CAS: 23239-36-3; Deterenol (Hydrochloride)

化学文摘社编号23232339-36-3,允许在化学数据库中精确识别,便利研究和监管合规;安全数据和处理预防措施,与任何化学物质一样,都应当与确保适当使用和尽量减少风险.

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合成工艺路线路线简述

  • 合成目标产物 Deterenol Hydrochloride 主要起始原料 1-(4-Hydroxyphenyl)-2-[(1-Methylethyl)Amino]Ethanone (Hydrochloride)
  • (文献来源)合成步骤主要原料 1-(4-Hydroxyphenyl)-2-[(1-Methylethyl)Amino]Ethanone (Hydrochloride)
📜1-(4-Hydroxy-Phenyl)-2-Isopropylamino-Ethanone; Hydrochloride置于sodium Tetrahydroborate,盐酸体系中,用 甲醇,水 用作溶剂,化学反应 2.0H,反应生成地特诺盐酸盐
参考文献:Synthesis And Uses Of Synephrine Derivatives
标题:Synthesis And Uses Of Synephrine Derivatives
摘要:本发明公开了一种新型合成橙皮碱,其衍生物和上述衍生物的盐,包括它们的中间体.橙皮碱的氮原子的一个或多个取代基被修改以产生衍生物.橙皮碱衍生物及其盐可用于治疗受β3-肾上腺素受体调节的动物的疾病,症状或紊乱.它们通常用作脂肪分解剂和/或减肥剂.

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专利信息


专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:US-2005250944-A1
优先权日:2004-05-04
标题:Synthesis and uses of synephrine derivatives

专利号:WO-2005108381-A1
优先权日:2004-05-04
标题 :Synthesis and uses of synephrine derivatives

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主要参考文献


1: Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine. Clin Toxicol (Phila). 2021 Nov;59(11):975-981. doi: 10.1080/15563650.2021.1894333. Epub 2021 Mar 23. Erratum in: Clin Toxicol (Phila). 2022 Jan 13;:1.
151:347-355. doi: 10.1016/j.jpba.2018.01.025. Epub 2018 Jan 31. 6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. 225(3):553-8. 67(3):443-52. doi: 10.1007/s13105-011-0078-2. Epub 2011 Feb 19. 85(21):7867-71. doi: 10.1073/pnas.85.21.7867.
7: Spearman TN, Durham JP, Butcher FR. The role of cyclic AMP in the regulation of exocytosis in the rat parotid gland: evidence obtained with the isoproterenol analog PI-39. J Cyclic Nucleotide Res. 1982;8(4):225-34.

合成参考文献


参考文献:10.1007/978-94-011-4439-1_4
摘要:Morton IKM, Hall JM. D. 1999. In: Concise Dictionary of Pharmacological Agents. : Springer Netherlands; 1999.
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