专利号:WO-2018167780-A1 优先权日:2017-03-12 标题 :Methods of prognosing and treating cancer 发明人:EREZ AYELET; RUPPIN EYTAN; LEE JOO SANG; KARATHIA HIREN; HANNENHALLI SRIDHAR 权利人:YEDA RES & DEV; UNIV MARYLAND 摘要:Methods of treating cancer are provided. Accordingly there is provided a method of treating cancer in a subject in need thereof, the method comprising determining a shift from the urea cycle to pyrimidine synthesis in a cancerous cell of the subject as compared to a control sample; and treating the subject with an immune modulating agent when the shift is indicated. Also provided are methods of prognosing cancer and treating cancer according to the prognosis.
专利号:WO-2009045637-A9 优先权日:2007-08-10 标 题 :Methods for the synthesis of acrylic acid and derivatives from fumaric acid
专利号:US-12098218-B2 优先权日:2015-12-17 标题 :Process for the manufacture of degarelix and its intermediates 发明人:RICCI ANTONIO; ZANON JACOPO; CABRI WALTER; GURYANOV IVAN; ORLANDIN ANDREA; BIONDI BARBARA; FORMAGGIO FERNANDO; VISENTINI DARIO 权利人:FRESENIUS KABI IPSUM S R L 摘要:The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.
专利号:US-2018161300-A1 优先权日:2015-05-11 标题:Citrin inhibitors for the treatment of cancer 发明人:EREZ AYELET; RABINOVICH SHIRAN; SILBERMAN ALON; AGRON SHANI 权利人:YEDA RES & DEV; YEDA RES & DEV 摘要:Provided are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of an agent which downregulates a mitochondrial aspartate-dependent pyrimidine synthesis, thereby treating the cancer.
专利号:US-2017008828-A1 优先权日:2007-08-10 标题:Methods for the synthesis of olefins and derivatives
专利号:EP-2188243-A2 优先权日:2007-08-10 标题:Methods for the synthesis of acrylic acid and derivatives from fumaric acid
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合成参考文献
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