CAS: 564483-19-8; Di-Tert-Butyl(2',4',6'-Triisopropyl-[1,1'-Biphenyl]-2-yl)Phosphine

上下游产品

di(tert-butyl)chlorophosphine 2-bromo-1-chlorobenzene 2,4,6-triisopropyl-1-bromobenzene di-tert-butylphosphine tert-butyl 2-(benzamido)-4-(3-methoxyphenoxy)benzoate tert-butyl 2-(benzamido)-4-(3-nitrophenoxy)benzoate tert-butyl 2-(benzamido)-4-(3,5-difluorophenoxy)benzoate tert-butyl 2-(benzamido)-4-(4-methylphenoxy)benzoate

二叔丁基氯化膦,2-溴氯苯,2-溴-1,3,5-三异丙苯置于magnesium,1,2-二溴乙烷,Copper(L) Chloride体系中,用 四氢呋喃 作为反应溶剂,化学反应 22.0H,以32%的收率获得产物2-二-叔丁膦基-2',4',6'-三异丙基联苯
参考文献:扩展 Pd 催化的 Cn 键形成过程:芳基磺酸盐的首次酰胺化,水性胺化以及与 Cu 催化反应的互补
标题:扩展 Pd 催化的 Cn 键形成过程:芳基磺酸盐的首次酰胺化,水性胺化以及与 Cu 催化反应的互补
摘要:Pd催化芳基甲苯磺酸酯和苯磺酸酯胺化的第一种通用方法是利用配体1开发的,该配体属于新一代联芳基单膦配体.此外,新的催化剂系统首次实现了芳基芳烃磺酸盐的酰胺化和不需要使用助溶剂的水性胺化方案.底物范围已显着扩大到包括含有伯酰胺和游离羧酸基团的芳基卤化物.在多功能基板的情况下,Pd 催化的胺化可以提供与 Cu 催化的 Cn 键形成过程互补的选择性.
DOI:10.1021/ja035483W

专利信息

专利号:US-2015336866-A1
优先权日:2013-01-01
标题:Synthesis of difluoromethyl ethers and sulfides
发明人：HARTWIG JOHN; FIER PATRICK
权利人:UNIV CALIFORNIA
摘要:The synthesis of difluoromethyl ethers and sulfides with a simple, non-ozone-depleting reagent is described. The difluoromethylation of phenols with this reagent occurs at room temperature within minutes with exceptional functional group tolerance. The mild conditions makes possible tandem processes for the conversion of aryl boronic acids, aryl halides and arenes to difluoromethyl ethers. Mechanistic studies support a reaction pathway involving nucleophilic attack of the phenolate to difluorocarbene.

专利号:US-11512062-B2
优先权日:2018-10-15
标 题:Process for the synthesis of piperazinyl-ethoxy-bromophenyl derivates and their application in the production of compounds containing them
发明人：BEAUREGARD LOUIS-PHILIPPE; BERTRAND MARTIAL; GIGUERE PASCALL; HARDOUIN CHRISTOPHE; SCHIAVI BRUNO
权利人:SERVIER LAB
摘要:Process for the industrial synthesis of the compound of formula (I):

专利号:US-2024336649-A1
优先权日:2021-06-21
标 题 :Synthesis of covalent protein dimers that can inhibit myc-driven transcription
发明人：LOAS ANDREI; PENTELUTE BRADLEY L; POMPLUN SEBASTIAN; JBARA MUHAMMAD; SCHISSEL CARLY KATHERINE; RODRIQUEZ JACOB JOSHUA LEE; BUCHWALD STEPHEN LEFFLER; BOIJA ANN; KLEIN ISAAC; HAWKEN SUSANA WILSON; LI CHARLES HAN
权利人:MASSACHUSETTS INST TECHNOLOGY; WHITEHEAD INSTITUTE OF BIOMEDICAL RES
摘要:The disclosure relates to covalent protein dimers of MYC, MAX, and Omomyc; pharmaceutical compositions comprising the covalent protein dimers; methods of making the covalent protein dimers; and methods of treating disorders associated with MYC dysregulation (e.g., cancer) with the covalent protein dimers.

专利号:US-12049470-B2
优先权日:2021-02-01
标 题 :MK2 inhibitors, the synthesis thereof, and intermediates thereto
发明人：RUCHELMAN ALEXANDER L; COOMBS JOHN R; ZHU KEMING; LIM DANIEL; JOE CANDICE LEE; GEORGE DAVID T; ZHENG BIN; LIN DONG
权利人:CELGENE CORP
摘要:The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

专利号:US-2023405565-A1
优先权日:2022-06-21
标 题:Catalyst composition for biaryl synthesis by decarboxylative cross-coupling
发明人：LIM CHERN-HOOI; QIAN GANG; ELDER WILLIAM ZACHARY; RILEY PAIGE; KOLVENBACH ROBIN; WALTER PHILIPP; GOCK MICHAEL
权利人:HERAEUS DEUTSCHLAND GMBH & CO KG; NEW IRIDIUM INC
摘要:The present invention relates to a catalyst composition for synthesis of heteroaromatic biaryls by a light-assisted decarboxylative carbon-carbon cross-coupling reaction, wherein the composition comprises(i) a palladium compound which is selected from a palladium salt or a palladium complex or a mixture thereof,(ii) at least one of the following compounds:a compound of Formula (I)a compound of Formula (II)an iridium complex comprising ligands L1, L2 and L3, wherein the ligands L1, L2 and L3 are selected, independently from each other, from a phenylpyridine and a bipyridine.

专利号:US-2024208926-A1
优先权日:2021-03-24
标题:New process for the synthesis of 5-{5-chloro-2-[(3s)-3-[(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
发明人：PIN FRÉDÉRIC; PETHÖ Bà LINT
权利人:SERVIER LAB; NOVARTIS AG
摘要:The present invention relates to a new process for preparing 5-{5-chloro-2-[(38)-3-[(morpholin-4-yl)methyl]-3.4-dihydr oisoquinoline-2(1H)-carbonyl]phenyl}-1,2-dimethyl-1/H-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds.