CAS: 139631-62-2; Cyclopropanesulfonylchloride

上下游产品

CAS号23719-80-4 环丙基溴化镁 | CAS号68846-57-1 二环丙基二硫 | CAS号1083326-19-5 N-(5-溴吡啶-3-基)环丙烷磺酰胺 | CAS号1083326-05-9 N-(5-溴-2-甲氧基-3-... | CAS号146475-51-6 环丙基磺酸异丙酯 | CAS号146475-53-8 N,N-二乙基环丙烷磺酰胺 | CAS号21297-68-7 环丙烷磺酸 | CAS号83635-12-5 环丙磺酸丁酯 | CAS号1019855-82-3 N-(4-硝基苄基)环丙烷磺酰胺 | CAS号154350-29-5 环丙磺酰胺

Cyclopropanesulfonohydrazide置于n-氯代丁二酰亚胺体系中,用 乙腈 用作溶剂,化学反应 2.0H,以62%的收率获得环丙磺酰氯
参考文献:从磺酰肼轻松合成磺酰氯/溴化物
标题:从磺酰肼轻松合成磺酰氯/溴化物
摘要:描述了一种使用 Nxs(x = Cl 或 Br)从磺酰肼高效合成磺酰氯/溴化物并在后期转化为几个其他官能团的简单快速方法.多种亲核试剂可以参与这种转化,从而可以合成复杂的磺酰胺和磺酸盐.在大多数情况下,这些反应具有高度选择性,简单且清洁,以优异的收率提供产品.
Doi:10.3390/molecules26185551

专利信息

专利号:US-7728135-B2
优先权日:2005-01-06
标 题:Synthesis of CCR5 receptor antagonists
发明人：SHI XIONGWEI; ZHU MAN; LEONG WILLIAM; DAHANUKAR VILAS; ZAVIALOV ILIA A; PROIETTI CECELIA; ZHAO SHANNON; LEE HONG-CHANG; LIU YI; NGUYEN HOA N; WU WENXUE; D SA BOSCO; LIANG FENG; TRAN LOC THANH
权利人:SCHERING CORP
摘要:The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.

专利号:US-9394264-B2
优先权日:2009-11-13
标 题:Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA
权利人:RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:WO-2023083247-A1
优先权日:2021-11-11
标 题:Intermediate compound of quinoxaline and preparation process thereof
发明人：LIU JIE
权利人:4B TECH SUZHOU LIMITED; 4B TECH BEIJING CO LTD
摘要:Disclosed are an intermediate compound of quinoxaline of formula A, the use in the preparation of intermediates and bulk medicines thereof, and a synthesis method. The method avoids cumbersome separation and purification steps, reduces costs, improves reaction yield, avoids the use of POCl3 in the prior art, avoids the generation of a large amount of harmful wastewater,and is more suitable for industrial production.

专利号:CN-101137646-A
优先权日:2005-01-06
标题 :Synthesis of CCR5 Receptor Antagonist