📜五氟化锑 反应生成氢六氟锑酸盐 参考文献:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: Sb: Mvol.B2,8.5,Page 405-408 标题:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: Sb: Mvol.B2,8.5,Page 405-408
专利信息
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-11629137-B2 优先权日:2017-04-24 标 题:Methods of manufacturing of niraparib 发明人:STEWART ALISTAIR; TOTO ANTHONY JOSEPH; CHEN FRANK XING; WU GEORGE 权利人:TESARO INC 摘要:Disclosed herein are methods and processes of preparing niraparib and pharmaceutically acceptable salts thereof, and intermediates and their salts useful for the synthesis of niraparib.
专利号:WO-0144184-A1 优先权日:1999-12-16 标题:Synthesis of indole-containing spla2 inhibitors 发明人:MARTINELLI MICHAEL JOHN; SAWYER JASON SCOTT 权利人:LILLY CO ELI; MARTINELLI MICHAEL JOHN; SAWYER JASON SCOTT 摘要:A method of making a compound include reacting a compound represented by formula (I), with a base, to form the compound of formula (II); and where R1 is H, R10 or -C(O)R10; R2 is R20 -OR20, -SR20, -NR20R20' or -C(O)R20;R3, R4, R5, R6 and R7 are each individually H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R or -S(O)2R; provided that at least one of R4 and R5 is not H; each R, R10 and R20 is individually alkyl, alkenyl, alkynyl, aryl or heterocyclic radical; each R' and R20' is individually H, alkyl, alkenyl, alkynyl, aryl or heterocyclic radical; and W is a trisubstituted phosphorous. The method provides an alternative route to indole-3-glyoxylamide compounds.
专利号:US-4218403-A 优先权日:1979-04-06 标 题 :Synthesis of aromatic aldehydes 发明人:VANDERPOOL STEVEN H 权利人:TEXACO DEVELOPMENT CORP 摘要:Covers a method for preparing a para-alkyl substituted phenyl aldehyde by reacting carbon monoxide and an alkyl mono-substituted benzene in presence of a tantalum, niobium or antimony pentafluoride-hydrogen fluoride catalyst.
专利号:WO-0144185-A1 优先权日:1999-12-16 标题 :Carbon monoxide-based synthesis of spla2 inhibitors 发明人:SAWYER JASON SCOTT 权利人:LILLY CO ELI; SAWYER JASON SCOTT 摘要:A method of making a compound, comprises reacting a compound represented by formula (I), with CO and a catalyst, to form the compound of formula (II); where formula (I) is and, formula (II) is and where R2 is selected from the group consisting of R20 -OR20, -SR20, -NR20R20'and -C(O)R20; R3, R4, R5, R6 and R7 are each individually selected from the group consisting of H, halogen, R, -OR, -SR, -NRR', -C(O)R, -C(O)OR, -S(O)R and -S(O)2R; provided that at least one of R4 and R5 is not H; each R and R20 is individually selected from the group consisting of alkyl, alkenyl, alkynyl, aryl and heterocyclic radical; and each R' and R20' is individually selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl and heterocyclic radical. The method provides an alternative route to indole-3-glyoxylamide compounds.
专利号:US-5399695-A 优先权日:1992-04-10 标 题:Method for the synthesis of quaternary ammonium salts 发明人:NAKANO SHINJI; MORIMOTO TAKAO; ENDO TAKESHI 权利人:NIPPON PAINT CO LTD 摘要:Provided is a convenient method for synthesizing quaternary ammonium salts which are useful as curing catalysts for one-part thermosetting resin compositions which maintain storage stability at room temperature. The ammonium salts are synthesized by direct reaction of a benzyl alcohol or a benzyl alkyl ether optionally having on the benzene ring and/or at α-position one or more substituent groups inert to the intended reaction, with a corresponding strong-acid salt of a tertiary amine.
[参考文献]: Rolf Minkwitz, Et Al. Halogenated Carboxonium Salts: Preparation And Structural Analysis. Inorg Chem. 1999 Mar 8;38(5):844-847.
合成参考文献
摘要:L808: ATSDR - Agency for Toxic Substances and Disease Registry (1990). Toxicological profile for silver. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp.asp id=539&tid=97