CAS: 30861-27-9; 7-Hydroxy-5-Methyl-2-(2-Oxopropyl)-8-((2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)-4H-Chromen-4-One

上下游产品

芦荟树脂a Aloeresin A 74545-79-2
2'-P-Methoxycoumaroylaloeresin

📜葡萄糖置于engineered Escherichia Coli Strain Bl21(De3) Harboring Rpals (Encoding Aloesone Synthase From Rheum Palmatum),Anti-Paba Synthetic Srna,Zwf (Encoding Glucose 6-Phosphate 1-Dehydrogenase From E. Coli),And Gtcgt[v93Q/y193F] (Encoding C-Glucosyltransferase[y93Q/y193F] From Gentiana Triflora)体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 芦荟苦素
参考文献:代谢工程大肠杆菌生产胭脂红酸
标题:代谢工程大肠杆菌生产胭脂红酸
摘要:胭脂红酸是一种在介壳虫(即指藻)中发现的芳香族聚酮化合物,是一种广泛使用的天然红色着色剂.长期以来,它是通过繁琐的昆虫养殖和多步纯化过程生产的.因此,人们对通过工程细菌发酵生产胭脂红酸产生了很大的兴趣.在这里,我们报道了工程大肠杆菌中葡萄糖完全生物合成胭脂红酸的过程.我们首先优化了发光杆菌 (Photorhabdus Luminescens) 的 Ii 型聚酮合酶机制,通过链霉菌(Streptomyces Sp) 环化酶 Zhui 和 Zhuj 的共表达,能够高水平生产黄酮酮酸. R1128.为了发现负责其余两个反应(羟基化和c-葡萄糖基化)的酶,通过测试报告执行类似反应的候选酶来进行生化反应分析.两种鉴定的酶,来自链霉菌的aklavinone 12-羟化酶(dnrf)和来自三花龙胆的c-葡萄糖基转移酶(gtcgt),分别可以成功地进行黄酮酸的羟基化和c-葡萄糖基化.然后,进行同源建模
DOI:10.1021/jacs.0C12406

专利信息

专利号:US-6083976-A
优先权日:1998-01-12
标 题 :Method of synthesis of derivatives of aloesin
发明人：PADMAPRIYA ABEYSINGHE; JONES KENNETH N
权利人:UNIVERA PHARM INC
摘要:The present invention discloses a method for the synthesis of derivatives of aloesin, alkylated at the C-7 hydroxyl group. The present invention includes the modified aloesins produced by the method of this invention and the use of these compounds as skin whitening agents.

专利号:US-6123959-A
优先权日:1998-04-24
标题:Aqueous composition comprising active ingredients for the de-pigmentation of the skin
发明人：JONES KENNETH; PADMAPRIYA ABEYSINGHE; TEICHMUELLER ERNST E; BLUME GABRIELE
权利人:UNIVERA PHARM INC; ROVI GMBH
摘要:The present invention discloses aqueous compositions comprising liposomes of phospholipids, and at least one competitive inhibitor of an enzyme for the synthesis of melanin, in combination with at least one non-competitive inhibitor of an enzyme for the synthesis of melanin. The invention also includes the use of the compositions of this invention for the de-pigmentation of skin.

专利号:US-12195435-B2
优先权日:2020-10-27
标题 :5-methylchromone and the preparation method and application thereof
发明人：LI YOUBIN; WANG XUESONG; WANG YAN; XU JUNYU; CHEN YU; ZENG TINGTING; Cui xue; Tan yinfeng; GONG JINGWEN
权利人:HAINAN MEDICAL UNIV
摘要:Disclosed is a 5-methylchromone and the preparation method and application thereof, the 5-methylchromone has the following structure:wherein R1 and R2 are alkyl groups. The substituted chromone has the biological activity of inhibiting tyrosinase. The preparation method uses 3,5-dihydroxytoluene as a raw material, and synthesis of chromones substituted with different groups at 2-C through acylation, esterification, rearrangement and cyclization reactions, etc. The 5-methylchromone is a completely new compound in condition that R1 is —CH2CH2CH3, and R2 is —CH2CH3, or that R1 is —C(CH3)3, and R2 is H. All the compounds have obvious inhibitory activity against tyrosinase, and can be used to prepare tyrosinase inhibitors or whitening agents.

专利号:WO-9934676-A1
优先权日:1998-01-12
标题:Method of synthesis of derivatives of aloesin

专利号:AU-2222499-A
优先权日:1998-01-12
标题:Method of synthesis of derivatives of aloesin

专利号:CN-115820676-A
优先权日:2022-09-14
标 题 :Application of Pa2643 gene in regulating and controlling yield of Pantoea agglomerans in synthesis of alopecurosporin A