专利号:US-8461357-B2 优先权日:2008-09-19 标题 :Expeditious synthesis of gibberellin A5 and esters thereof 发明人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS RICHARD P 权利人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS R P; UTI LIMITED PARTNERSHIP 摘要:An expeditious synthesis of gibberellin A 5 (GA 5 ) esters is presented, from which GA 5 may be prepared. The synthesis offers an inexpensive route of few steps to these compounds, starting from gibberellin A 3 (GA 3 ) esters in the presence of a metal hydride.
专利号:WO-2005103292-A1 优先权日:2004-04-27 标 题 :Method of monitoring gibberellin and abscisic acid synthesis during barley milling 发明人:OGAWA TOSHIYA 权利人:KIRIN BREWERY; OGAWA TOSHIYA 摘要:It is intended to provide a method of monitoring the synthesis of gibberellin and abscisic acid in germinating barley seeds during barley milling. Namely, a method of monitoring the synthesis of gibberellin and abscisic acid in germinating barley seeds during barley milling which comprises measuring the expression levels of gibberellin 3β-hydroxylase gene (HvGA3ox), gibberellin 20-oxidase gene (HvGA20ox) and 9-cis-epoxycarotenoid dioxygenase gene (HvNCED).
专利号:US-9113653-B2 优先权日:2011-08-19 标题:Methods of administering probiotic organisms that synthesize carotenoid compounds in situ to enhance human health and nutrition 发明人:MARANZ STEVEN J 权利人:MARANZ STEVEN J 摘要:A method is disclosed for increasing systemic carotenoid levels in humans through oral consumption of tablets, capsules, food or beverage products containing microbial organisms capable of synthesizing carotenoid compounds. Carotenoid synthesis may occur in situ by microbial organisms colonizing the gut, or in food or beverage products where carotenoids accumulate and are subsequently consumed dietarily. The microbial organisms may be either transgenic—thus expressing genes in the carotenoid synthesis pathway derived from other microbial organisms, or they may comprise species or strains selected for natural synthesis of carotenoids. The central objective of the invention is to provide an improvement in human health through a novel method for supplying and delivering carotenoid compounds.
专利号:WO-2013087821-A1 优先权日:2011-12-15 标题:Overproduction of jasmonates in transgenic plants 发明人:CHAMPION ANTONY 权利人:INST RECH DEVELOPPEMENT IRD 摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.
专利号:US-2003172398-A1 优先权日:1999-12-21 标 题 :Novel delta-12 desaturase and methods of using it for synthesis of polyunsaturated fatty acids 发明人:BROWSE JOHN A 摘要:Desaturase enzymes, and especially animal Δ 12 -desaturases, and the use of such enzymes to alter fatty acid saturation, especially fatty acid saturation in oilseeds, are disclosed. Also disclosed are nucleic acid sequences encoding animal Δ 12 -desaturase enzymes.
专利号:US-10266503-B1 优先权日:2016-05-24 标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins 发明人:WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN 权利人:UNIV ILLINOIS 摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.
参考文献:10.1016/j.bcp.2011.06.042 摘要:Li HH, Hao RL, Wu SS, Guo PC, Chen CJ, Pan LP, Ni H. Occurrence, function and potential medicinal applications of the phytohormone abscisic acid in animals and humans. Biochem Pharmacol. 2011 Oct 01;82(7):701–12. doi: 10.1016/j.bcp.2011.06.042.