米棒的骨架部分,可调控单层纳米片的电荷密度;水溶性多价亲水部分表面可通过静电相互作用负载对重金属离子特异性检测的dnazyme脱氧核酶,构建水溶性多价超分子化合物纳米传感器,基于重金属离子的特异性切割所引起荧光变化机理,实现其在食品和生物组织中重金属离子的荧光检测,极大地增强了重金属离子检测效果.

专利信息

专利号:WO-2024119509-A1
优先权日:2022-12-09
标 题 :Synthesis method for second strand in dnb paired-end sequencing, sequencing method, and related products
发明人：XU CHONGJUN; JIANG LAN; YANG JIN; GONG MEIHUA
权利人:MGI TECH CO LTD
摘要:Provided are a synthesis method for a second strand in DNB paired-end sequencing, a sequencing method, and related products. The synthesis method for the second strand comprises: after DNB is subjected to first-strand sequencing, using a second-strand synthesis primer to synthesize the second strand, wherein the second-strand synthesis primer is a primer capable of being anchored on the surface of a sequencing chip. Using the second-strand synthesis primer that is anchored on the surface of a sequencing vector for the synthesis of the second strand makes the process of synthesizing the second strand relatively more stable. Moreover, the synthesized second-strand template is anchored on the sequencing vector, and subsequent sequencing of the second-strand template strand that is anchored on the sequencing vector can achieve a relatively higher quality of the second-strand sequencing.

专利号:US-12037641-B2
优先权日:2015-11-20
标题:Modified nucleotide reagents
发明人：SHEN GENE; YUE STEPHEN; SEBO LUBOMIR; BROGLEY LOUIS
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with high sensitivity at desirable wavelengths. They contain structural components that modulate the interactions of the analogs with DNA polymerase, thus decreasing photodamage and improving the kinetic and other properties of the analogs in sequencing reactions. Also provided are nucleotide and dye-labeled compounds of the subject analogs, as well as intermediates useful in the preparation of the compounds and analogs. Compositions comprising the compounds, methods of synthesis of the intermediates, compounds, and analogs, and mutant DNA polymerases are also provided.

专利号:US-9957291-B2
优先权日:2013-08-05
标题 :Protected fluorescent reagent compounds
发明人：SEBO LUBOMIR; HANES JEREMIAH; SHEN GENE; BROGLEY LOUIS; YUE STEPHEN; ZHENG FRANK; LAPIN YURI; LYLE JOHN; OSUNA HONEY; FEDOROV ANDREI
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The compounds contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements.

专利号:US-10787573-B2
优先权日:2015-02-04
标 题:Multimeric protected fluorescent reagents
发明人：ZHENG FRANK; HANES JEREMIAH; SHEN GENE; BROGLEY LOUIS; YUE STEPHEN; LAPIN YURI; LYLE JOHN; OSUNA HONEY; FEDOROV ANDREI; SEBO LUBOMIR
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC
摘要:Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.