CAS: 144222-34-4; N-((1R,2R)-2-Amino-1,2-Diphenylethyl)-4-Methylbenzenesulfonamide

上下游产品

CAS号35132-20-8 (1R,2R)-(+)-1,2... | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号192139-90-5 (S,S)-N-(对甲苯磺酰)...

N-[(1R,2R)-2-(Benzhydrylideneamino)-1,2-Diphenylethyl]-4-Methylbenzenesulfonamide置于盐酸体系中,用 四氢呋喃,水 用作溶剂,以93%的收率获得(1R,2R)-(-)-N-(对甲基苯磺酰基)-1,2-二苯基乙二胺
参考文献:芳香醛由芳香醛合成的芳香邻二胺.
标题:芳香醛由芳香醛合成的芳香邻二胺.
摘要:在本文中,描述了由醛和n-Ts亚胺的芳基邻位二胺的胺化胺合成.通过与2,2-二苯甘氨酸在甲醇中缩合,随后在thf中脱羧,将亲电子性芳族醛平稳地转化为离域的2-氮杂烯丙基阴离子,然后与n-Ts亚胺进一步反应,以高收率得到各种1,2-二胺衍生物.高顺/反非对映选择性.
Doi:10.1021/ol500522D

专利信息

专利号:US-2023278959-A1
优先权日:2020-05-04
标题:Synthesis of Optically Active Indoline Derivatives Via Ruthenium(II)-Catalyzed Enantioselective C-H Functionalization
发明人：CUI XIN; LI ZHONG-YUAN; CHAMINDA LAKMAL HETTI HANDI
权利人:UNIV MISSISSIPPI STATE
摘要:Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C—H bond and activating the unfunctionalized C—H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).

专利号:US-12240835-B2
优先权日:2018-09-18
标题:Substituted benzamides as intermediates in the synthesis of inhibitors of tyrosine kinase enzymatic activity
发明人：ROMERO F ANTHONY; KIRSCHBERG THORSTEN A; HALCOMB RANDALL; XU YINGZI
权利人:TERNS PHARMACEUTICALS INC
摘要:Provided herein are compounds, preferably compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, compositions thereof, and methods of their preparation, and methods of inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, and methods for treating diseases wherein modulation of BCR-ABL1 activity prevents, inhibits, or ameliorates the pathology and/or symptomology of the disease. Intermediates such as compounds of Formula (S23), which are useful in the synthesis of compounds inhibiting tyrosine kinase enzymatic activity of a protein selected from Abelson protein (ABL1), Abelson-related protein (ABL2), or a chimeric protein BCR-ABL1, are also provided.

专利号:US-12122759-B2
优先权日:2017-11-07
标 题:Method for the synthesis of cyclic depsipeptides
发明人：HEIMBACH DIRK; OMURA SATOSHI; SUNAZUKA TOSHIAKI; HIROSE TOMOYASU; NOGUCHI YOSHIHIKO; Köbberling Johannes; WU ZHIJIE; FU SHUIBIAO; WU WEI; QIU JINFENG; HE LIU; WEI XUDONG
权利人:ELANCO ANIMAL HEALTH GMBH; THE KITASATO INST
摘要:The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.

专利号:US-2016222024-A1
优先权日:2013-09-20
标 题:S-enantiomer of tetracyclic indole derivative as pbr ligands
发明人：TRIGG WILLIAM JOHN; JONES PAUL ALEXANDER
权利人:GE HEALTHCARE LTD
摘要:The present invention concerns in vivo imaging and in particular in vivo imaging of translocator protein (TSPO, formerly known as the peripheral benzodiazepine receptor). An indole-based in vivo imaging agent is provided that overcomes problems relating to known TSPO-binding radiotracers. The present invention also provides a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said precursor compound. Other aspects of the invention include a method for the synthesis of the in vivo imaging agent of the invention comprising use of the precursor compound of the invention, a kit for carrying out said method, and a cassette for carrying out an automated version of said method. In addition, the invention provides a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, as well as methods for the use of said in vivo imaging agent.

专利号:WO-2025058704-A1
优先权日:2023-09-15
标 题:Process for the preparation of epinephrine and norepinephrine
发明人：YUE TAI-YUEN; SAHANI RAJKUMAR; JAYARAMAN ARAVINDAN; DONSBACH KAI; SENANAYAKE CHRIS; QU BO; SIRASANI GOPAL; MANGUNURU HARI; JANGANATI VENUMADHAV; GANGU ARAVIND; TERRAB LEILA; KALIKINIDI NAGESWARA
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:A method of preparing epinephrine or norepinephrine is provided. The method includes reacting a starting material comprising 2-chloro-l-(3,4-dihydroxyphenyl)ethan-l- one with an amine nucleophile RNH2 (R=H for the synthesis of epinephrine or Me for the synthesis of norepinephrine) under conditions suitable for nucleophilic substitution of the starting material to form a substituted starting material and reacting the substituted starting material with a tethered ligand transition metal catalyst under conditions suitable for transfer¬ hydrogenation to produce epinephrine or norepinephrine.

专利号:US-8242277-B2
优先权日:2006-12-12
标题:Preparation of tetrahydroisoquinolines from dihydroisoquinolines
发明人：CANTRELL GARY L; MAGPARANGALAN DAN P; MOSER FRANK W; BAO JIAN; GROTE CHRISTOPHER W; WANG PETER X
权利人:CANTRELL GARY L; MAGPARANGALAN DAN P; MOSER FRANK W; BAO JIAN; GROTE CHRISTOPHER W; WANG PETER X; MALLINCKRODT LLC
摘要:The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.