专利号:US-12037623-B2 优先权日:2018-07-09 标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs 发明人:HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C 权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC 摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.
专利号:US-2023109627-A1 优先权日:2019-11-14 标 题:Precursor chemistry for quantum dot synthesis enabling temperature-independent modulation of reactivity 发明人:HAN HEE-SUN; PARK JOONHYUCK 权利人:UNIV ILLINOIS 摘要:Provided herein are methods of making a high-quality quantum dot (QD), including by providing anion precursor chemistry that enables chemical modulation of precursor reactivity, thereby, allowing independent optimization of reaction temperature and precursor reactivity to systematically grow high quality QDs and by providing specially configured tunable precursors and related chemistry to facilitate separate reaction pathways for nucleation and growth, thereby accessing heat-up based synthesis of high-quality QD, including core-shell QDs. The methods may include providing a base-QD and a first anion or cation precursor having a composition comprising an anion or a cation element, respectively, and a modification agent. At least one add-layer is grown on the base-QD at a growth temperature, thereby making the high-quality QD comprising the base-QD and the at least one add-layer. At least one add-layer may have a composition comprising an add-layer cation element and an add-layer anion element.
专利号:US-11873315-B2 优先权日:2017-06-16 标 题 :Chiral n-heterocyclic phosphorodiamidic acids (NHPAS) and derivatives as novel Brønsted acid catalysts 发明人:KANG JUN YONG; HUANG HAI 权利人:The Board of Regents of the Nevada System of Higher Education on Behalf of the Univ of Nevada; THE BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VE 摘要:Provided herein are diaryl and arylalkyl phosphonates, useful as intermediates in, for example, the synthesis of leukocyte elastase inhibitors, potassium channel modulators, chemiluminescence materials, and flame retardants, and methods for making same. Also provided are N-heterocyclic phosphorodiamidic acids (NHPAs) useful in reactions such as, for example, in the preparation of diaryl and arylalkyl phosphonates. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-6153777-A 优先权日:1999-11-02 标 题 :Synthesis of ansa-metallocene catalysts 发明人:JORDAN RICHARD F; ZHANG XINGWANG 权利人:UNIV IOWA RES FOUND 摘要:A process of preparing in high yield racemic ansa-metallocene complexes by reacting a chelated bisamide group 4 metal complex with an ansa-bis-cyclopentodrenyl dianion reagent. The meso isomers are not detectable in the reaction product.
专利号:US-2014083925-A1 优先权日:2012-05-17 标 题:Multi-layer Separation Membrane Formed by Molecular Layer-by-Layer Deposition of Highly Cross-linked Polyamide Films 发明人:STAFFORD CHRISTOPHER M; JOHNSON PETER M 权利人:STAFFORD CHRISTOPHER M; JOHNSON PETER M; US COMMERCE 摘要:This invention relates to the field of molecular layer-by-layer deposition processes and more specifically to the synthesis of a polymer layer relevant to a separation membrane using molecular layer-by-layer deposition of highly cross-linked polyamide films to promote consistent layer growth consistent for the formation of membrane layers having a uniform chemical composition and thickness.
专利号:US-2004241251-A1 优先权日:2001-05-04 标 题:Random or block co-or terpolymers produced by using of metal complex catalysts 发明人:THIELE SVEN K H; MONROY VICTOR M; WILSON DAVID R 摘要:Random or block co- or terpolymers produced by using metal complex catalysts in a reaction of one conjugated diene monomer with one aromatic Random or block co- or terpolymers produced by using metomers with one aromatic α-olefin or terpolymers of one conjugated diene monomer with one aromatic α-olefin and one aliphatic α-olefin by using metal complexes comprising metals of group 3 to 10 of the Periodic System of the Elements in combination with activators and optionally a support material. More particularly the metal complexes used for the synthesis of co- or terpolymer are lanthanide metals. Even more particularly diene monomer(s) and aromatic α-olefin monomer(s) such as, but not limited to, butadiene and styrene or isoprene and styrene are copolymerized giving random or block copolymers or butadiene, styrene and isoprene are terpolymerized giving random or block terpolymers using metal complexes comprising lanthanide metals in combination with activators and optionally a support material. Preferably random co- or terpolymers are formed.
[参考文献]: Chuan-Qi Yin, Et Al. Synthesis Of Dendritic Stationary Phases With Surface-Bonded L-Phenylalanine Derivate As Chiral Selector And Their Evaluation In Hplc Resolution Of Racemic Compounds. Chirality. 2008 Jul;20(7):846-55. [参考文献]: H Nohta, Et Al. High-Performance Liquid Chromatographic Determination Of Urinary Catecholamines By Direct Pre-Column Fluorescence Derivatization With 1,2-Diphenylethylenediamine. J Chromatogr. 1986 Jul 11;380(1):229-31. [参考文献]: Hiroaki Nagaoka, Et Al. Spectrofluorometric Determination Of Catechins With 1,2-Diphenylethylenediamine. Anal Sci. 2002 Aug;18(8):951-3. [参考文献]: Kaoru Fujino, Et Al. Simultaneous Determination Of 5-Hydroxyindoles And Catechols By High-Performance Liquid Chromatography With Fluorescence Detection Following Derivatization With Benzylamine And 1,2-Diphenylethylenediamine. J Chromatogr A. 2003 Sep 19;1012(2):169-77. [参考文献]: Maj-Len Henriks-Eckerman, Et Al. Role Of Dermal Exposure In Systemic Intake Of Methylenediphenyl Diisocyanate (Mdi) Among Construction And Boat Building Workers. Toxicol Lett. 2015 Feb 3;232(3):595-600.
合成参考文献
摘要:Shimada, K., Science of Synthesis Knowledge Updates, (2013) 2, 303. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. 参考文献:10.1016/j.jpba.2018.04.026 摘要:Makedonskaya MI, Veselova IA, Kalmykov SN, Shekhovtsova TN. Novel biosensing system for the simultaneous multiplex fluorescent determination of catecholamines and their metabolites in biological liquids. Journal of Pharmaceutical and Biomedical Analysis. 2018 Jul;156():133–41. doi: 10.1016/j.jpba.2018.04.026. 参考文献:10.1016/s0378-4347(00)82007-1 摘要:Mitsui A, Nohta H, Ohkura Y. High-performance liquid chromatography of plasma catecholamines using 1,2-diphenylethylenediamine as precolumn fluorescence derivatization reagent. Journal of Chromatography B: Biomedical Sciences and Applications. 1985 Jan;344():61–70. doi: 10.1016/s0378-4347(00)82007-1. 参考文献:10.1016/s0090-9556(25)08392-8 摘要:Bednarski PJ, Kratochwil NA, Otto AM. Reversible and irreversible interactions of a cisplatin analog bearing a 1,2-diphenylethylenediamine ligand with plasma and plasma proteins in vitro. Drug Metabolism and Disposition. 1994 May;22(3):419–27. doi: 10.1016/s0090-9556(25)08392-8.