CAS: 290298-02-1;

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N-[(2E)-4-oxo-4-phenylbut-2-enoyl]-L-leucine N-[(2S)-2-(benzylamino)-4-oxo-4-phenylbutanoyl]-L-leucine L-leucine Benzoylacrylic acidL-leucine D-homophenylalanine N-[(2E)-4-(4-methoxyphenyl)-4-oxobut-2-enoyl]-L-leucine

📜N-[(2S)-2-(Benzylamino)-4-Oxo-4-Phenylbutanoyl]-L-Leucine 在 Palladium On Carbon,氢溴酸,氢气体系中,用 乙醇,水作为反应溶剂,40.0 °C,111.46 Kpa 条件下,反应 40.0H,以55%的收率获得n-[(2S)-2-Amino-4-Phenylbutanoyl]-L-Leucine
参考文献:Crystallisation-Induced Asymmetric Transformation (Ciat) For The Synthesis Of Dipeptides Containing Homophenylalanine
标题:Crystallisation-Induced Asymmetric Transformation (Ciat) For The Synthesis Of Dipeptides Containing Homophenylalanine
摘要:A Novel Synthesis Of Highly Enantioenriched Dipeptides Containing Homophenylalanine Is Described. The Process Involves A Crystallisation-Induced Asymmetric Transformation (Ciat) In A Michael Addition Followed By Exhaustive Reduction. A Unique Example Of A Formally Stereodivergent Ciat In Conjugate Addition Of An Achiral N-Nucleophile To Enantiomerically Pure Michael Acceptor Has Been Discovered. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/J.Tetasy.2010.11.015