CAS: 18422-83-8; Dihydromorin

上下游产品

Trans-Dihydromorin

📜1-[2,4,6-三(甲氧基甲氧基)苯基]乙酮置于盐酸,双氧水,Potassium Hydroxide,Sodium Hydroxide体系中,用 甲醇,乙醇,正己烷,水 用作溶剂,化学反应 6.42H,反应生成2,3-Trans-Dihydromorin,二氢桑色素
参考文献:Stereospecific Inhibition Of Nitric Oxide Production In Macrophage Cells By Flavanonols: Synthesis And The Structure-activity Relationship
标题:Stereospecific Inhibition Of Nitric Oxide Production In Macrophage Cells By Flavanonols: Synthesis And The Structure-activity Relationship
摘要:To Explore The Structure-Activity Relationships On The Inhibitory Activity Of Flavanonols Against Nitric Oxide (No) Production In Inflammatory Cells,We Synthesized 19 Flavanonols Which Shared A Common 3,5,7-Trihydroxychroman Scaffold. A Range Of Substitutions Was Included In The B Ring In Order To Investigate The Structure-Activity Relationship. We Also Succeeded In Isolating Stereoisomers From 16 Of The Flavanonols Using Chiral Column Chromatography. The Inhibitory Effects Of These Compounds On No Production Were Examined In Raw 264.7 Cells (A Murine Macrophage-Like Cell Line),Which Were Activated By Lipopolysaccharide (Lps). We Only Observed Inhibitory Activity Against No Production In (2R,3R) Stereoisomers,While The Inhibitory Activities Of (2S,3S) Stereoisomers Were Significantly Weaker. We Also Evaluated The Free Radical Scavenging Potential Of The Flavanonols Using 1,1-Diphenyl-2-Picrylhydrazyl (Dpph). Each Stereoisomer Indicated The Equivalent Dpph Scavenging Potential As Expected. The Radical Scavenging Activity Was Not Correlated With The Inhibitory Activity Against No. The Inhibition Of No Production By Flavanonols Is Stereospecific And Cannot Simply Be Explained By Their Radical Scavenging Activity. We Propose The Possible Existence Of A 'Target' Molecule For Flavanonols Which Is Involved In The Production And/or Regulation Of No In Raw 264.7 Cells. (C) 2015 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2015.09.042