CAS: 158817-11-9; L-Tyrosine, O-[bis[2-(Methyldiphenylsilyl)Ethoxy]Phosphinyl]-N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-

该化合物是一种化学化合物,具有苯丙氧碳基(Fmoc)保护组,附于一个含有硫酸盐残留物的混合物,再用磷酸盐组进行进一步修改,该化合物主要用于浸泡合成和生物协同应用,因为它有能力保护氨基强硫素组,同时允许在其他功能场所有选择地作出反应;磷酸盐组的存在增强了其在各种溶剂中的再活性和溶解性,使之适合多种化学反应;MDPSE 运动表明,它含有一种特定的磷酸衍生物,能够促进生物分子或其他功能组的附加.

英文名称L-Tyrosine, O-[bis[2-(Methyldiphenylsilyl)Ethoxy]Phosphinyl]-N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-
中文名称N-[(9H-芴-9-基甲氧基)羰基]-O-[双[2-(甲基二苯基硅烷基)乙氧基]磷酰]-L-酪氨酸
IUPAC名称(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((bis(2-(methyldiphenylsilyl)ethoxy)phosphoryl)oxy)phenyl)propanoic acid
其它别名N-Alpha-(9-Fluorenylmethoxycarbonyl)-O-(Di-Diphenylmethylsilylethyl) Phosphno-L-Tyrosine; (Fmoc-Tyr(Po3(2-(Methyldiphenylsilyl)-Ethyl)2)-Oh); Fmoc-Tyr(Po3(Mdpse)2)-Oh; Fmoc-Tyrosine(Po3(Mdpse)2)-Oh; N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-O-[bis[2-(Methyldiphenylsilyl)Ethoxy]Phosphinyl]-L-Tyrosine; (2S)-3-[4-({bis[2-(Methyldiphenylsilyl)Ethoxy]Phosphoryl}Oxy)Phenyl]-2-({[(9H-Fluoren-9-yl)Methoxy]Carbonyl}Amino)Propanoic Acid; L-Tyrosine, O-[bis[2-(Methyldiphenylsilyl)Ethoxy]Phosphinyl]-N-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-; (2S)-3-[4-[bis[2-[methyl(Diphenyl)Silyl]Ethoxy]Phosphoryloxy]Phenyl]-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)Propanoicaci
CAS编号158817-11-9
MFCD编号:MFCD00798641
分子式:C54H54NO8PSi2分子量:932.17
产品CID: 793592
产品分类生物化工 → 氨基酸及其衍生物 → 酪氨酸类衍生物

相似结构搜索
InChIKey: ULCVFQDEKLBKAQ-MPLRIKRWSA-N
InChI=1S/C54H54NO8PSi2/c1-65(43-19-7-3-8-20-43,44-21-9-4-10-22-44)37-35-61-64(59,62-36-38-66(2,45-23-11-5-12-24-45)46-25-13-6-14-26-46)63-42-33-31-41(32-34-42)39-52(53(56
计算化学: 氢键受体数8.0氢键供体数2.0可旋转键数21.0

MSDS等安全信息

上下游产品

chloromethyldiphenylsilane N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide N-Fm°C-Tyr-OH L-tyrosine

合成工艺路线路线简述

📜Bis<2-(Methyldiphenylsilyl)Ethyl> N,N-Diisopropylphosphoramidite置于四氮唑,叔丁基过氧化氢,Potassium Hydrogensulfate体系中,用四氢呋喃用作溶剂,化学反应 5.0H,反应生成N-[(9H-芴-9-基甲氧基)羰基]-O-[双[2-(甲基二苯基硅烷基)乙氧基]磷酰]-L-酪氨酸
参考文献:Synthesis And Application Of Bis-Silylethyl-Derived Phosphate-Protected Fmoc-Phosphotyrosine Derivatives For Peptide Synthesis
标题:Synthesis And Application Of Bis-Silylethyl-Derived Phosphate-Protected Fmoc-Phosphotyrosine Derivatives For Peptide Synthesis
摘要:Three Fmoc-Phosphotyrosine Derivatives With Silylethyl-Based Phosphate Protection Were Synthesized And Evaluated For Use In Peptide Synthesis. The Stability Of These Derivatives Toward Piperidine/dmf (1:4) Treatment And Their Cleavability With Tfa Solutions Were Examined. On The Basis Of These Data,The Bis[(Methyldiphenylsilyl)Ethyl]-Protected Fmoc-Phosphotyrosine Derivative Or Fmoc-Tyr(Po(3)Mdpse(2))-Oh,Was Shown To Be The Most Suitable Candidate For The Production Of Phosphotyrosine Peptides. The Syntheses Of Phosphotyrosine Peptides Including One Containing Met And Cys Are Described.
Doi:10.1021/jo00101A029