专利号:US-8487108-B2 优先权日:2005-11-14 标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors 发明人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T 权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC 摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
专利号:US-4804679-A 优先权日:1984-07-24 标 题:Erythro-(E)-7-(3'-C1-3alkyl-1'-(3',5'-dimethylphenyl)naphth-2'-yl)-3,5-dihydroxyhept-6-enoic acids and derivatives thereof 发明人:ANDERSON PAUL L 权利人:SANDOZ PHARMACEUTICALS CORP 摘要:Compounds of the formula wherein R1 is C1-3alkyl, and Z is wherein R7 is hydrogen, R8 or M, wherein R8 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
专利号:CN-115028641-A 优先权日:2022-07-19 标题:A method for cobalt-catalyzed synthesis of 5,8-difunctional substituted imidazo[1,2-a]pyrazine compounds
专利号:US-5753675-A 优先权日:1989-03-03 标 题:Quinoline analogs of mevalonolactone and derivatives thereof 发明人:WATTANASIN SOMPONG 权利人:NOVARTIS PHARMACEUTICALS CORP 摘要:Quinoline analogs of mevalonolactone of the following formula are useful as anti-cholesterol synthesis agents: where the substituents are as defined in the specification.
专利号:US-4686237-A 优先权日:1984-07-24 标题 :Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3',5'-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof 发明人:ANDERSON PAUL L 权利人:SANDOZ PHARMACEUTICALS CORP 摘要:Compounds of the formula wherein R1 is C1-3alkyl, and Z is wherein R7 is hydrogen, R8 or M, wherein R8 is a physiologically acceptable and hydrolyzable ester group, and M is a pharmaceutically acceptable cation, the use thereof for inhibiting cholesterol biosynthesis and lowering the blood cholesterol level and, therefore, in the treatment of hyperlipoproteinemia and atherosclerosis, pharmaceutical compositions comprising such compounds and processes for and intermediates in the synthesis of such compounds.
专利号:US-11542346-B2 优先权日:2018-03-19 标 题 :Catalysts for olefin polymerization 发明人:IZMER VYATCHESLAV V; KONONOVICH DMITRY S; VOSKOBOYNIKOV ALEXANDER Z; VIRKKUNEN VILLE; RESCONI LUIGI MARIA CRISTOFORO 权利人:BOREALIS AG 摘要:New bisindenyl ligand complexes and catalysts comprising those complexes. The invention is directed to improving the manufacturing of specific C1-symmetric bisindenyl complexes by modifying one of the indenyl ligands in order to improve the selectivity of the complex synthesis towards the desired anti-isomer, increase the yield and simplify the purification of the complex. The invention also relates to the use of the new bisindenyl metallocene catalysts for the production of polypropylene homopolymers or propylene copolymers.