CAS: 4151-50-2; Sulfluramid

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CAS号307-35-7 全氟辛基磺酰氟 | CAS号75-04-7 乙胺 | CAS号1691-99-2 N-乙基全氟辛基磺酰胺乙醇 | CAS号2991-50-6 2-(N-乙基全氟辛烷磺酰氨基)乙酸

📜全氟辛基磺酰氟,乙胺置于三乙胺,碳酸氢钠体系中,用 乙醚 作为反应溶剂,化学反应 20.0H,以56%的收率获得产物氟虫胺
参考文献:与环境相关的全氟磺酰胺的合成和结构.
标题:与环境相关的全氟磺酰胺的合成和结构.
摘要:烷基化全氟辛烷磺酰胺是环境问题的化合物.为了使这些化合物可用于环境和毒理学研究,通过相应的全氟烷烃磺酰氟与合适的伯胺或仲胺反应,合成了一系列 N-烷基化全氟辛烷磺酰胺和结构相关的化合物.通过用溴乙醇直接烷基化或用乙酸2-溴-乙酯烷基化然后乙酸水解,从n-烷基全氟烷磺酰胺获得全氟烷烃磺酰胺乙醇.n-烷基全氟辛烷磺酰胺乙酸酯以类似的方式通过用溴乙酸酯对n-烷基全氟烷磺酰胺进行烷基化,然后进行碱性酯水解来合成.或者,N-烷基全氟烷烃磺酰胺可以使用适当的醇使用光信反应进行烷基化.全氟辛烷磺酰胺是由全氟辛烷磺酰氟通过叠氮化物通过用 Zn/hcl 还原合成的.所有全氟辛烷磺酰胺均包含线性和支链 C(8)F(17) 异构体,比例通常为 20:1 至 30:1.n-乙基和n,N-二乙基全氟辛烷磺酰胺的晶体结构表明sn键具有相当大的双键特性.这种双键特性导致围绕 Sn 键的显着旋转障碍(deltag(不等于)=
DOI:10.1016/j.Jfluchem.2007.01.013

专利信息

专利号:US-12220411-B1
优先权日:2023-07-25
标题 :Application of PTGDS inhibitor in preparation of drug for treating cataracts
发明人：LI JIN; LIU JIASHENG; XU YITONG; ZHU MENGCHAO; SUN HAISEN
权利人:THE EYE HOSPITAL OR WENZHOU MEDICAL UNIV; THE EYE HOSPITAL OF WENZHOU MEDICAL UNIV
摘要:Application of a PTGDS inhibitor in preparation of a drug for treating cataracts is provided. As an effective and selective PTGDS inhibitor, AT-56 competitively inhibits production of PGD2 by occupying a catalytic site of PTGDS. The PTGDS catalyzes synthesis of the PGD2 to cause an oxidative stress injury of human lens epithelial cells, thereby promoting occurrence and development of aging and opacity of a lens. By reducing apoptosis caused by the oxidative stress injury, a degree of the cataracts can be effectively reduced.

专利号:US-2023104375-A1
优先权日:2021-10-01
标题 :Method for multiplexable strand-specific 3' end sequencing of mrna transcriptome primer set, kit and application thereof
发明人：PAN XINGHUA; Mai Liyao; CHEN CAIMING; Qiu Yinbing; LIAN ZHIWEI
权利人:SEQUMED BIOTECHNOLOGY INC; DEPARTMENT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY SOUTHERN MEDICAL UNIV
摘要:The invention discloses a primer set and a multiplexable library building scheme for constructing an RNA sequencing library with a related reagent kit and an application thereof. The invention also discloses a corresponding data analysis method and a related instrument. The primer set used for RNA sequencing library construction includes the reverse transcription primers containing poly-dT, the 2nd strand cDNA primers particularly contain a random or semi-random portion at their 3′ end for universal initiation of the synthesis at multiple sites, or sequence capturing the 1st strand of a specific cDNA, as well as their corresponding PCR primer 1 and 2. By this method, the library construction process is simple and the operation is convenient; the time of building the database was significantly shortened; it can carry out a large number of samples in a single run; the analysis process is simpler; the cost of database building, sequencing and analysis is significantly reduced.

专利号:US-2024391961-A1
优先权日:2021-08-25
标题:Autonomous organisms for synthesis of permanently phosphorylated proteins
发明人：COOLEY RICHARD B; MEHL RYAN A; ZHU PHILLIP
权利人:UNIV OREGON STATE
摘要:Embodiments of the present disclosure provide compositions and methods for biosynthesizing a stable, functional mimic of phosphoserine. The compositions and methods described herein genetically program a host cell to express a biosynthetic pathway that can synthesize the amino acid, 2-amino-4-phosphobobutyric acid, that is a non-hydrolyzable phosphoserine (nhpSer) because it contains a carbon-phosphorus, e.g., phosphonate, bond. In one embodiment the genetically programed cells express the enzymes of a pathway from a Streptomyces bacterium . In some embodiments, nhpSer is translationally incorporated into protein of interest at one or more programmed UAG amber codons using Genetic Code Expansion (GCE) technology.

专利号:US-6602714-B1
优先权日:1999-11-09
标 题:Viscosity and mass sensor for the high-throughput synthesis, screening and characterization of combinatorial libraries
发明人：TAGGE CHRISTOPHER D; WILSON JR ROBERT B; OH SEAJIN; HIRSCHON ALBERT S; PLOEGER DALE W
权利人:STANFORD RES INST INT
摘要:Workstation, apparatuses and methods for the high-throughput synthesis, screening and/or characterization of combinatorial libraries. The invention relates to an array, which permits various high-throughput methods for synthesis, screening and/or characterization in the same array, without requiring sample transfer from the array. In a preferred embodiment, the synthesis, screening, and/or characterization steps are carried out in a highly parallel fashion, where more than one compound is synthesized, screened, and/or characterized at the same time. The invention may be practiced at the microscale. The array may comprise thermal channels, for regulating the temperature of the wells in the array. The wells of the array may comprise a membrane, which is used in various screening and characterization methods. The invention also relates to a covered array, comprising the array and an array cover, as well as an apparatus comprising the array, which comprises the array, an array cover and a stage. The array, array cover, and the stage may be modified as required for a variety of synthesis and/or analysis techniques. The array is easily interchangeable between different analytical instruments, and in an embodiment, the invention relates to an automated workstation, where the array is transferred between different synthesis, screening, and characterization stations. The invention also relates to a variety of methods for synthesis, screening, and characterization, which are adapted for combinatorial chemistry. Any of the embodiments of the invention may be used either alone or taken in various combinations.

专利号:US-2025018377-A1
优先权日:2023-07-12
标题 :Catalyst formulation for direct conversion of microalgae in growth medium to biofuels
发明人：DELIISMAIL OZGUN
权利人:SOCAR TURKEY ARASTIRMA GELISTIRME VE INOVASYON A S
摘要:This invention relates to catalyst formulation to be used in direct conversion of Nannochloropsis oculata marine microalgae into biofuels and biochemicals without harvesting and dewatering and synthesis method of this formulation. In this method, nickel on silica/alumina (Ni—Al2O3—SiO2) catalyst mixture formulation is obtained by using single step sol-gel method. The catalyst mixture formulation percentages to obtain high catalytic activity and selectivity are 70% Al2O3, 30% SiO2 and 10% Ni by weight.

专利号:US-2023241088-A1
优先权日:2022-01-17
标 题 :Composition for preventing or treating lung cancer comprising ortho-topolin riboside as active ingredient
发明人：CHOI HYUNG-KYOON; LEE HWANHUI
权利人:CHUNG ANG UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION
摘要:The present disclosure relates to a composition for preventing or treating lung cancer, including ortho topolin riboside (oTR) as an active ingredient, wherein oTR showed the highest cytotoxicity among all tested compounds against NSCLC cells, oTR reduced synthesis of amino acid and pyrimidine as well as glycolytic function in NSCLC cells and xenograft tumors.