CAS: 147126-62-3; (2R,5R)-(1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl 5-Hydroxy-1,3-Oxathiolane-2-Carboxylate

相似化合物

147126-63-4 200396-19-6 1638744-50-9

上下游产品

L-䓝基乙醛酸酯水合物 L-Menthyl Glyoxylate Monohydrate 111969-64-3
(1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl 2-Mercaptoacetate 74441-18-2

(1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl 2-Mercaptoacetate置于磺酰氯,水,碳酸氢钠体系中,用 甲苯 用作溶剂,化学反应 13.34H,反应生成(2R,5R)-5-羟基-1,3-氧硫杂环-2-羧酸 (1R,2S,5R)-5-甲基-2-异丙基环己酯
参考文献:约束驱动创新指导下的草硫杂环戊烷药物中间体的合成
标题:约束驱动创新指导下的草硫杂环戊烷药物中间体的合成
摘要:开发了一条用于合成拉米夫定(3Tc)和恩曲他滨(ftc)的氧杂硫杂环戊烷中间体的新路线.我们通过将自己局限于低成本,可广泛获得的起始材料来开发提出的路线,我们将其称为以供应为中心的合成.使用亚硫酰氯化学从无环前体构建氧杂硫杂环戊烷的骨架.这种键结构的选择使得能够使用氯乙酸,乙酸乙烯酯,硫代硫酸钠和水来生产氧杂硫杂环戊烷.
Doi:10.1021/acs.Oprd.0C00145

专利信息

专利号:US-8304540-B2
优先权日:2007-05-18
标题:Process for stereoselective synthesis of lamivudine
发明人：LI JINLIANG; LV FENG
权利人:LI JINLIANG; LV FENG; SHANGHAI DESANO PHARMACEUTICAL HOLDING CO LTD
摘要:The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.

专利号:US-6329522-B1
优先权日:1994-04-23
标题:Process for the diastereoselective synthesis of nucleoside analogues
发明人：HILL MALCOLM LEITHEAD; WHITEHEAD ANDREW JONATHAN; HORNBY ROY; HALLETT PETER; GOODYEAR MICHAEL DAVID; DWYER P OWEN
权利人:GLAXO GROUP LTD
摘要:The invention relates to a diastereoselective process for the preparation of compounds of formula (1), wherein W is S, S=O, SO2 or O; X is S, S=O, SO2 or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof.

专利号:US-2010063283-A1
优先权日:2007-05-18
标题 :Process for stereoselective synthesis of lamivudine

专利号:US-2011118465-A2
优先权日:2007-05-18
标 题:Process for stereoselective synthesis of lamivudine

专利号:EP-2161267-B1
优先权日:2007-05-18
标 题:A process for stereoselective synthesis of lamivudine

专利号:EP-0757684-B1
优先权日:1994-04-23
标题:Process for the diastereoselective synthesis of nucleoside analogues