CAS: 75932-02-4; Fmoc-D-Lys(Fmoc)-Oh
该化合物是氨酸D-lysine的一种受保护衍生物,通常用于peptide合成和研究."Fmoc"(9-氟聚乙烯-氟氧碳基)组是氨基功能的保护群体,允许在peptide组装过程中有选择性地作出反应.该化合物的特点是两个Fmoc组,一个在alpha-amino组,另一个在lysine侧链的epsilon组,这加强了氨酸D-lysine的稳定性和溶性.D-lysine配置表明,氨基酸具有特定的立体化学特性,可以影响由此产生的peptide的生物活动和特性.N-N-di-Foc-D-Lysine通常用于固基聚合成,有助于形成复杂的peptide,同时尽量减少侧反应.其分子结构有助于其在各种生物化学应用中的效用,包括药物研制和对蛋白质的正确储存和研究.与许多化学物质的正确储存条件保持.
- 英文名称Fmoc-D-Lys(Fmoc)-Oh
- 中文名称N2,N6-双(((9H-芴-9-基)甲氧基)羰基)-D-赖氨酸
- IUPAC名称N2,N6-bis(((9H-fluoren-9-yl)methoxy)carbonyl)-D-lysine
- 其它别名N-α,N-ε-di-Fm°C-D-lysine; N-a,N-e-di-Fm°C-D-lysine; N-.ALPHA.,N-.EPSILON.-DI-FM°C-D-LYSINE
- CAS编号75932-02-4
- MFCD编号:MFCD00270743
- FDA UNII编号:CKT7KK8EK6
- 分子式:C36H34N2O6分子量:590.66
- 产品CID: 1751234
- 产品分类有机原料→生命科学→氨基酸及其衍生物→赖氨酸及其衍生物
相似化合物
10009-20-8 105047-45-8 106719-44-2物理性质
MSDS等安全信息
上下游产品
L-lysine N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide L-Lysine hydr°Chloride (fluorenylmethoxy)carbonyl chlorideL-lysine (S)-2,6-Diamino-hexanoic acid {2-[2-(2,4-dichloro-phenoxy)-acetylamino]-ethyl}-amide α,Nε-bis-Fm°C-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamineN-(Nα,Nε-bis-Fm°C-L-Lys)-O-(4,4'-dimethoxytrityl)-O'-(tert-butyldimethylsilyl)diethanolamine合成工艺路线路线简述
📜(9H-Fluoren-9-yl)Methyl Azidoformate,D-赖氨酸盐酸盐置于正己烷,乙酸乙酯,盐酸,水,碳酸氢钠,Brine,Magnesium Sulfate体系中,用 Disodium;Carbonate,丙酮,水 作为反应溶剂,化学反应 16.0H,反应生成 N,N'-二芴甲氧羰基-D-赖氨酸
参考文献:Derivatives Of Polyene Macrolide Antibiotics Containing An Amino Sugar
标题:Derivatives Of Polyene Macrolide Antibiotics Containing An Amino Sugar
摘要:本发明涉及一种聚烯酮大环内酯抗生素衍生物,其中包含一种氨基糖基团,其制备过程以及包含它们的制药组合物,用于治疗真菌感染.
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.
专利号:WO-2023090935-A1
优先权日:2021-11-18
标 题 :Method for producing agm peptides that bind specifically to nucleolin
发明人：KIM JAE IL; HWANG KOOK SANG; LEE JU YOUNG; KIM DONG MIN; WON SUN WOO; JO EUN JIN
权利人:ANYGEN CO LTD
摘要:According to the production method of the present invention, AGM peptides that bind specifically to nucleolin can be obtained with high purity and high yields. Accordingly, a method that enables the mass-synthesis of AGM peptides that can be usefully used for diagnosis and targeted drug delivery in cancer therapy, can be presented.
专利号:JP-6192657-B2
优先权日:2011-12-23
标 题 :Method for the synthesis of therapeutic peptides
专利号:US-2015045534-A1
优先权日:2011-12-23
标题:Process for the Synthesis of Therapeutic Peptides
专利号:US-2017137489-A1
优先权日:2011-12-23
标题 :Process for the Synthesis of Therapeutic Peptides
专利号:EP-2794634-A1
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.合成参考文献
合成方法参考DOI号:10.1134/S1068162007010153
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