专利号:US-2025281509-A1 优先权日:2021-04-26 标 题 :Sequential hormone therapy to improve survival and enhance response to immune therapy in men with prostate cancer 发明人:DENMEADE SAMUEL R; ISAACS JOHN T; ANTONARAKIS EMMANUEL S; KACHHAP SUSHANT; MARKOWSKI MARK CHRISTOPHER 权利人:UNIV JOHNS HOPKINS 摘要:Disclosed are methods for treating men with castrate resistant prostate cancer with a sufficient dose of testosterone to achieve supraphysiologic serum levels of testosterone in sequence with androgen ablative treatment or androgen synthesis inhibitors for one or more cycles until evidence of radiographic progression, at which point the subject will receive immune checkpoint blockade therapy.
专利号:US-4537722-A 优先权日:1983-05-30 标 题:Steroid esters preparation 发明人:STAMVIK ANDERS R; KRISTENSSON STEN K; LUNDVALL KARL-ERIK 权利人:LEO AB 摘要:This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in high yields.
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664 参考文献:10.1007/s11095-006-0072-5 摘要:Leichtnam M, Rolland H, Wüthrich P, Guy RH. Testosterone Hormone Replacement Therapy: State-of-the-Art and Emerging Technologies. Pharmaceutical Research. 2006 Jun 09;23(6):1117–32. doi: 10.1007/s11095-006-0072-5.