专利号:US-8759508-B2 优先权日:2007-05-18 标 题 :Chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides 发明人:DELANEY MICHAEL OREN 权利人:DELANEY MICHAEL OREN; GE HEALTHCARE DHARMACON INC 摘要:The compounds are of class of chromophoric 1,2,3-triazolyl equipped silyl linking groups that are useful in the chemical synthesis of RNA. An example of a nucleoside comprising this group is
专利号:US-6310180-B1 优先权日:1993-06-21 标 题 :Method for synthesis of proteins 发明人:TAM JAMES P 权利人:UNIV VANDERBILT 摘要:A method for peptide synthesis is disclosed that requires neither protecting groups nor activation of the C-α carboxyl groups. The method comprises ligating a first molecule to a second molecule by promoting the orthogonal coupling of the molecules to each other. In an aspect of this method, an acyl-type reaction occurs between the molecules. The method contemplates the joining of molecules of variant size to each other, as well as the coupling of multiple identical molecules. The invention also covers the ligation of unprotected peptide, proteins or nonpeptide segments to prepare therapeutic products and synthetic vaccines with linear, circularized, or branched backbone structures, as well as the site-specific modification of peptides or proteins by lipidation and pegylation.
专利号:US-10732109-B2 优先权日:2017-11-28 标题 :Core-shell type nanosilica fluorescent probe and synthesis method and use thereof 发明人:XU MEIYING; LIU FEI; LIAO BING; LUO YESHEN; LI ENZE 权利人:GUANGDONG INST MICROBIOLOGY GUANGDONG DETECTION CT MICROBIOLOGY; GUANGDONG ACAD OF SCIENCES 摘要:Disclosed are a core-shell type nanosilica fluorescent probe and a synthesis method thereof, wherein the core-shell type nanosilica fluorescent probe is a nanoparticle with a core-shell structure. Also disclosed is a method using the core-shell type nanosilica fluorescent probe for selection of functional microorganisms having toxic aromatic hydrocarbon degrading activity, wherein the method enables efficient, intuitive and rapid specificity sorting and analyzing of individual cells with high sensitively.
专利号:WO-2006025724-A1 优先权日:2004-09-02 标题:IMPROVEMENTS TO SYNTHESIS, PHARMACEUTICAL COMPOSITIONS AND USES OF SODIUM PENTABORATE PENTAHYDRATE (NaB5O8.5H2O) 发明人:GALVAN PEREZ JUAN PABLO 权利人:GALVAN PEREZ JUAN PABLO 摘要:The invention relates to an improved method for the synthesis of sodium pentaborate pentahydrate (NaB5O8.5H2O), consisting in reacting disodium tetraborate decahydrate (DTBD, Borax) and orthoboric acid (OBA, boric acid). The inventive method is performed over a period of no more than five days and does not require the use of fungal strains. The invention also relates to the product thus obtained, which is intended to boost the immune system against ailments caused by bacteria and viruses, to the pharmaceutical compositions thereof and to the use of same in relation to said ailments.
专利号:EP-1749870-B1 优先权日:2005-08-04 标 题:Fluorescein-based compounds and their use for peptide synthesis 发明人:BALAKIREV MAXIM; BURCHAK OLGA 权利人:COMMISSARIAT ENERGIE ATOMIQUE 摘要:The present invention is related to new fluorescein derivatives, the method for producing such derivatives and their use for the synthesis of fluorogenic peptides and in particular protease substrates and peptide ligands.
专利号:US-9845501-B2 优先权日:1998-12-14 标题 :System and methods for nucleic acid sequencing of single molecules by polymerase synthesis 发明人:WILLIAMS JOHN G K 权利人:PACIFIC BIOSCIENCES CALIFORNIA INC; PACIFIC OF BIOSCIENCES OF CALIFORNIA INC 摘要:This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created.
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合成参考文献
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