CAS: 1744-12-3; 2,2-Difluorobenzo[d][1,3]Dioxole-5,6-Diamine

上下游产品

2,2-difluoro-benzo[1,3]dioxol-5-ylamine N-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetamide N-(2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-yl)acetamide 2,2-difluoro-6-nitrobenzo[d][1,3]dioxol-5-amine 6,6-difluoro[1,3]dioxolo[4,5-f]benzimidazole

📜5-氨基-2,2-二氟-1,3-苯并二噁唑置于nitronium Tetrafluoborate,Palladium On Activated Charcoal,氢气体系中,用 环丁砜,甲醇,二氯甲烷,甲苯 用作溶剂,100.0 °C,379.22 Kpa 条件下,反应 31.0H,反应生成2,2-二氟-苯并[1,3]间二氧杂环戊烯-5,6-二胺
参考文献:碳11标记的ck1抑制剂的合成作为阿尔茨海默氏病成像的新潜在pet示踪剂
标题:碳11标记的ck1抑制剂的合成作为阿尔茨海默氏病成像的新潜在pet示踪剂
摘要:参考标准品甲基3-(((2,2-二氟-5 H-[1,3] Dioxolo [4',5':4,5]苯并[1,2-D ]咪唑-6-基)氨基甲酰基)苯甲酸酯(5A)和n-(2,2-Difluoro-5 H-[1,3] Dioxolo [4',5':4,5]苯并[1,2-D ]咪唑-6-基)-3-甲氧基苯甲酰胺(5C)及其相应的脱甲基前体3-((2,2-二氟-5 H-[1,3] Dioxolo [4',5':4,5]苯并[1,2-D ]咪唑-6-基)氨基甲酰基)苯甲酸(6A)和n-(2,2-二氟-5 H-[1,3] Dioxolo [4',5':4,5]苯并[1,2-D ]咪唑-6-基)-3-羟基苯甲酰胺(6B)由5-氨基-2,2-二氟-1,3-苯并二恶唑和3-取代的苯甲酸分5步和6步合成,总化学收率分别为33%和11%,30%和7%.碳11标记的酪蛋白激酶1(ck1)抑制剂,[
Doi:10.1016/j.Bmcl.2018.05.053

专利信息

专利号:US-7541367-B2
优先权日:2005-05-31
标 题 :3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
发明人：CHIU GEORGE; CONNOLLY PETER J; EMANUEL STUART; HUANG SHENLIN; LI SHENGJIAN; LIN RONGHUI; LU YANHUA; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.