专利号:US-4895996-A 优先权日:1988-10-17 标 题 :Synthesis of alkenes from enamines via hydroboration 发明人:GORALSKI CHRISTIAN T; SINGARAM BAKTHAN; BROWN HERBERT C 权利人:PURDUE RESEARCH FOUNDATION; DOW CHEMICAL CO 摘要:Alkenes are prepared by the hydroboration of enamines followed by an elimination reaction to form the alkene. This process has wide applicability and is useful for the stereospecific synthesis of [Z] isomers. It is preferred to use 9-borabicyclo[3.3.1 nonane as the hydroborating agent and to use methanol to catalyze the elimination reaction.
专利号:US-2005004225-A1 优先权日:2003-04-16 标题:Oxidoreductase inhibitors and methods of screening and using thereof 发明人:BALENDIRAN GANESARATNAM K 摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:US-10647942-B2 优先权日:2016-12-22 标题:Fragrance and flavor materials 发明人:BLANDINO MAUREEN; LANKIN MICHAEL E 权利人:TAKASAGO PERFUMERY CO LTD 摘要:The present disclosure is directed to the synthesis and application of undecavertol derivatives having unique and desired flavor and/or fragrant characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.
专利号:US-2025091984-A1 优先权日:2022-04-07 标题:Fragrance and flavor materials 发明人:DICKERSON THALIA S; TURESKI ROBERT; BLANDINO MAUREEN 权利人:TAKASAGO PERFUMERY CO LTD 摘要:The present disclosure is directed to the synthesis and application of novel compounds having unique and desired flavor and/or fragrance characteristics. The compounds of the present disclosure can be employed alone or incorporated as fragrance or flavor compounds in fragrance or flavor compositions. The present disclosure is also directed to consumer products comprising such fragrance or flavor compounds and/or fragrance or flavor compositions.
专利号:US-12114681-B2 优先权日:2018-06-04 标题:Fragrance and flavor materials 发明人:BLANDINO MAUREEN; TANUMA KENJI 权利人:TAKASAGO PERFUMERY CO LTD 摘要:The synthesis and application of compounds having unique and desired flavor and/or fragrance characteristics are provided herein. The compounds herein can be employed alone or incorporated as fragrance or flavor ingredients in fragrance or flavor compositions. The application is also directed to consumer products comprising such derivatives and/or fragrance or flavor compositions.
参考标题:Synthesis Of (4E,6Z,10Z)-Hexadeca-4,6,10-Trien-1-Ol And (4E,6E,10Z)-Hexadeca-4,6,10-Trien-1-Ol, The Pheromone Components Of Cocoa Pod Borer Moth Conopomorpha Cramerella 作者:Fei Huang,Yushun Zhang,Yun Yao,Wanqiu Yang,Yunhai Tao 摘要:A Concise And Efficient Synthesis Of The Pheromone Components Of The Cocoa Pod Borer Moth, Namely (4E,6Z,10Z)-Hexadeca-4,6,10-Trien-1-Ol And (4E,6E,10Z)-Hexadeca-4,6,10-Trien-1-Ol, Starting From Commercially Available Materials, Was Reported. The Overall Yield Was 30.4% And 27.4%, Respectively. The Stereoselective Formation Of (E,Z)- Or (E,E)-Conjugated Double Bond Relied On Sonogashira Coupling With
合成参考文献
摘要:Hari, Y.; Aoyama, T.; Shioiri, T., Science of Synthesis Knowledge Updates, (2010) 4, 48. 摘要:Food and Chemical Toxicology., 20(663), 1982 摘要:Kirschning, A.; Gille, F.; Wolling, M., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 1, 393.