CAS: 1063-77-0; (1S,3As,4Ar,4Br,6Ar,11S,11Ar,11Br,13As)-1-(Furan-3-yl)-4B,7,7,11A,13A-Pentamethyl-3,5,9-Trioxohexadecahydrooxepino[4',3':3,4]Benzo[1,2-F]Oxireno[2,3-D]Isochromen-11-Yl Acetate
该化合物是一种自然形成的化合物,被归类为豪华轿车,主要见于柑橘水果,特别是种子和皮果,以其苦味著称,是展示各种生物活动的更多化合物的一部分;Nomilin对其潜在的健康惠益,包括防炎,抗氧化剂和抗癌特性,引起了兴趣;其结构具有碳环和功能组的复杂安排,有助于其独特的化学行为;除了生物意义外,Nomilin还因其杀虫特性而在食品保存和天然杀虫剂方面的潜在应用进行研究;然而,还需要进一步研究,以充分了解其行动和潜在治疗用途的机制;
- 英文名称(1S,3As,4Ar,4Br,6Ar,11S,11Ar,11Br,13As)-1-(Furan-3-yl)-4B,7,7,11A,13A-Pentamethyl-3,5,9-Trioxohexadecahydrooxepino[4',3':3,4]Benzo[1,2-F]Oxireno[2,3-D]Isochromen-11-Yl Acetate
- 中文名称诺米林
- IUPAC名称(1S,3aS,4aR,4bR,6aR,11S,11aR,11bR,13aS)-1-(furan-3-yl)-4b,7,7,11a,13a-pentamethyl-3,5,9-trioxohexadecahydrooxepino[4',3':3,4]benzo[1,2-f]oxireno[2,3-d]isochromen-11-yl acetate
- 其它别名1-(Acetyloxy)-1,2-dihydroobacunoic acid epislon-lactone
- CAS编号1063-77-0
- MFCD编号:MFCD00075979
- FDA UNII编号:DRM0753K4T
- 分子式:C28H34O9分子量:514.57
- 产品CID: 104036
- 产品分类生物化工
物理性质
MSDS等安全信息
合成工艺路线路线简述
专利信息
专利号:US-6166003-A
优先权日:1999-02-17
标 题 :Heterocyclic compounds for cancer chemoprevention
发明人：LAM LUKE K T
权利人:LKT LAB INC
摘要:A compound comprising a heterocyclic moiety, such as a thiophene, covalently attached to an alkylene isothiocyanate moiety. The compound is effective to prevent the occurrence or progression of cancer or a precancerous condition, and can be used for therapeutic or prophylactic purposes. The compound can be provided and administered in the form of a pharmaceutical composition, a cosmetic, a food additive, supplement, or the like. Methods for synthesis and use of the chemopreventive compound of the invention are also provided.
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主要参考文献
1: Ronningen I, Miller M, Xia Y, Peterson DG. Identification and validation of sensory-active compounds from data-driven research: A flavoromics approach. J Agric Food Chem. 2017 May 19. doi: 10.1021/acs.jafc.7b00093. [Epub ahead of print] pii: E4. doi: 10.3390/foods5010004.
3: Avula B, Sagi S, Wang YH, Wang M, Gafner S, Manthey JA, Khan IA. Liquid Chromatography-Electrospray Ionization Mass Spectrometry Analysis of Limonoids and Flavonoids in Seeds of Grapefruits, Other Citrus Species, and Dietary Supplements. Planta Med. 2016 Jul;82(11-12):1058-69. doi: 10.1055/s-0042-107598. Epub 2016 May 25. doi: 10.1080/15592324.2016.1183084.
5: Wang F, Yu X, Liu X, Shen W, Zhu S, Zhao X. Temporal and spatial variations on accumulation of nomilin and limonin in the pummelos. Plant Physiol Biochem. 2016 Sep;106:23-9. doi: 10.1016/j.plaphy.2016.04.039. Epub 2016 Apr 23. doi: 10.1016/j.foodchem.2015.11.113. Epub 2015 Nov 26. doi: 10.3390/s151229787.
合成参考文献
参考文献:10.1207/s15327914nc402_15
摘要:Tian Q, Miller EG, Ahmad H, Tang L, Patil BS. Differential inhibition of human cancer cell proliferation by citrus limonoids. Nutr Cancer. 2001;40(2):180–4. doi: 10.1207/s15327914nc402_15.
参考文献:10.1021/ac030115w
摘要:Tian Q, Schwartz SJ. Mass spectrometry and tandem mass spectrometry of citrus limonoids. Anal Chem. 2003 Oct 15;75(20):5451–60. doi: 10.1021/ac030115w.
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