参考标题:Development Of An Asymmetric Trimethylenemethane Cycloaddition Reaction: Application In The Enantioselective Synthesis Of Highly Substituted Carbocycles 作者:Barry M. Trost,Steven M. Silverman,James P. Stambuli |发布日期:2011.12.7 摘要:Azetidine Structures, Is Discussed. The Conditions Developed To Effect An Asymmetric Tmm Reaction Using 2-Trimethylsilylmethyl Allyl Acetate Were Shown To Be Tolerant Of A Wide Variety Of Alkene Acceptors, Providing The Desired Methylenecyclopentanes With High Levels Of Enantioselectivity. The Donor Scope Was Also Explored, And Substituted Systems Were Tolerated, Including One Bearing A Nitrile Moiety. These