CAS: 799264-47-4; 1-Tosyl-1H-Benzo[d]Imidazol-2-Amine

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  • 934-32-7 = 799264-47-4
    反应条件:1.1 Catalysts: Triethylamine,4-(Dimethylamino)Pyridine Solvents: Dichloromethane; Rt
    标题:A Substituted Sulfonamide And Its Co (Ii),Cu (Ii),And Zn (Ii) Complexes As Potential Antifungal Agents
    作者:Diaz,Jorge R. A.; Et Al
    参考文献:Journal Of Enzyme Inhibition And Medicinal Chemistry 日期:2016 卷标:31 页码:51-62]

    10605-21-7 = 799264-47-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Reflux1.2 Reagents: Hydrochloric Acid Solvents: Water; Acidified,Cooled2.1 Reagents: Triethylamine Solvents: Acetone; Rt; 4 H,Rt
    标题:Benzazoles. Part I. Regioselective Arylsulfonylation Of Benzimidazol-2-Amine
    作者:Kaipnazarov,T. N.; Et Al
    参考文献:Russian Journal Of Organic Chemistry 日期:2013 卷标:49(1) 页码:108-111]

    934-32-7 = 799264-47-4
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Acetonitrile,Water; 1 - 2 H,Rt
    标题:Synthesis And Biological Evaluation Of Benzimidazole Derivatives As Potential Neuroprotective Agents In An Ethanol-Induced Rodent Model
    作者:Imran,Muhammad; Et Al
    参考文献:Acs Chemical Neuroscience 日期:2021 卷标:12(3) 页码:489-505]

    16348-49-5 = 799264-47-4
    反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane; 0 °C; 3 H,0 °C -> Rt
    标题:Practical Synthesis Of N-Substituted Cyanamides Via Tiemann Rearrangement Of Amidoximes
    作者:Lin,Chia-Chi; Et Al
    参考文献:Organic Letters 日期:2014 卷标:16(3) 页码:892-895]

    1885-29-6 = 799264-47-4
    反应条件:1.1 Reagents: Hydroxylamine Solvents: Ethanol,Water; 3 H,Reflux2.1 Reagents: Diisopropylethylamine Solvents: Dichloromethane; 0 °C; 3 H,0 °C -> Rt
    标题:Practical Synthesis Of N-Substituted Cyanamides Via Tiemann Rearrangement Of Amidoximes
    作者:Lin,Chia-Chi; Et Al
    参考文献:Organic Letters 日期:2014 卷标:16(3) 页码:892-895

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专利信息


专利号:US-2024209353-A1
优先权日:2021-04-08
标 题 :Nadk2 inhibition in cancer and fibrotic disorders
发明人：THOMPSON CRAIG B; SCHWOERER SIMON; ZHU JIAJUN
权利人:MEMORIAL SLOAN KETTERING CANCER CENTER; MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES; SLOAN KETTERING INST CANCER RES
摘要:Aspects of the disclosure provide methods for inhibiting cell proliferation and protein synthesis utilizing an antagonist of nicotinamide adenine dinucleotide kinase 2 (NADK2). In some aspects, these methods are used to treat a disease such as cancer or a disorder such as a fibrotic disorder. Further provided herein are compositions comprising a nutrient-deficient cell culture medium and an antagonist of NADK2.

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主要参考文献


1: Yao N, Xing Y, Tang R, Xie C, Yang Q, Liu Y, Zhang X. Shenqi compound enhances pancreatic β-cell secretion by promoting the maturation and transport of insulin secretory vesicles through the NOD1/RIP2 signaling pathway. Front Nutr. 2026 Jan 26;12:1690849. doi: 10.3389/fnut.2025.1690849.
2: Luan Y, Yu M, Zhang H, Zhang X, Xiao P, Zhou F, Zhao T, Wang X, Wang X. NOD1/RIP2 Pathway Promotes Glioma Progression Through Microglial M2 Polarization. CNS Neurosci Ther. 2025 Dec;31(12):e70674. doi: 10.1111/cns.70674.
3: Tița O, Onache PA, Geana EI, Ciucure CT, Sumedrea DI, Florea A. Phytochemical Screening and Antioxidant Activities of White and Red Wines from Different Varieties and Wine Regions in Romania. Antioxidants (Basel). 2025 May 8;14(5):564. doi: 10.3390/antiox14050564.

合成参考文献


参考文献:10.1021/acs.jmedchem.3c02094
摘要:Russo C, Russomanno P, D'Amore VM, Alfano AI, Santoro F, Guzelj S, Gobec M, Amato J, Pagano B, Marinelli L, Carotenuto A, Tron GC, Di Leva FS, Jakopin Ž, Brancaccio D, Giustiniano M. Discovery of 2,3-Diaminoindole Derivatives as a Novel Class of NOD Antagonists. J Med Chem. 2024 Feb 22;67(4):3004–17. doi: 10.1021/acs.jmedchem.3c02094.
参考文献:10.5517/cc11q5vs
摘要:doi:10.5517/cc11q5vs
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