CAS: 944401-77-8; 2-Amino-4-Fluoropyridine

• 英文名称2-Amino-4-Fluoropyridine
• 中文名称2-氨基-4-氟吡啶
• IUPAC名称4-fluoropyridin-2-amine
• 其它别名4-Fluoropyridin-2-amine
• CAS编号944401-77-8
• MFCD编号:MFCD09260906
• EINECS号:815-037-5
• 分子式:C5H5FN2
• 分子量:112.11
• 产品CID: 1994936
• 产品分类医药中间体 → 吡啶类化合物

• 相似结构搜索
• InChIKey: WCCFLOQQACDOAX-UHFFFAOYSA-N
• InChI=1S/C5H5FN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数0.0

物理性质

• 熔点102 °C
• 沸点211.5±20.0 °C at 760 mmHg
• 闪点81.7±21.8 °C
• 密度1.3±0.1 g/cm3
• pKa:6.42±0.11(预测)
• PSA:38.91
• LogP:0.97
• 折射率1.554
• 蒸汽压0.2±0.4 mmHg at 25°C
• 溶解性Slightly Soluble In Water.
• 外观形态淡黄色固体
• 储存条件请置于阴暗处, 惰性气氛中,2-8°C
• 产品应用该化合物是有机合成和药物中的一个重要中间体.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  急性毒性 类别4(经口)
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  严重眼损伤 类别1
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H302 |吞咽有害.
  H332 |吸入有害.
  H312 |皮肤接触有害.
  H318 |造成严重眼损伤.
• 防范说明P261-P280-P304+P340-P305+P351+P338-P405-P501a
• 危险等级IRRITANT
• 危险品标志Xi
• 安全声明H303+H313+H333

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 2-Amino-4-Fluoropyridine 主要起始原料 2-Amino-4-Chloropyridine
• 1172938-55-4 = 944401-77-8
  反应条件:1.1 Reagents: Sodium Hydroxide,Bromine Solvents: Water; 6 - 8 H,60 - 80 °C
  标题:Preparation Of 4-Fluoropyridin-2-Amine
  参考文献:China]
  
  14874-70-5 = 944401-77-8
  反应条件:1.1 Rt -> 120 °C; 120 °C
  标题:Synthetic Method Of 2-Amino-4-Fluoropyridine With High Yield
  参考文献:China]
  
  34941-91-8 = 944401-77-8
  反应条件:1.1 Reagents: Cesium Carbonate,Benzophenone Imine Catalysts: Tris(Dibenzylideneacetone)Dipalladium,1,1′-(9,9-Dimethyl-9H-Xanthene-4,5-Diyl)Bis[1,1-Diphenylphosphine] Solvents: Tetrahydrofuran; 4 H,Rt -> 65 °C; 65 °C -> 60 °C; Overnight,60 °C; 60 °C -> Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; 30 Min,Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Basified
  标题:Preparation Of Imidazopyridines As Inhibitors Of Igf-1R And Ir And One Or Both Of Egfr And Erbb2 Kinases For Treating Neoplasm
  参考文献:United States]
  
  1237535-76-0 = 944401-77-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; Cooled; Overnight,Rt
  标题:Imidazopyridine Derivatives As Modulators Of Tnf Activity And Their Preparation
  参考文献:World Intellectual Property Organization]
  
  1237535-76-0 = 944401-77-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 0 - 5 °C; 16 H,Rt
  标题:Preparation Of Substituted N-(1H-Indazol-4-Yl)Imidazo[1,2-A]Pyridine-3-Carboxamide Compounds As Type Iii Receptor Tyrosine Kinase Inhibitors
  参考文献:World Intellectual Property Organization]
  
  19798-80-2 = 944401-77-8
  反应条件:1.1 Reagents: Sodium Fluoride Solvents: Dimethylformamide; 5 - 8 H,140 °C
  标题:Preparation Method Of 2-Amino-4-Fluoropyridine
  参考文献:China]
  
  1172938-55-4 = 944401-77-8
  反应条件:1.1 Reagents: Sodium Hypochlorite Solvents: Water; Rt; Rt -> 80 °C
  标题:Method For Synthesizing 2-Amino-4-Fluoropyridine With Pyridine-2-Carboxylic Acid As Raw Material
  参考文献:China]
  
  19798-80-2 = 944401-77-8
  反应条件:1.1 Reagents: Potassium Fluoride Solvents: N-Methyl-2-Pyrrolidone; 10 H,Rt -> 200 °C
  标题:Synthesis Of 4-Fluoro-2-Aminopyridine
  作者:Zhao,Chunshen; Song,Wuyan; Wu,Changyun; Wu,Shengfu; Wang,Sidong
  参考文献:Guangdong Huagong 日期:2013 卷标:40(17)]
  
  1433204-32-0 = 944401-77-8
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Tetrahydrofuran,Water; Overnight,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 10
  标题:Heterocyclic Fused Pyridines And Related Compounds As Inhibitor Compounds Of Phosphodiesterase Type 10A And Their Preparation And Use In The Treatment Of Neurological And Psychiatric Disorders
  参考文献:United States]
  
  1237535-76-0 = 944401-77-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; Cooled; Overnight,Rt
  标题:Tetrahydroimidazopyridine Derivatives As Modulators Of Tnf Activity And Preparation
  参考文献:World Intellectual Property Organization]
  
  1237535-76-0 = 944401-77-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; Overnight,Rt
  标题:Preparation Of Indan Derivatives As Protein Kinase Inhibitors
  参考文献:China]
  
  1237535-76-0 = 944401-77-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 0 - 5 °C; 16 H,Rt
  标题:Preparation Of Substituted N-(1H-Indazol-4-Yl)Imidazo[1,2-A]Pyridine-3-Carboxamides As Cfms Inhibitors
  参考文献:World Intellectual Property Organization]
  
  = 944401-77-8 [标题:Reaction Conditions
  标题:Synthesis Of 2-Amino-4-Fluoropyridine-C-Nucleoside Phosphoramidite For Incorporation Into Oligonucleotides
  作者:Sato,Kousuke; Matsuda,Akira
  参考文献:Current Protocols In Nucleic Acid Chemistry 日期:2019 卷标:77(1)]
  
  = 944401-77-8 [标题:Reaction Conditions
  标题:Pyrimidine Derivatives Used As Pi-3 Kinase Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
  参考文献:World Intellectual Property Organization

海关参考信息

• 2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

专利信息

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