120-92-3 = 611-10-9 反应条件:1.1R:Nah,S:Phme,2-3 H,100°C; 0.5 H,100°C 标题:Coumarin-Dithiocarbamate Hybrids As Novel Multitarget Ache And Mao-B Inhibitors Against Alzheimer'S Disease: Design,Synthesis And Biological Evaluation 作者:By He,Qi Et Al 参考文献:Bioorganic Chemistry 日期:2018 卷标:81 页码:512-528]
1576-35-8 + 1119-51-3 = 611-10-9 反应条件:1.1R:Mg,S:Et2O,S:Thf,Rt; 15 Min,Rt1.2S:Et2O,S:Thf,-78°C; 2 H,-78°C1.3R:Nh4Cl,S:H2O2.1S:Meoh,Overnight,Rt -> 45°C3.1R:O2,R:O3,S:Ch2Cl2,10 Min,-78°C3.2R:Et3N,-78°C -> Rt; 3 H,Rt 标题:On The Ozonolysis Of Unsaturated Tosylhydrazones As A Direct Approach To Diazocarbonyl Compounds 作者:By Fegheh-Hassanpour,Younes Et Al 参考文献:Organic & Biomolecular Chemistry 日期:2018 卷标:16(16) 页码:2876-2884]
141-28-6 = 611-10-9 反应条件:1.1R:K,S:Phme,5 Min,Rt 标题:Potassium 作者:By Luche,Jean-Louis 参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:From E-Eros Encyclopedia Of Reagents For Organic Synthesis 页码:1-3]
141-28-6 = 611-10-9 反应条件:1.1R:Nah,S:Phme,45°C 标题:Sodium Hydride 作者:By Gawley,Robert E. 参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2006 卷标:From E-Eros Encyclopedia Of Reagents For Organic Synthesis 页码:1-9]
141-28-6 = 611-10-9 反应条件:1.1R:T-Buok,S:Phme 标题:Cascade Approaches Towards The Synthesis Of Daphnioldhanin A Alkaloid 作者:By Khan,Ashna Ashneen 参考文献:No Pp.; 2009 日期:2009 页码:From No Pp.]
108-93-0 = 611-10-9 反应条件:1.1R:Hno3,S:H2O,5-6 H,Reflux1.2C:H2So4,S:Phme,75-78°C2.1R:Na,C:Etoh,S:Benzene,8 H,Reflux 标题:A Novel Toxic Alkaloid From Poison Hemlock (Conium Maculatum L.,Apiaceae): Identification,Synthesis And Antinociceptive Activity 作者:By Radulovic,Niko Et Al 参考文献:Food And Chemical Toxicology 日期:2012 卷标:50(2) 页码:274-279]
141-28-6 = 611-10-9 反应条件:1.1R:Na,S:Phme,Rt -> 120°C; 2 H,120°C; 7 H,120°C1.2R:Acoh 标题:Synthesis Of 6,7-Dihydro-5H-Cyclopenteno[b]Pyridine 作者:By Ge,Yigang Et Al 参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2006 卷标:37(9) 页码:586-587]
924-44-7 = 611-10-9 反应条件:1.1R:Ethidine,1 H,25°C 标题:Carbonyl-Assisted Reverse Regioselective Cascade Annulation Of 2-Acetylenic Ketones Triggered By Ru-Catalyzed C-H Activation 作者:By Gollapelli,Krishna Kumar Et Al 参考文献:Chemical Science 日期:2016 卷标:7(7) 页码:4748-4753]
141-28-6 = 611-10-9 反应条件:1.1R:Et3N,R:Alcl3 标题:Phosphate Tricyclic Coumarin Analogs As Steroid Sulfatase Inhibitors: Synthesis And Biological Activity 作者:By Kozak,Witold Et Al 参考文献:Rsc Advances 日期:2014 卷标:4(84) 页码:44350-44358]
141-28-6 = 611-10-9 反应条件:1.1R:Na,S:Phme,110°C1.2R:Acoh,S:H2O 标题:Regioselective Ketone α-Alkylation With Simple Olefins Via Dual Activation 作者:By Mo,Fanyang And Dong,Guangbin 参考文献:Science (Washington 日期:2014 卷标:345(6192) 页码:68-72]
120-92-3 = 611-10-9 反应条件:1.1R:Caco3,R:Cao,C:C16H33N+me3 cl-,S:Dioxane,3 H,25°C 标题:Facile Carbethoxylation And Carbamoylation Of Ketones 作者:By Pazdera,Pavel And Simbera,Jan 参考文献:Organic Preparations And Procedures International 日期:2011 卷标:43(3) 页码:297-301
己二酰氯置于三乙胺,苯体系中,化学反应生成 2-氧代环戊羧酸乙酯 参考文献:Sauer,Journal Of The American Chemical Society,1947,Vol. 69,P. 2446 标题:Sauer,Journal Of The American Chemical Society,1947,Vol. 69,P. 2446
专利号:US-12098115-B2 优先权日:2016-09-15 标 题:Methods and compositions for terpenoid synthesis 发明人:GRENNING ALEXANDER JAMES 权利人:UNIV FLORIDA 摘要:In one aspect, the disclosure relates to methods for preparation of terpene and terpene-like molecules. In a further aspect, the disclosure relates to the products of the disclosed methods, i.e., terpene and terpene-like molecules prepared using the disclosed methods. Intermediates for the synthesis of a wide variety of terpenoids are γ-allyl Knoevenagel adducts or quasi γ-allyl Knoevenagel adducts are disclosed. In various aspects, methods of preparing terpenoids through these intermediates are disclosed. The methods can comprise α-alkylation of an allylic electrophile followed by ring-closure metathesis to a polycyclic terpenoid structure. In a further aspect, the disclosure pertains to terpenoid frameworks, and compounds prepared via disclosed oxidation and substitution reactions on the disclosed terpenoid frameworks. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
专利号:US-2025147014-A1 优先权日:2022-02-14 标题:Plasmon-enhanced fluorescence biochemical sensors 发明人:PINCHUK ANATOLI; SERGEYEVA TETYANA; YARYNKA DARIA; CHEGEL VLADIMIR; LOPATYNSKYI ANDRI 权利人:UNIV COLORADO REGENTS; THE REGENTS OF THE UNIV OF COLORADO A BODY 摘要:A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.
专利号:US-12378246-B2 优先权日:2019-04-11 标 题:Synthetic options towards the manufacture of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6-oxo-1(6H)-pyrimidinyl} - 1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-11,15-(metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one 发明人:CUNIERE NICOLAS; FAN YU; KOLOTUCHIN SERGEI; MUKHERJEE SUBHA; SIMMONS ERIC M; SINGH AMARJIT; WEI CAROLYN S; XIAO YI; YUAN CHANGXIA; ZHENG BIN; WAGSCHAL SIMON ALBERT; BROGGINI DIEGO FERNANDO DOMENICO; CAO DUY CHI TRUNG; CHERNICHENKO KOSTIANTYN; LEMAIRE SEBASTIEN FRANCOIS EMMANUEL; BEN HAÃ?M CYRIL 权利人:BRISTOL MYERS SQUIBB CO; JANSSEN PHARMACEUTICA NV 摘要:Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.
专利号:US-9220795-B2 优先权日:2011-09-22 标题 :Indole derivatives 发明人:WADSWORTH HARRY JOHN; O'SHEA DENNIS; PASSMORE JOANNA; TRIGG WILLIAM; EEWAN AMANDA; SHAN BO 权利人:GE HEALTHCARE LTD 摘要:An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
专利号:US-8790619-B2 优先权日:2009-03-27 标题 :Indole derivatives 发明人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; EWAN AMANDA 权利人:WADSWORTH HARRY JOHN; SHAN BO; O'SHEA DENNIS; PASSMORE JOANNA MARIE; TRIGG WILLIAM JOHN; EWAN AMANDA; GE HEALTHCARE LTD 摘要:An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent of the invention, as well as a method for synthesis of said in vivo imaging agent comprising use of said precursor compound, and a kit for carrying out said method. Also provided is a cassette for automated synthesis of the in vivo imaging agent. Further aspects of the invention include a radiopharmaceutical composition comprising the in vivo imaging agent of the invention, and methods for the use of said in vivo imaging agent.
专利号:US-4385062-A 优先权日:1980-01-09 标题 :1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents 发明人:CIABATTI ROMEO; PADOVA GIOVANNA 权利人:LEPETIT SPA 摘要:1-[(2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives of the formula ##STR1## wherein R, R 1 , and R 2 , each independently, represent hydrogen or a (C 1 -C 4 )alkyl radical, n represents the integer 1, 2, 3, 4, or 5, and, in each of the n (CR' 2 ) groups, R' represents hydrogen or (C 1 -C 4 )alkyl, are described as well as the process for their manufacture, the intermediates for their synthesis and their use as antihypertensive agents.