CAS: 6833-84-7; Ammonium Ionophore I

该化合物是某些物种的静脉瘤细菌产生的聚醚抗生素,其特征是复杂的循环结构,包括多种醚联系,有助于其独特的特性.非活性表现出高度的亲脂性,使其能与生物膜有效互动.这种复合体以其能够形成复合物,特别是钾离子,它扰乱细胞离子软化,并可能导致抗微生物效应而闻名.非活性已经研究过其在微生物学和药理学中的潜在应用,特别是在其电离疗法活动方面.此外,它还被用于研究研究膜传输机制和离子选择性.在各种条件下,其稳定性和相对较低的毒性使它在实验室和可能的治疗环境中成为有价值的复合体.但是,像许多抗生素一样,必须谨慎地管理其使用,以防止微生物群的抗药性发展.

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CAS号159247-96-8 | CAS号159153-50-1 (R)-2-((2R,5S)-... | CAS号165689-76-9 benzyl 8-tert-b...

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    专利号:WO-2025056767-A1
    优先权日:2023-09-15
    标题 :Process for the preparation of enantiomerically enriched aliphatic amines
    发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.

    专利号:US-8153817-B2
    优先权日:2006-09-12
    标 题 :Synthesis of methyl nonactate derivatives
    发明人:BERGMEIER STEPHEN C; PRIESTLEY NIGEL D
    权利人:BERGMEIER STEPHEN C; PRIESTLEY NIGEL D; UNIV OHIO
    摘要:Methyl nonactate is converted into a variety of different triazoloamide antibacterial agents by a reaction scheme involving (1) inversion of the secondary alcohol of the methyl nonactate to produce the corresponding azidoester, (2) converting the azido ester to the corresponding azidoamide, and (3) converting the azido group of the azidoamide to a triazole to produce the corresponding triazoloamide.

    专利号:US-2008096271-A1
    优先权日:2006-10-20
    标题 :Polymeric self-assembly multiplayer membranes for ion screening: design, fabrication and application in sensors
    发明人:ZHOU JICANG; LI QING
    权利人:HONEYWELL INT INC
    摘要:The embodiments of the invention are related to an extrinsically compensated multilayer membrane comprising at least a first layer comprising charged polymers and a second layer comprising neutral polymers, wherein the first layer is characteristic of extrinsic compensation and the charges on the polymer are balanced by mobile counter ions. The embodiments of the invention relate to: i) extrinsically compensated membrane for ion screening; ii) two types of polymers for fabricating the extrinsically compensated membrane; iii) driving force for self-assembly and approaches to create such a driving force between the two polymers, which involve the functionalization of the two types of polymers via functional moieties: donors and acceptors; iv) one or more approaches of synthesis of the two types of polymers; v) the fabrications of extrinsically compensated membrane with the two types of polymers; and vi) the fabrication of functional sensing membranes and the sensors thereof.

    专利号:WO-2021074309-A1
    优先权日:2019-10-16
    标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)

    专利号:WO-2021074311-A1
    优先权日:2019-10-16
    标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens
    发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN
    权利人:SYNGENTA CROP PROTECTION AG
    摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)

    专利号:US-7101684-B2
    优先权日:1995-07-06
    标 题:Modified modular polyketide synthase
    发明人:KHOSLA CHAITAN; PIEPER REMBERT; LUO GUANGLIN; CANE DAVID
    权利人:UNIV BROWN RES FOUND
    摘要:Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides.

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    主要参考文献


    1: Peter T, Bissinger R, Lang F. Erythrocyte Shrinkage and Cell Membrane Scrambling after Exposure to the Ionophore Nonactin. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):107-12. doi: 10.1111/bcpt.12455. Epub 2015 Sep 11. doi: 10.1139/cjm-2016-0248. Epub 2016 Jun 10. doi: 10.1016/j.bmcl.2008.12.096. Epub 2008 Dec 30.
    4: Woo AJ, Strohl WR, Priestley ND. Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid. Antimicrob Agents Chemother. 1999 Jul;43(7):1662-8.
    5: Rong J, Nelson ME, Kusche B, Priestley ND. Nonactin biosynthesis: unexpected patterns of label incorporation from 4,6-dioxoheptanoate show evidence of a degradation pathway for levulinate through propionate in Streptomyces griseus. J Nat Prod. 2010 Dec 27;73(12):2009-12. doi: 10.1021/np100421v. Epub 2010 Dec 7. doi: 10.1021/ja9050235.

    合成参考文献


    摘要:CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980, 2(393), 1980
    参考文献:10.1021/ol0609661
    摘要:Wu Y, Sun YP. Synthesis of nonactin and the proposed structure of trilactone. Org Lett. 2006 Jun 22;8(13):2831–4. doi: 10.1021/ol0609661.
    参考文献:10.1007/s00294-008-0184-z
    摘要:López-Mirabal HR, Winther JR, Kielland-Brandt MC. Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase. Curr Genet. 2008 May;53(5):275–86. doi: 10.1007/s00294-008-0184-z.
    参考文献:10.1007/s00232-015-9852-3
    摘要:Efimova SS, Malev VV, Ostroumova OS. Effects of Dipole Potential Modifiers on Heterogenic Lipid Bilayers. The Journal of Membrane Biology. 2015 Oct 10;249(1-2):97–106. doi: 10.1007/s00232-015-9852-3.
    参考文献:10.1007/bf02836614
    摘要:Stastná J, Goodfellow M, Kristůfek V, Novotná J, Jizba J, Cáslavská J, Kofronová O, Blumauerová M. Characteristics of Streptomyces globisporus strain 0234A forming endospores in submerged cultures. Folia Microbiol (Praha). 1992;37(2):111–6. doi: 10.1007/bf02836614.
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