CAS: 9001-63-2; Lysozymes

• 英文名称Lysozymes
• 中文名称溶菌酶
• IUPAC名称L-arginyl-L-valyl-L-valyl-L-arginyl-L-aspartyl-L-prolyl-L-glutaminylglycyl-L-isoleucyl-L-arginyl-L-alanyl-L-tryptophyl-L-valyl-L-alanyl-L-tryptophyl-L-arginyl-L-asparaginyl-L-arginine
• 其它别名Lysosyme Chloride; Mucopeptide; Lysozyme From Chicken Egg White, Type Vi Molecular Biology Gr,3X Crystallized; Heneggwhite; N-Acetylmuramide Glycanohydrolase; Humanlysozyme; Egglysozyme
• CAS编号9001-63-2
• MFCD编号:MFCD00131557
• EINECS号:232-620-4
• 分子式:C99H159N37O23
• 分子量:2235.6
• 产品CID: 1930954
• 产品分类生物化工 → 酶及辅酶类药

• 相似结构搜索
• InChIKey: ZJCXKXFAOCLSRV-RYLVIXIQSA-N
• InChI=1S/C99H159N37O23/c1-11-50(8)77(132-72(139)46-120-81(145)63(32-33-70(101)137)124-88(152)69-31-21-39-136(69)93(157)68(43-73(140)141)131-…
• 计算化学: 氢键受体数29.0氢键供体数38.0可旋转键数75.0

物理性质

• 沸点632.7±55.0 °C at 760 mmHg
• 闪点336.4±31.5 °C
• 密度1.5±0.1 g/cm3
• PH:3.5 (20°C in H2O, Aqueous solution)
• PSA:1013.79
• LogP:-3.09
• 折射率1.689
• 溶解性Soluble In DMSO
• 敏感性Stable. Incompatible with strong oxidizing agents.
• 外观形态白色粉末
• 储存条件-20°C
• 产品应用主要用于五管科多种粘膜疾患,如副鼻窦炎,慢性鼻炎,咽喉炎,扁平苔癣,口腔溃疡,渗出性中耳炎等徉患,亦用于皮肤科带状包疹,扁平疣及铬性鼻炎. 产品说明书 溶菌酶(lysozyme)又称胞壁质酶(muramidase)或N-乙酰胞壁质聚糖水解酶(N-acetylmuramide glycanohydrlase),是一种能水解致病菌中黏多糖的碱性酶.主要通过破坏细胞壁中的N-乙酰胞壁酸和N-乙酰氨基葡糖之间的β-1,4糖苷键,使细胞壁不溶性黏多糖分解成可溶性糖肽,导致细胞壁破裂内容物逸出而使细菌溶
• 性质描述蛋白质溶菌酶是由129个氨基酸组成的均一链的多肽.为白色冷冻干粉或结晶.等电点为10.5-11.0.酸性溶液较为稳定,加热到55°C无影响,能溶于水.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08;
  注释: Health hazard
• 危险类别严重眼刺激 类别2
  呼吸道致敏 类别1
  皮肤致敏 类别1
• 警示词Danger(危险)
• 危险描述H319 |造成严重眼刺激.
  H334 |吸入可能引起过敏或哮喘症状或呼吸困难.
  H317 |可能引起皮肤过敏反应.
• 防范说明P261-P285-P304+P341-P342+P311-P501
• UN编号NONH for all modes of transport
• 危险品标志B,Xi
• 安全声明23-24/25-36/37/39-26
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

合成工艺路线路线简述

• 73731-37-0 + 71989-16-7 + 71989-28-1 + 105047-45-8 + 119062-05-4 + 29022-11-5 + 68858-20-8 + 71989-31-6 + 35661-39-3 + 73724-45-5 + 135248-89-4 + 71989-23-6 = 9001-63-2
  反应条件:1.1 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.2 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.3 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.4 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.5 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.6 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.7 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.8 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.9 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.10 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.11 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...1.12 Reagents: 1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi...
  标题:The Effect Of Peptide Glycation On Local Secondary Structure
  作者:Povey,Jane F.; Howard,Mark J.; Williamson,Richard A.; Smales,C. Mark
  参考文献:Journal Of Structural Biology 日期:2008 卷标:161(2) 页码:151-161]
  
  = 9001-63-2
  反应条件:1.1 Reagents: Water; Overnight,Ph 5.5,25 - 28 °C
  标题:Preparation Of Mal-Sac-Mpeg And Its Primary Modification To Lysozyme
  作者:Wu,Jie; Hu,Zhuoyi; Liu,Jingjing
  参考文献:Yaowu Shengwu Jishu 日期:2005 卷标:12(1) 页码:6-9]
  
  9001-63-2 = 9001-63-2
  反应条件:1.1 Catalysts: Hexamethyldisiloxane Solvents: Water,1-Butyl-3-Methylimidazolium Tetrafluoroborate; 24 H,Ph 7,37 °C
  标题:Hmdo-Promoted Peptide And Protein Synthesis In Ionic Liquids
  作者:Duan,Jianli; Sun,Yao; Chen,Hao; Qiu,Guofu; Zhou,Haibing; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2013 卷标:78(14) 页码:7013-7022]
  
  9001-63-2 + 120-74-1 = 9001-63-2
  反应条件:1.1 Reagents: N-Hydroxysuccinimide,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dimethylformamide; 15 Min,Rt1.2 Solvents: Water; 3 H,Ph 8.5,Rt1.3 Solvents: Dimethyl Sulfoxide; 1 Min1.4 Reagents: Sodium Dodecyl Sulfate Solvents: Water; Rt; 5 Min,95 °C
  标题:Synthesis Of Macrocyclic Tetrazoles For Rapid Photoinduced Bioorthogonal 1,3-Dipolar Cycloaddition Reactions
  作者:Yu,Zhipeng; Lim,Reyna K. V.; Lin,Qing
  参考文献:Chemistry - A European Journal 日期:2010 卷标:16(45) 页码:13325-13329]
  
  9001-63-2 = 9001-63-2
  反应条件:1.1 Solvents: Water1.2 Reagents: Sodium Hydroxide
  标题:Chemoenzymatic Synthesis Of Neoglycoproteins Using Transglycosylation With Endo-β-N-Acetylglucosaminidase A
  作者:Fujita,Kiyotaka; Takegawa,Kaoru
  参考文献:Biochemical And Biophysical Research Communications 日期:2001 卷标:282(3) 页码:678-682

海关参考信息

• 2902200000-苯
  2905121000-正丙醇
  2905130000-正丁醇
  2912110000-甲醛
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