专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-8153817-B2 优先权日:2006-09-12 标 题 :Synthesis of methyl nonactate derivatives 发明人:BERGMEIER STEPHEN C; PRIESTLEY NIGEL D 权利人:BERGMEIER STEPHEN C; PRIESTLEY NIGEL D; UNIV OHIO 摘要:Methyl nonactate is converted into a variety of different triazoloamide antibacterial agents by a reaction scheme involving (1) inversion of the secondary alcohol of the methyl nonactate to produce the corresponding azidoester, (2) converting the azido ester to the corresponding azidoamide, and (3) converting the azido group of the azidoamide to a triazole to produce the corresponding triazoloamide.
专利号:US-2008096271-A1 优先权日:2006-10-20 标题 :Polymeric self-assembly multiplayer membranes for ion screening: design, fabrication and application in sensors 发明人:ZHOU JICANG; LI QING 权利人:HONEYWELL INT INC 摘要:The embodiments of the invention are related to an extrinsically compensated multilayer membrane comprising at least a first layer comprising charged polymers and a second layer comprising neutral polymers, wherein the first layer is characteristic of extrinsic compensation and the charges on the polymer are balanced by mobile counter ions. The embodiments of the invention relate to: i) extrinsically compensated membrane for ion screening; ii) two types of polymers for fabricating the extrinsically compensated membrane; iii) driving force for self-assembly and approaches to create such a driving force between the two polymers, which involve the functionalization of the two types of polymers via functional moieties: donors and acceptors; iv) one or more approaches of synthesis of the two types of polymers; v) the fabrications of extrinsically compensated membrane with the two types of polymers; and vi) the fabrication of functional sensing membranes and the sensors thereof.
专利号:WO-2021074309-A1 优先权日:2019-10-16 标 题:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; SEN INDIRA; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-3,4-dihydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-3,4-dihydroisoquinoline derivative of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale) when spayed on plants), as well as comparative data against three prior art compounds (e.g. pages 52 to 85; formulation examples; examples A1 to A3; table E; compounds E.01 to E.187; biological examples). Exemplary compounds are e.g.: 5-bromo-1-(8-fluoro-3-quinolyl)spiro[4H-isoquinoline-3,1'- cyclopropane] (example A1) 5-bromo-1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline (example A2) 1-(8-fluoro-3-quinolyl)-3,3-dimethyl-4H-isoquinoline-5-carbonitrile (example A3)
专利号:WO-2021074311-A1 优先权日:2019-10-16 标题:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives as fungicides for combating specific phytopathogens 发明人:WEISS MATTHIAS; QUARANTA LAURA; BOU HAMDAN FARHAN; MAHAJAN ATUL; WILLIAMS SIMON; KILARU JAGADEESH; BIERI STEPHANE; DIGGELMANN MARTIN 权利人:SYNGENTA CROP PROTECTION AG 摘要:1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) as well as a method of combating, preventing or controlling the phytopathogens Mycosphaerella graminicola (Septoria tritici), Fusarium culmorum, Gibberella zeae (Fusarium graminearum) and Monographella nivalis (Microdochium nivale), which comprises applying to the phytopathogen, to the locus of the phytopathogen, or to a plant susceptible to attack by the phytopathogen, or to propagation material thereof, a fungicidally effective amount of a 1-(3-quinolyl)-1,2,3,4-tetrahydroisoquinoline derivatives of formula (I). The present description discloses the synthesis of exemplary compounds, formulation examples, relevant biological data (antifungal activity against Mycosphaerella graminicola, Monographella nivalis, Fusarium culmorum and/or Gibberella zeae when spayed on plants) (e.g. pages 47 to 55; examples A1 and A2; compounds E.01 to E.17; table E). An exemplary compounds is e.g.: 3-(5-bromo-3,3-dimethyl-2,4-dihydro-1 H-isoquinolin-1-yl)-8-fluoro- quinoline (example A1)
专利号:US-7101684-B2 优先权日:1995-07-06 标 题:Modified modular polyketide synthase 发明人:KHOSLA CHAITAN; PIEPER REMBERT; LUO GUANGLIN; CANE DAVID 权利人:UNIV BROWN RES FOUND 摘要:Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides.
1: Peter T, Bissinger R, Lang F. Erythrocyte Shrinkage and Cell Membrane Scrambling after Exposure to the Ionophore Nonactin. Basic Clin Pharmacol Toxicol. 2016 Feb;118(2):107-12. doi: 10.1111/bcpt.12455. Epub 2015 Sep 11. doi: 10.1139/cjm-2016-0248. Epub 2016 Jun 10. doi: 10.1016/j.bmcl.2008.12.096. Epub 2008 Dec 30. 4: Woo AJ, Strohl WR, Priestley ND. Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid. Antimicrob Agents Chemother. 1999 Jul;43(7):1662-8. 5: Rong J, Nelson ME, Kusche B, Priestley ND. Nonactin biosynthesis: unexpected patterns of label incorporation from 4,6-dioxoheptanoate show evidence of a degradation pathway for levulinate through propionate in Streptomyces griseus. J Nat Prod. 2010 Dec 27;73(12):2009-12. doi: 10.1021/np100421v. Epub 2010 Dec 7. doi: 10.1021/ja9050235.
合成参考文献
摘要:CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980, 2(393), 1980 参考文献:10.1021/ol0609661 摘要:Wu Y, Sun YP. Synthesis of nonactin and the proposed structure of trilactone. Org Lett. 2006 Jun 22;8(13):2831–4. doi: 10.1021/ol0609661. 参考文献:10.1007/s00294-008-0184-z 摘要:López-Mirabal HR, Winther JR, Kielland-Brandt MC. Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase. Curr Genet. 2008 May;53(5):275–86. doi: 10.1007/s00294-008-0184-z. 参考文献:10.1007/s00232-015-9852-3 摘要:Efimova SS, Malev VV, Ostroumova OS. Effects of Dipole Potential Modifiers on Heterogenic Lipid Bilayers. The Journal of Membrane Biology. 2015 Oct 10;249(1-2):97–106. doi: 10.1007/s00232-015-9852-3. 参考文献:10.1007/bf02836614 摘要:Stastná J, Goodfellow M, Kristůfek V, Novotná J, Jizba J, Cáslavská J, Kofronová O, Blumauerová M. Characteristics of Streptomyces globisporus strain 0234A forming endospores in submerged cultures. Folia Microbiol (Praha). 1992;37(2):111–6. doi: 10.1007/bf02836614.