CAS: 3031-95-6; N-[[5-Amino-1-(5-O-Phosphono-B-D-Ribofuranosyl)-1H-Imidazol-4-Yl]Carbonyl]-L-Aspartic Acid

上下游产品

阿卡地新 Aica Riboside 2627-69-2
羧基氨基咪唑核苷酸 5-Amino-4-Carboxylic Acid-1H-Imidazol-1-Yl Ribotide 6001-14-5
5-Amino-1-((3Ar,4R,6R,6Ar)-6-Hydroxymethyl-2,2-Dimethyl-Tetrahydro-Furo[3,4-D][1,3]Dioxol-4-yl)-1H-Imidazole-4-Carboxylic Acid Amide 3676-69-5
2’,3’,5’-三乙酰肌苷 2',3',5'-Tri-O-Acetylinosine 3181-38-2
9-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)-1-((2-Methoxyethoxy)Methyl)-1,9-Dihydro-6H-Purin-6-One 659746-61-9
肌苷 Inosine 58-63-9

📜2',3',5'-Tri-O-Acetyl-1-[(2-Methoxyethoxy)Methyl]Inosine置于盐酸,高氯酸,10 Wt% Pd(Oh)2 On Carbon,氨,水,氢气,Sodium Hydride,N,N-二异丙基乙胺,N-[(Dimethylamino)-3-Oxo-1H-1,2,3-Triazolo[4,5-B]Pyridin-1-Yl-Methylene]-N-Methylmethanaminium Hexafluorophosphate,Sodium Hydroxide体系中,用 四氢呋喃,甲醇,氯仿,水 用作溶剂,化学反应 22.83H,反应生成(2S)-2-[[5-氨基-1-[(2R,3R,4S,5R)-3,4-二羟基-5-(膦酰氧基甲基)四氢呋喃-2-基]咪唑-4-羰基]氨基]丁二酸
参考文献:一种合成saicar的方法
标题:一种合成saicar的方法
摘要:本发明一种合成saicar的方法,以5‑氨基‑1‑((2R,3R,4S,5R)‑3,4‑二羟基‑5‑(羟甲基)四氢呋喃‑2‑基)‑1H‑咪唑‑4‑甲酰胺为原料,依次经5‑氨基‑1‑((3Ar,4R,6R,6Ar)‑6‑(羟甲基)‑2,2‑二甲基四氢呋喃[3,4‑d][1,3]二氧‑4‑基)‑1H‑咪唑‑4‑甲酰胺,5‑氨基‑1‑((3Ar,4R,6R,6Ar)‑6‑(羟甲基)‑2,2‑二甲基四氢呋喃[3,4‑d][1,3]二氧‑4‑基)‑1H‑咪唑‑4‑羧酸,二苄基(5‑氨基‑1‑((3Ar,4R,6R,6Ar)‑6‑(羟甲基)‑2,2‑二甲基四氢呋喃[3,4‑d][1,3]二氧‑4‑基)‑1H‑咪唑‑4‑羰基)‑l‑天冬氨酸等的制备,制得成品纯度高达99.6%,杂质0.4%,非对映体过量(de)值为97.3%,收率16.9%.

专利信息

专利号:WO-2018192318-A1
优先权日:2017-04-20
标 题:Application of compounds interfering with saicar synthetase activity
发明人：ZHU WEI; PAN WUGUANG
权利人:GENEHEAL BIOTECHNOLOGY CO LTD
摘要:An application of compounds interfering with SAICAR synthetase activity. Based on existing protein structure data and small molecular data, screening is performed by means of software-based computational analysis to obtain compounds that can effectively interfere with PAICS activity. After the compounds are used, the synthesis of SAICAR can be reduced, so that the purpose of treating or mitigating tumors is achieved. By using at least two of the compounds in combination, it is likely to achieve a better effect of treating or mitigating tumors.

专利号:US-2022089775-A1
优先权日:2019-05-31
标题:Multiply auxotrophic cell line for the production of recombinant proteins and methods thereof
发明人：CHASIN LAWRENCE; ZHANG QINGHAO; DU ZHIMEI
权利人:UNIV COLUMBIA; MERCK SHARP & DOHME
摘要:The present invention provides, inter alia, a multiply auxotrophic cell line that is deficient in genes encoding enzymes that catalyze steps in the de novo synthesis of the pyrimidine and purine pathways, such as, e.g., uridine monophosphate synthetase (UMPS) and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC), respectively, for the production of recombinant proteins such as recombinant monoclonal and bispecific antibodies. Methods for preparing the multiply auxotrophic, in particular the doubly auxotrophic and octa-auxotrophic cell lines disclosed herein, methods for selecting a cell expressing a protein of interest, methods for producing a protein of interest, methods for optimizing the activity of a protein of interest, and kits for selecting a cell expressing a protein of interest, are also provided. In addition, recombinant proteins such as antibodies, including monoclonal and bispecific antibodies, made by the methods of the present disclosure are also provided.

专利号:US-2019298722-A1
优先权日:2016-08-10
标 题 :Use of an inhibitor of the de novo synthesis of purines, in the treatment of adenylosuccinate lyase deficiency

专利号:US-11517541-B2
优先权日:2017-04-20
标 题:Applications of spermidine and its derivatives
发明人：ZHU WEI; PAN WUGUANG
权利人:GENEHEAL BIOTECHNOLOGY CO LTD
摘要:Disclosed are applications of spermidine or its pharmaceutically acceptable derivatives. The inventors performed calculation and analysis using software based on existing data relating to protein and small-molecule structures, and screened out compounds which can effectively interfere with the activity of PAWS and thus reduce SAICAR synthesis, thereby achieving the goal of treating or improving tumors. It is expected to produce better effect in the treatment or improvement of tumors.

专利号:WO-2018029430-A1
优先权日:2016-08-10
标 题 :Use of an inhibitor of the de novo synthesis of purines, in the treatment of adenylosuccinate lyase deficiency

专利号:US-11766412-B2
优先权日:2016-09-29
标 题:Methods of treating or alleviating adenylosuccinatelyase (ADSL) deficiency using spermidine or a pharmaceutically acceptable salt of spermidine
发明人：PAN WUGUANG; ZHU WEI
权利人:GENEHEAL BIOTECHNOLOGY CO LTD
摘要:Provided are compounds reducing SAICAR accumulation, and applications. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or improving ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.