CAS: 132679-61-9; (S)-2-((5-Fluoro-2,4-Dinitrophenyl)Amino)-3-Methylbutanamide
该化合物是化学化合物,具有特定结构特征,包括valinaide脊柱和二硝基氟联苯替代体,该化合物在医药化学中的潜在应用,特别是由于其独特的功能组群可能与生物目标相互作用,在药品开发方面的潜在应用值得注意;dinitro和氟化物替代体的存在,增强了其再活性并可能影响其药用植物特性;此外,L-valimide部分有助于其立体化学学,这对于生物活动至关重要;该化合物通常通过涉及矿物质和芳香化合物的有机反应合成,其特性可以使用NMR,质量光谱测量和染色法等各种分析技术加以研究;安全性和处理预防措施至关重要,因为有硝基体组群,可能十分危险.
- 英文名称(S)-2-((5-Fluoro-2,4-Dinitrophenyl)Amino)-3-Methylbutanamide
- 中文名称(S)-2-((5-氟-2,4-二硝基苯基)氨基)-3-甲基丁酰胺
- IUPAC名称(S)-2-((5-fluoro-2,4-dinitrophenyl)amino)-3-methylbutanamide
- 其它别名(S)-2-[(2,4-二硝基-5-氟苯基)氨基]-3-甲基丁酰胺; N(Alpha)-(2,4-Dinitro-5-Fluorophenyl)-L-Valinamide
- CAS编号132679-61-9
- MFCD编号:MFCD00155636
- EINECS号:635-049-2
- 分子式:C11H13FN4O5分子量:300.24
- 产品CID: 492318
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
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专利信息
专利号:EP-3599246-A1
优先权日:2018-07-25
标题 :Means and methods for synthesizing precursors of y-aminobutyric acid (gaba) analogs
发明人：POELARENDS GERRIT JAN; BIEWENGA LIEUWE; VAN DER MEER JAN-YTZEN; PODDAR HARSHWARDHAN; THANGAVELU SARAVANAN
权利人:UNIV GRONINGEN
摘要:The invention relates to the fields of drug development and biocatalysis, more specifically to a biocatalytic route for asymmetric synthesis of precursors of y-aminobutyric acid (GABA) analogs. Provided is an isolated mutant 4-oxalocrototonate tautomerase (4-OT) enzyme comprising the following mutations (i) leucine at position 8 substituted with a tyrosine (L8Y) or a phenylalanine (L8F); (ii) methionine at position 45 substituted with a tyrosine (M45Y); and (iii) phenylalanine at position 50 substituted with an alanine (F50A), wherein the positions are numbered according to the amino acid sequence of 4-OT ofPseudomonas putida.Also provided is a method for the synthesis of a precursor for the pharmaceutically relevant enantiomer of a GABA analog, comprising (i) providing a y-nitroaldehyde using the 4-OT mutant enzyme, followed by (ii) subjecting the thus obtained y-nitroaldehyde to an enzymatic oxidation reaction catalyzed by an aldehyde dehydrogenase (EC 1.2.1.3).
专利号:CN-119431184-A
优先权日:2024-10-31
标 题 :Synthesis method of (S) -3-aminobutyric acid
专利号:CN-118679166-A
优先权日:2021-12-30
标 题:Synthesis method of 1H-furo[3,2-b]imidazo[4,5-d]pyridine compound
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主要参考文献
[参考文献]: Eric J Dimise, Et Al. Structure Elucidation And Biosynthesis Of Fuscachelins, Peptide Siderophores From The Moderate Thermophile Thermobifida Fusca. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15311-6.合成参考文献
参考文献:10.1007/s44211-024-00530-w
摘要:Ishii C, Tojo Y, Iwasaki K, Fujii A, Akita T, Nagano M, Mita M, Ide T, Hamase K. Development of a two-dimensional LC-MS/MS system for the determination of proline and 4-hydroxyproline enantiomers in biological and food samples. Anal Sci. 2024 May;40(5):881–9. doi: 10.1007/s44211-024-00530-w.
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