CAS: 130674-54-3; (2R,3R)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-Hydroxybutanoic Acid

该化合物是一种受保护的氨酸,通常用于浸泡物合成,其特点是一个苯丙氧碳基(Fmoc)组,作为氨基功能的保护组,允许在浸泡物组装过程中有选择地作出反应.D-allo-Thr"的标识表明,它是异硫二甲胺的D-antiomer,一种非标准的氨酸,不同于其侧链条结构中的血清.这种化合物通常用于固相聚物合成,在基本条件下很容易去除,便于依次添加氨酸.Fmoc-D-allo-Thr-OHC的特征是其在标准实验室条件下的稳定性,有机溶剂溶性,以及与各种联动试剂的兼容性.其独特的结构和特性使得它对于开发与特定生物活动,特别是研究和制药应用中的浸泡物具有价值.

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120791-76-6 73724-48-8 253595-72-1

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上下游产品

D-allo-threonine α-(9-Fluorenylmethoxycarbonyl)-D-allothreonine t-butyl etherNα-(9-Fluorenylmethoxycarbonyl)-D-allothreonine t-butyl ether N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimideL-threonine N-methyl threonine N,N-dimethyl-threonine Nα-(9-fluorenylmethoxycarbonyl)-3-O-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-L-threonine

合成工艺路线路线简述

    📜D-别苏氨酸 反应生成芴甲氧羰基-L-苏氨酸
    参考文献:Solid-Phase Synthesis Of Viscosin,A Cyclic Depsipeptide With Antibacterial And Antiviral Properties
    标题:Solid-Phase Synthesis Of Viscosin,A Cyclic Depsipeptide With Antibacterial And Antiviral Properties
    摘要:
    Doi:10.1016/s0040-4039(00)95242-0

    海关参考信息

    专利信息


    专利号:US-8569452-B2
    优先权日:2011-02-17
    标题:Preparation of phalloidin and its derivatives
    发明人:LIU BAOSHENG; ZHANG JIANHENG
    权利人:LIU BAOSHENG; ZHANG JIANHENG; AMERICAN PEPTIDE COMPANY INC
    摘要:The present invention relates to novel phalloidin derivatives and their fluorescent dye conjugates. These new compounds may be used in studies of actin dynamics in living systems. The present invention also relates to methods for preparing such compounds. The synthesis routes combine solid-phase and solution phase peptide synthesis, and has great advantage for efficient preparation of a diverse library of the phalloidin derivatives, especially for the synthesis of phalloidin.

    专利号:US-2025011366-A1
    优先权日:2021-09-08
    标 题:Prodrugs of Antibiotic Teixobactin
    发明人:JONES CHELSEA R; NOWICK JAMES S
    权利人:UNIV CALIFORNIA
    摘要:Prodrugs of antibiotic teixobactin, methods of their synthesis, and methods of their use as antimicrobial treatments are described. The teixobactin prodrugs incorporate one or more O-acyl linkages. The O-acyl linkages can be utilized in substitution of amide peptide bonds between an amino acid containing an alcohol side chain and the immediately preceding amino acid.

    专利号:JP-2008506633-A
    优先权日:2004-04-22
    标题 :Convergent synthesis of kahalalide compounds

    专利号:US-11897970-B2
    优先权日:2017-03-09
    标 题 :Antibacterial products
    发明人:SINGH ISHWAR; TAYLOR EDWARD
    权利人:UNIV LIVERPOOL
    摘要:The invention provides novel antibacterial compounds of formulae IA, IB and IC as defined herein. Optionally, the antibacterial compounds can be bonded to a delivery agent that is capable of bonding to one or more structures on a bacterial cell membrane. The invention also provides the use of such compounds in treating or preventing bacterial infections, and processes for their synthesis.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献

    合成方法参考DOI号:10.1016/j.tet.2013.06.027
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