CAS: 25705-52-6; (R)-2-Amino-2-Phenylacetic Acid Hydrochloride

上下游产品

(S)-2-azido-2-phenylacetic acid (3R,5S,6R)-2,3,5,6-Tetrahydro-3,5,6-triphenyl-1,4-oxazin-2-one 2,2-Dimethyl-propionic acid (2R,3R,4S,5S,6R)-2-({(R)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-phenylcarbamoyl]-phenyl-methyl}-formyl-amino)-4,5-bis-(2,2-dimethyl-propionyloxy)-6-(2,2-dimethyl-propionyloxymethyl)-tetrahydro-pyran-3-yl ester (R)-α-(N,N-dibenzylamino)-α-phenylacetic acid N-trichloroethoxycarbonyl-D-phenylglycine D-(-)-N-carbamoyl phenyl glycine

📜N-Boc-Glycine (-)-8-Phenylmenthol Ester置于n-溴代丁二酰亚胺(Nbs)体系中,用 四氯化碳 用作溶剂,化学反应生成D-(-)-苯甘氨酸酰氯盐酸盐
参考文献:N-Boc-α-氨基醇和α-氨基酸的立体选择性合成
标题:N-Boc-α-氨基醇和α-氨基酸的立体选择性合成
摘要:描述了n-Boc-α-氨基醇和α-氨基酸的立体选择性合成,向手性亲电甘氨酸当量α-溴-N-Boc-甘氨酸(-)苯基薄荷基酯中添加了格氏试剂.
Doi:10.1016/s0040-4039(00)80272-5

专利信息

专利号:US-3887606-A
优先权日:1971-06-02
标题 :Process for the preparation of DL-phenylglycine esters
发明人：PHILLIPPS GORDON HANLEY; STEPHENSON LESLIE; COOKSEY ALBERT ROY; CLARK JOHN COLIN
权利人:GLAXO LAB LTD
摘要:A process for the resolution of DL-phenylglycine esters in which said ester is treated with (+)-tartaric acid in the presence of a mixture of solvents of different polarities, one of which is an alkanol having 1-4 carbon atoms, and the (+)-hermitartrate of the D-phenylglycine ester is selectively crystallised therefrom. Dphenylglycine and/or its salts may be obtained by hydrolysis of the ester thus formed. D-phenylglycine is a valuable intermediate in the synthesis of antibiotics of the penicillin and cephalosporin types. The present invention provides a relatively cheap, high yield process for the production of optically active esters of phenylglycine by way of their diastereoisomeric salts and for the production of optically active phenylglycine therefrom. Novel D-phenylglycine esters and salts are disclosed.